(167 nodes) Intracellular signal transduction network (Tuber melanosporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D5G3X7_TUBMM	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (661 aa)
	D5G423_TUBMM	Uncharacterized protein. (192 aa)
	D5G446_TUBMM	Uncharacterized protein. (297 aa)
	D5G452_TUBMM	Uncharacterized protein. (601 aa)
	D5G4A8_TUBMM	Uncharacterized protein. (1180 aa)
	D5G4M2_TUBMM	HABP4_PAI-RBP1 domain-containing protein. (332 aa)
	D5G4M6_TUBMM	Uncharacterized protein. (614 aa)
	D5G4P6_TUBMM	Response regulatory domain-containing protein. (512 aa)
	D5G4S1_TUBMM	Uncharacterized protein. (203 aa)
	D5G4S8_TUBMM	Uncharacterized protein. (1216 aa)
	D5G4S9_TUBMM	Uncharacterized protein; Belongs to the protein kinase superfamily. (430 aa)
	D5G4Z0_TUBMM	Uncharacterized protein; Belongs to the DOCK family. (1876 aa)
	D5G513_TUBMM	Uncharacterized protein. (519 aa)
	D5G553_TUBMM	Protein kinase domain-containing protein. (558 aa)
	D5G5B7_TUBMM	Protein kinase domain-containing protein. (535 aa)
	D5G5G2_TUBMM	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (769 aa)
	D5G5J5_TUBMM	Uncharacterized protein. (202 aa)
	D5G5K1_TUBMM	Uncharacterized protein. (382 aa)
	D5G5N0_TUBMM	Protein kinase domain-containing protein. (716 aa)
	D5G5S2_TUBMM	Uncharacterized protein. (1221 aa)
	D5G670_TUBMM	Protein kinase domain-containing protein. (525 aa)
	D5G695_TUBMM	Uncharacterized protein. (73 aa)
	D5G696_TUBMM	Uncharacterized protein. (336 aa)
	D5G6H0_TUBMM	Uncharacterized protein. (203 aa)
	D5G6J3_TUBMM	Uncharacterized protein. (1301 aa)
	D5G6J9_TUBMM	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (288 aa)
	D5G6Q1_TUBMM	Phosphoinositide phospholipase C. (1024 aa)
	D5G6U0_TUBMM	Uncharacterized protein. (1042 aa)
	D5G6V2_TUBMM	Protein kinase domain-containing protein. (554 aa)
	D5G6V5_TUBMM	Uncharacterized protein. (224 aa)
	D5G6X6_TUBMM	MAP kinase kinase kinase. (1356 aa)
	D5G757_TUBMM	Uncharacterized protein. (328 aa)
	D5G7A3_TUBMM	Uncharacterized protein. (450 aa)
	D5G7D9_TUBMM	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (125 aa)
	D5G7E5_TUBMM	Uncharacterized protein. (279 aa)
	D5G7M1_TUBMM	Uncharacterized protein; Belongs to the cytochrome P450 family. (388 aa)
	D5G7Z3_TUBMM	WD_REPEATS_REGION domain-containing protein. (1040 aa)
	D5G7Z4_TUBMM	Raptor_N domain-containing protein. (191 aa)
	D5G8D1_TUBMM	Uncharacterized protein. (499 aa)
	D5G8F7_TUBMM	Protein kinase domain-containing protein. (508 aa)
	D5G8L8_TUBMM	Uncharacterized protein. (272 aa)
	D5G8L9_TUBMM	Protein kinase domain-containing protein. (346 aa)
	D5G8P4_TUBMM	Uncharacterized protein. (196 aa)
	D5G8T8_TUBMM	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. (318 aa)
	D5G8U8_TUBMM	Phosphatidylinositol 3-kinase VPS34. (812 aa)
	D5G8Y7_TUBMM	Uncharacterized protein; Belongs to the BI1 family. (274 aa)
	D5G968_TUBMM	Protein kinase domain-containing protein. (996 aa)
	D5G9M5_TUBMM	BAH domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (939 aa)
