(31 nodes) Clathrin coat, and AP-3 adaptor complex network (Tuber melanosporum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	D5G4U6_TUBMM	ENTH domain-containing protein. (551 aa)
	D5G5N5_TUBMM	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (906 aa)
	D5G6B2_TUBMM	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (916 aa)
	D5G6G6_TUBMM	Uncharacterized protein. (208 aa)
	D5G6M8_TUBMM	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (240 aa)
	D5G7N4_TUBMM	Uncharacterized protein. (740 aa)
	D5G804_TUBMM	Uncharacterized protein. (236 aa)
	D5G8P9_TUBMM	Uncharacterized protein. (1062 aa)
	D5G9G2_TUBMM	Protein kinase domain-containing protein. (1023 aa)
	D5GAZ2_TUBMM	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1602 aa)
	D5GAZ8_TUBMM	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (725 aa)
	D5GEG3_TUBMM	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (436 aa)
	D5GEU8_TUBMM	Adaptin_N domain-containing protein. (798 aa)
	D5GF20_TUBMM	MHD domain-containing protein. (827 aa)
	D5GF31_TUBMM	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
	D5GGJ1_TUBMM	ENTH domain-containing protein. (524 aa)
	D5GGY0_TUBMM	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (148 aa)
	D5GH74_TUBMM	Uncharacterized protein. (1325 aa)
	D5GHW0_TUBMM	HeLo domain-containing protein. (552 aa)
	D5GIM1_TUBMM	ENTH domain-containing protein. (691 aa)
	D5GJI5_TUBMM	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (692 aa)
	D5GK10_TUBMM	Uncharacterized protein. (1380 aa)
	D5GL59_TUBMM	Rad60-SLD_2 domain-containing protein. (267 aa)
	D5GL68_TUBMM	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa)
	D5GLT8_TUBMM	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (198 aa)
	D5GLW2_TUBMM	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (430 aa)
	D5GM90_TUBMM	DUF1681 domain-containing protein. (237 aa)
	D5GN08_TUBMM	Rho-GAP domain-containing protein. (630 aa)
	D5GN74_TUBMM	AP-1 complex subunit gamma. (829 aa)
	D5GNB0_TUBMM	Uncharacterized protein. (408 aa)
	D5GPI7_TUBMM	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (528 aa)

Your Current Organism:

Tuber melanosporum

NCBI taxonomy Id: 656061
Other names: T. melanosporum Mel28, Tuber melanosporum Mel28

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D5G4U6_TUBMM	D5G5N5_TUBMM	D5G4U6	D5G5N5	ENTH domain-containing protein.	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	0.613
D5G4U6_TUBMM	D5G6M8_TUBMM	D5G4U6	D5G6M8	ENTH domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.846
D5G4U6_TUBMM	D5G804_TUBMM	D5G4U6	D5G804	ENTH domain-containing protein.	Uncharacterized protein.	0.816
D5G4U6_TUBMM	D5G8P9_TUBMM	D5G4U6	D5G8P9	ENTH domain-containing protein.	Uncharacterized protein.	0.706
D5G4U6_TUBMM	D5GAZ2_TUBMM	D5G4U6	D5GAZ2	ENTH domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.936
D5G4U6_TUBMM	D5GAZ8_TUBMM	D5G4U6	D5GAZ8	ENTH domain-containing protein.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.488
D5G4U6_TUBMM	D5GEG3_TUBMM	D5G4U6	D5GEG3	ENTH domain-containing protein.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.687
D5G4U6_TUBMM	D5GF31_TUBMM	D5G4U6	D5GF31	ENTH domain-containing protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.630
D5G4U6_TUBMM	D5GGJ1_TUBMM	D5G4U6	D5GGJ1	ENTH domain-containing protein.	ENTH domain-containing protein.	0.915
D5G4U6_TUBMM	D5GH74_TUBMM	D5G4U6	D5GH74	ENTH domain-containing protein.	Uncharacterized protein.	0.568
D5G4U6_TUBMM	D5GHW0_TUBMM	D5G4U6	D5GHW0	ENTH domain-containing protein.	HeLo domain-containing protein.	0.412
D5G4U6_TUBMM	D5GIM1_TUBMM	D5G4U6	D5GIM1	ENTH domain-containing protein.	ENTH domain-containing protein.	0.742
D5G4U6_TUBMM	D5GJI5_TUBMM	D5G4U6	D5GJI5	ENTH domain-containing protein.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.488
D5G4U6_TUBMM	D5GK10_TUBMM	D5G4U6	D5GK10	ENTH domain-containing protein.	Uncharacterized protein.	0.568
D5G4U6_TUBMM	D5GL59_TUBMM	D5G4U6	D5GL59	ENTH domain-containing protein.	Rad60-SLD_2 domain-containing protein.	0.488
D5G4U6_TUBMM	D5GM90_TUBMM	D5G4U6	D5GM90	ENTH domain-containing protein.	DUF1681 domain-containing protein.	0.539
D5G4U6_TUBMM	D5GN74_TUBMM	D5G4U6	D5GN74	ENTH domain-containing protein.	AP-1 complex subunit gamma.	0.613
D5G4U6_TUBMM	D5GNB0_TUBMM	D5G4U6	D5GNB0	ENTH domain-containing protein.	Uncharacterized protein.	0.612
D5G5N5_TUBMM	D5G4U6_TUBMM	D5G5N5	D5G4U6	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	ENTH domain-containing protein.	0.613
D5G5N5_TUBMM	D5G6B2_TUBMM	D5G5N5	D5G6B2	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.416