(52 nodes) RNA polymerase II, holoenzyme network (Tuber melanosporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D5GLV0_TUBMM	Uncharacterized protein. (241 aa)
	D5GLV5_TUBMM	Uncharacterized protein. (690 aa)
	D5GM25_TUBMM	WD_REPEATS_REGION domain-containing protein. (388 aa)
	D5GPG2_TUBMM	Plus3 domain-containing protein. (567 aa)
	D5GP56_TUBMM	TAFII28 domain-containing protein. (258 aa)
	D5GNP0_TUBMM	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (285 aa)
	D5GNN0_TUBMM	RPOL4c domain-containing protein. (146 aa)
	D5GNK6_TUBMM	Uncharacterized protein. (220 aa)
	D5GNK2_TUBMM	Uncharacterized protein. (76 aa)
	D5GNE3_TUBMM	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (762 aa)
	D5GNB6_TUBMM	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (378 aa)
	D5GN25_TUBMM	TFIID_20kDa domain-containing protein. (725 aa)
	D5GMM6_TUBMM	CDC73_C domain-containing protein. (415 aa)
	D5GME3_TUBMM	Helicase ATP-binding domain-containing protein. (748 aa)
	D5GM43_TUBMM	Uncharacterized protein. (616 aa)
	D5GM63_TUBMM	S1 motif domain-containing protein. (180 aa)
	D5GM47_TUBMM	Uncharacterized protein. (370 aa)
	D5GMC8_TUBMM	Uncharacterized protein. (73 aa)
	D5G445_TUBMM	Uncharacterized protein. (178 aa)
	D5G5X0_TUBMM	TAF domain-containing protein. (472 aa)
	D5G5X6_TUBMM	BTP domain-containing protein. (143 aa)
	D5G674_TUBMM	Uncharacterized protein; Belongs to the RNA polymerase beta chain family. (620 aa)
	D5G675_TUBMM	Uncharacterized protein. (436 aa)
	D5G763_TUBMM	RPOLD domain-containing protein. (340 aa)
	D5G7Q2_TUBMM	Uncharacterized protein. (174 aa)
	D5G7T0_TUBMM	Uncharacterized protein. (826 aa)
	D5G7W3_TUBMM	HTH TFE/IIEalpha-type domain-containing protein. (454 aa)
	D5G825_TUBMM	Uncharacterized protein. (436 aa)
	D5G8A7_TUBMM	RNA_pol_L_2 domain-containing protein. (119 aa)
	D5G915_TUBMM	Uncharacterized protein. (120 aa)
	D5G9K1_TUBMM	Uncharacterized protein. (156 aa)
	D5GB52_TUBMM	TAFII55_N domain-containing protein. (457 aa)
	D5GB65_TUBMM	DUF3591 domain-containing protein. (1084 aa)
	D5GBA6_TUBMM	CID domain-containing protein. (409 aa)
	D5GD47_TUBMM	Uncharacterized protein. (373 aa)
	D5GDH6_TUBMM	Uncharacterized protein. (337 aa)
	D5GDI7_TUBMM	Uncharacterized protein. (514 aa)
	D5GEA1_TUBMM	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (114 aa)
	D5GEJ8_TUBMM	Uncharacterized protein. (1181 aa)
	D5GEV5_TUBMM	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (115 aa)
	D5GIN2_TUBMM	RING-type domain-containing protein. (373 aa)
	D5GIQ1_TUBMM	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (203 aa)
	D5GJ86_TUBMM	Uncharacterized protein. (1269 aa)
	D5GJ94_TUBMM	Uncharacterized protein. (357 aa)
	D5GJJ3_TUBMM	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
	D5GJX7_TUBMM	Uncharacterized protein. (471 aa)
	D5GK28_TUBMM	TAF4 domain-containing protein. (443 aa)
	D5GK82_TUBMM	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (469 aa)
	D5GKH8_TUBMM	Uncharacterized protein. (422 aa)
	D5GKM4_TUBMM	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (460 aa)
	D5GKT6_TUBMM	Uncharacterized protein. (1025 aa)
	D5GL64_TUBMM	Uncharacterized protein. (390 aa)

Your Current Organism:

Tuber melanosporum

NCBI taxonomy Id: 656061
Other names: T. melanosporum Mel28, Tuber melanosporum Mel28

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D5G445_TUBMM	D5G5X0_TUBMM	D5G445	D5G5X0	Uncharacterized protein.	TAF domain-containing protein.	0.957
D5G445_TUBMM	D5G5X6_TUBMM	D5G445	D5G5X6	Uncharacterized protein.	BTP domain-containing protein.	0.549
D5G445_TUBMM	D5G674_TUBMM	D5G445	D5G674	Uncharacterized protein.	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	0.671
D5G445_TUBMM	D5G675_TUBMM	D5G445	D5G675	Uncharacterized protein.	Uncharacterized protein.	0.671
D5G445_TUBMM	D5G763_TUBMM	D5G445	D5G763	Uncharacterized protein.	RPOLD domain-containing protein.	0.780
D5G445_TUBMM	D5G7Q2_TUBMM	D5G445	D5G7Q2	Uncharacterized protein.	Uncharacterized protein.	0.757
D5G445_TUBMM	D5G7T0_TUBMM	D5G445	D5G7T0	Uncharacterized protein.	Uncharacterized protein.	0.737
D5G445_TUBMM	D5G7W3_TUBMM	D5G445	D5G7W3	Uncharacterized protein.	HTH TFE/IIEalpha-type domain-containing protein.	0.745
D5G445_TUBMM	D5G8A7_TUBMM	D5G445	D5G8A7	Uncharacterized protein.	RNA_pol_L_2 domain-containing protein.	0.704
D5G445_TUBMM	D5G9K1_TUBMM	D5G445	D5G9K1	Uncharacterized protein.	Uncharacterized protein.	0.745
D5G445_TUBMM	D5GB52_TUBMM	D5G445	D5GB52	Uncharacterized protein.	TAFII55_N domain-containing protein.	0.957
D5G445_TUBMM	D5GB65_TUBMM	D5G445	D5GB65	Uncharacterized protein.	DUF3591 domain-containing protein.	0.956
D5G445_TUBMM	D5GD47_TUBMM	D5G445	D5GD47	Uncharacterized protein.	Uncharacterized protein.	0.721
D5G445_TUBMM	D5GDH6_TUBMM	D5G445	D5GDH6	Uncharacterized protein.	Uncharacterized protein.	0.952
D5G445_TUBMM	D5GEA1_TUBMM	D5G445	D5GEA1	Uncharacterized protein.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.611
D5G445_TUBMM	D5GEV5_TUBMM	D5G445	D5GEV5	Uncharacterized protein.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.611
D5G445_TUBMM	D5GIN2_TUBMM	D5G445	D5GIN2	Uncharacterized protein.	RING-type domain-containing protein.	0.804
D5G445_TUBMM	D5GIQ1_TUBMM	D5G445	D5GIQ1	Uncharacterized protein.	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]	0.957
D5G445_TUBMM	D5GJ86_TUBMM	D5G445	D5GJ86	Uncharacterized protein.	Uncharacterized protein.	0.957
D5G445_TUBMM	D5GJ94_TUBMM	D5G445	D5GJ94	Uncharacterized protein.	Uncharacterized protein.	0.737