	D5GA67_TUBMM	WAPL domain-containing protein. (990 aa)
	D5GA68_TUBMM	Uncharacterized protein. (186 aa)
	D5GA75_TUBMM	Uncharacterized protein. (175 aa)
	D5GA92_TUBMM	Uncharacterized protein. (60 aa)
	D5GAF3_TUBMM	Uncharacterized protein. (881 aa)
	D5GAJ2_TUBMM	HORMA domain-containing protein. (840 aa)
	D5GAK6_TUBMM	Phospholipase. (1428 aa)
	D5GAP7_TUBMM	Phosphoinositide phospholipase C. (607 aa)
	D5GAV5_TUBMM	Uncharacterized protein. (581 aa)
	D5GAX5_TUBMM	Uncharacterized protein. (97 aa)
	D5GBF4_TUBMM	Uncharacterized protein; Belongs to the protein kinase superfamily. (356 aa)
	D5GBI8_TUBMM	Uncharacterized protein. (335 aa)
	D5GBK8_TUBMM	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (438 aa)
	D5GC21_TUBMM	Phospholipase. (1062 aa)
	D5GC39_TUBMM	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (351 aa)
	D5GC60_TUBMM	Uncharacterized protein. (199 aa)
	D5GCE5_TUBMM	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (332 aa)
	D5GCP8_TUBMM	BRCT domain-containing protein. (1394 aa)
	D5GCS1_TUBMM	Uncharacterized protein. (1953 aa)
	D5GD19_TUBMM	Dsl1_C domain-containing protein. (848 aa)
	D5GD35_TUBMM	Response regulatory domain-containing protein. (601 aa)
	D5GD77_TUBMM	Checkpoint protein; Belongs to the HUS1 family. (287 aa)
	D5GD80_TUBMM	Uncharacterized protein. (633 aa)
	D5GDI4_TUBMM	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (427 aa)
	D5GDQ9_TUBMM	Uncharacterized protein. (239 aa)
	D5GDR0_TUBMM	Uncharacterized protein. (321 aa)
	D5GDX4_TUBMM	Protein kinase domain-containing protein. (1927 aa)
	D5GE02_TUBMM	Protein kinase domain-containing protein. (779 aa)
	D5GE30_TUBMM	ERCC4 domain-containing protein. (748 aa)
	D5GE65_TUBMM	Rab GDP dissociation inhibitor; Belongs to the Rab GDI family. (500 aa)
	D5GEE3_TUBMM	Uncharacterized protein. (1628 aa)
	D5GEI4_TUBMM	Uncharacterized protein. (1100 aa)
	D5GEL4_TUBMM	Uncharacterized protein. (345 aa)
	D5GEL5_TUBMM	Protein kinase domain-containing protein. (288 aa)
	D5GET4_TUBMM	Uncharacterized protein. (211 aa)
	D5GEU1_TUBMM	Uncharacterized protein. (144 aa)
	D5GEU2_TUBMM	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (939 aa)
	D5GEX8_TUBMM	Protein kinase domain-containing protein. (491 aa)
	D5GEY0_TUBMM	Protein kinase domain-containing protein. (411 aa)
	D5GEY7_TUBMM	Uncharacterized protein. (1966 aa)
	D5GF01_TUBMM	Uncharacterized protein. (1595 aa)
	D5GF02_TUBMM	Uncharacterized protein. (346 aa)
	D5GF78_TUBMM	Uncharacterized protein. (517 aa)
	D5GF92_TUBMM	Uncharacterized protein. (1100 aa)
	D5GFA0_TUBMM	Uncharacterized protein. (520 aa)
	D5GFB2_TUBMM	Uncharacterized protein. (2015 aa)
	D5GFE8_TUBMM	Uncharacterized protein. (961 aa)
	D5GFG4_TUBMM	Uncharacterized protein. (259 aa)
	D5GFG5_TUBMM	Uncharacterized protein. (105 aa)
	D5GFK8_TUBMM	Uncharacterized protein. (264 aa)
	D5GFL1_TUBMM	Non-specific serine/threonine protein kinase. (848 aa)
	D5GFL2_TUBMM	Uncharacterized protein. (356 aa)
	D5GFN7_TUBMM	Uncharacterized protein. (521 aa)
	D5GFN8_TUBMM	Uncharacterized protein. (269 aa)
