(11 nodes) Regulation of transcription initiation from RNA polymerase II promoter network (Tuber melanosporum)

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Your Input:
	D5GMY8_TUBMM	AAA domain-containing protein; Belongs to the AAA ATPase family. (455 aa)
	D5G413_TUBMM	AAA domain-containing protein; Belongs to the AAA ATPase family. (386 aa)
	D5G4M1_TUBMM	AAA domain-containing protein; Belongs to the AAA ATPase family. (389 aa)
	D5G9G1_TUBMM	Uncharacterized protein. (1645 aa)
	D5GD20_TUBMM	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1419 aa)
	D5GDH3_TUBMM	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (218 aa)
	D5GEA1_TUBMM	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (114 aa)
	D5GEV5_TUBMM	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (115 aa)
	D5GI20_TUBMM	AAA domain-containing protein; Belongs to the AAA ATPase family. (413 aa)
	D5GIF9_TUBMM	CBFD_NFYB_HMF domain-containing protein. (144 aa)
	D5GN86_TUBMM	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (570 aa)

Your Current Organism:

Tuber melanosporum

NCBI taxonomy Id: 656061
Other names: T. melanosporum Mel28, Tuber melanosporum Mel28

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D5G413_TUBMM	D5G4M1_TUBMM	D5G413	D5G4M1	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
D5G413_TUBMM	D5GI20_TUBMM	D5G413	D5GI20	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
D5G413_TUBMM	D5GMY8_TUBMM	D5G413	D5GMY8	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
D5G4M1_TUBMM	D5G413_TUBMM	D5G4M1	D5G413	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
D5G4M1_TUBMM	D5GI20_TUBMM	D5G4M1	D5GI20	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
D5G4M1_TUBMM	D5GMY8_TUBMM	D5G4M1	D5GMY8	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
D5G9G1_TUBMM	D5GIF9_TUBMM	D5G9G1	D5GIF9	Uncharacterized protein.	CBFD_NFYB_HMF domain-containing protein.	0.874
D5GD20_TUBMM	D5GDH3_TUBMM	D5GD20	D5GDH3	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.549
D5GD20_TUBMM	D5GN86_TUBMM	D5GD20	D5GN86	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.982
D5GDH3_TUBMM	D5GD20_TUBMM	D5GDH3	D5GD20	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.549
D5GDH3_TUBMM	D5GEA1_TUBMM	D5GDH3	D5GEA1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.452
D5GDH3_TUBMM	D5GEV5_TUBMM	D5GDH3	D5GEV5	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.452
D5GDH3_TUBMM	D5GN86_TUBMM	D5GDH3	D5GN86	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.619
D5GEA1_TUBMM	D5GDH3_TUBMM	D5GEA1	D5GDH3	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.452
D5GEA1_TUBMM	D5GEV5_TUBMM	D5GEA1	D5GEV5	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.901
D5GEV5_TUBMM	D5GDH3_TUBMM	D5GEV5	D5GDH3	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.452
D5GEV5_TUBMM	D5GEA1_TUBMM	D5GEV5	D5GEA1	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.901
D5GI20_TUBMM	D5G413_TUBMM	D5GI20	D5G413	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
D5GI20_TUBMM	D5G4M1_TUBMM	D5GI20	D5G4M1	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
D5GI20_TUBMM	D5GMY8_TUBMM	D5GI20	D5GMY8	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999