	D5GFS1_TUBMM	Protein kinase domain-containing protein. (605 aa)
	D5GG06_TUBMM	Uncharacterized protein. (1066 aa)
	D5GG26_TUBMM	Non-specific serine/threonine protein kinase. (936 aa)
	D5GGD7_TUBMM	Uncharacterized protein. (973 aa)
	D5GGX7_TUBMM	Uncharacterized protein. (391 aa)
	D5GH25_TUBMM	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1684 aa)
	D5GH26_TUBMM	Uncharacterized protein. (327 aa)
	D5GH28_TUBMM	Uncharacterized protein. (611 aa)
	D5GH36_TUBMM	Uncharacterized protein. (866 aa)
	D5GH83_TUBMM	Adenylyl cyclase-associated protein; Belongs to the CAP family. (520 aa)
	D5GHA4_TUBMM	Uncharacterized protein. (202 aa)
	D5GHA6_TUBMM	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (377 aa)
	D5GHC4_TUBMM	Uncharacterized protein. (1063 aa)
	D5GHM3_TUBMM	WSC domain-containing protein. (213 aa)
	D5GI65_TUBMM	Protein kinase domain-containing protein. (772 aa)
	D5GID5_TUBMM	Serine/threonine-protein kinase. (631 aa)
	D5GIH8_TUBMM	Uncharacterized protein. (223 aa)
	D5GIT4_TUBMM	HPt domain-containing protein. (171 aa)
	D5GJ33_TUBMM	Rab-GAP TBC domain-containing protein. (380 aa)
	D5GJB2_TUBMM	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (260 aa)
	D5GJJ0_TUBMM	Uncharacterized protein. (347 aa)
	D5GJQ0_TUBMM	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2332 aa)
	D5GJT6_TUBMM	Uncharacterized protein. (515 aa)
	D5GKL9_TUBMM	Protein kinase domain-containing protein. (827 aa)
	D5GKW4_TUBMM	Uncharacterized protein. (1164 aa)
	D5GKY5_TUBMM	Uncharacterized protein. (572 aa)
	D5GKZ5_TUBMM	Uncharacterized protein. (1503 aa)
	D5GL83_TUBMM	Uncharacterized protein. (402 aa)
	D5GL84_TUBMM	DEP domain-containing protein. (1379 aa)
	D5GL95_TUBMM	Uncharacterized protein. (1260 aa)
	D5GLF6_TUBMM	Uncharacterized protein. (439 aa)
	D5GLG6_TUBMM	Uncharacterized protein. (300 aa)
	D5GLK2_TUBMM	Protein kinase domain-containing protein. (715 aa)
	D5GLL6_TUBMM	Uncharacterized protein. (515 aa)
	D5GLM5_TUBMM	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (867 aa)
	D5GLM8_TUBMM	Uncharacterized protein; Belongs to the calmodulin family. (98 aa)
	D5GM08_TUBMM	Protein kinase domain-containing protein. (1027 aa)
	D5GM16_TUBMM	Uncharacterized protein. (659 aa)
	D5GM69_TUBMM	Uncharacterized protein. (874 aa)
	D5GMN9_TUBMM	Uncharacterized protein. (508 aa)
	D5GMT2_TUBMM	Uncharacterized protein. (221 aa)
	D5GMT3_TUBMM	ERCC4 domain-containing protein. (317 aa)
	D5GMY2_TUBMM	AAA domain-containing protein; Belongs to the AAA ATPase family. (286 aa)
	D5GN08_TUBMM	Rho-GAP domain-containing protein. (630 aa)
	D5GN68_TUBMM	TYR_PHOSPHATASE_2 domain-containing protein. (618 aa)
	D5GND7_TUBMM	Phosphatase tensin-type domain-containing protein. (369 aa)
	D5GNG7_TUBMM	Spc7 domain-containing protein. (1670 aa)
	D5GNM8_TUBMM	Uncharacterized protein. (1775 aa)
	D5GNP2_TUBMM	Uncharacterized protein. (1044 aa)
	D5GNQ1_TUBMM	Uncharacterized protein. (570 aa)
	D5GP49_TUBMM	IPPc domain-containing protein. (1263 aa)
	D5GPB3_TUBMM	WD_REPEATS_REGION domain-containing protein. (307 aa)
	D5GPD1_TUBMM	Serine/threonine-protein phosphatase. (569 aa)
	D5GPI5_TUBMM	HORMA domain-containing protein. (216 aa)
	D5GPI8_TUBMM	Protein kinase domain-containing protein. (573 aa)
	D5GPI9_TUBMM	MRC1 domain-containing protein. (1224 aa)
	D5GPN2_TUBMM	Uncharacterized protein. (621 aa)
	D5GPN3_TUBMM	Uncharacterized protein. (852 aa)
	D5GPP1_TUBMM	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1904 aa)
	D5GPP7_TUBMM	Uncharacterized protein. (283 aa)
	D5GPS4_TUBMM	Ras-GAP domain-containing protein. (1224 aa)
	D5GPW2_TUBMM	Protein kinase domain-containing protein. (613 aa)
	D5GQ28_TUBMM	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (435 aa)
	D5GQ29_TUBMM	Fungal_KA1 domain-containing protein. (387 aa)
	D5GQ72_TUBMM	Uncharacterized protein. (623 aa)

Your Current Organism:

Tuber melanosporum

NCBI taxonomy Id: 656061
Other names: T. melanosporum Mel28, Tuber melanosporum Mel28

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D5G3X7_TUBMM	D5G446_TUBMM	D5G3X7	D5G446	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.427
D5G3X7_TUBMM	D5G4M6_TUBMM	D5G3X7	D5G4M6	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.999
D5G3X7_TUBMM	D5GA75_TUBMM	D5G3X7	D5GA75	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.416
D5G3X7_TUBMM	D5GBI8_TUBMM	D5G3X7	D5GBI8	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.467
D5G3X7_TUBMM	D5GF92_TUBMM	D5G3X7	D5GF92	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.932
D5G3X7_TUBMM	D5GFE8_TUBMM	D5G3X7	D5GFE8	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.427
D5G3X7_TUBMM	D5GID5_TUBMM	D5G3X7	D5GID5	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein kinase.	0.664
D5G3X7_TUBMM	D5GIH8_TUBMM	D5G3X7	D5GIH8	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.427
D5G3X7_TUBMM	D5GPD1_TUBMM	D5G3X7	D5GPD1	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase.	0.784
D5G3X7_TUBMM	D5GPI5_TUBMM	D5G3X7	D5GPI5	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	HORMA domain-containing protein.	0.560
D5G423_TUBMM	D5G4A8_TUBMM	D5G423	D5G4A8	Uncharacterized protein.	Uncharacterized protein.	0.477
D5G423_TUBMM	D5G4S1_TUBMM	D5G423	D5G4S1	Uncharacterized protein.	Uncharacterized protein.	0.409
D5G423_TUBMM	D5G4S8_TUBMM	D5G423	D5G4S8	Uncharacterized protein.	Uncharacterized protein.	0.988
D5G423_TUBMM	D5G4Z0_TUBMM	D5G423	D5G4Z0	Uncharacterized protein.	Uncharacterized protein; Belongs to the DOCK family.	0.697
D5G423_TUBMM	D5G5J5_TUBMM	D5G423	D5G5J5	Uncharacterized protein.	Uncharacterized protein.	0.923
D5G423_TUBMM	D5G5K1_TUBMM	D5G423	D5G5K1	Uncharacterized protein.	Uncharacterized protein.	0.411
D5G423_TUBMM	D5G6U0_TUBMM	D5G423	D5G6U0	Uncharacterized protein.	Uncharacterized protein.	0.963
D5G423_TUBMM	D5G8P4_TUBMM	D5G423	D5G8P4	Uncharacterized protein.	Uncharacterized protein.	0.619
D5G423_TUBMM	D5GBK8_TUBMM	D5G423	D5GBK8	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.674
D5G423_TUBMM	D5GC39_TUBMM	D5G423	D5GC39	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.400