(26 nodes) Valine, leucine and isoleucine degradation network (Tuber melanosporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D5G4S2_TUBMM	Uncharacterized protein. (566 aa)
	D5G4S3_TUBMM	Uncharacterized protein. (433 aa)
	D5G4X0_TUBMM	Transket_pyr domain-containing protein. (394 aa)
	D5G5H0_TUBMM	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (496 aa)
	D5G5J7_TUBMM	Uncharacterized protein. (296 aa)
	D5G6G8_TUBMM	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (288 aa)
	D5G9E0_TUBMM	Peripheral subunit-binding (PSBD) domain-containing protein. (510 aa)
	D5G9Y3_TUBMM	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	D5GAR7_TUBMM	Uncharacterized protein. (235 aa)
	D5GD45_TUBMM	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
	D5GD97_TUBMM	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (416 aa)
	D5GDL1_TUBMM	Pyruvate carboxyltransferase domain-containing protein. (331 aa)
	D5GDV4_TUBMM	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (503 aa)
	D5GEM4_TUBMM	Uncharacterized protein. (334 aa)
	D5GEZ1_TUBMM	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
	D5GFL7_TUBMM	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (450 aa)
	D5GFY7_TUBMM	Uncharacterized protein. (420 aa)
	D5GGM7_TUBMM	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	D5GGN7_TUBMM	Dihydrolipoyl dehydrogenase. (506 aa)
	D5GGY6_TUBMM	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (474 aa)
	D5GHM7_TUBMM	Uncharacterized protein. (654 aa)
	D5GI55_TUBMM	Acyl-CoA_dh_1 domain-containing protein. (197 aa)
	D5GIY7_TUBMM	Aldedh domain-containing protein. (541 aa)
	D5GKN6_TUBMM	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (479 aa)
	D5GN05_TUBMM	Uncharacterized protein. (367 aa)
	D5GNX9_TUBMM	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (419 aa)

Your Current Organism:

Tuber melanosporum

NCBI taxonomy Id: 656061
Other names: T. melanosporum Mel28, Tuber melanosporum Mel28

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D5G4S2_TUBMM	D5G4S3_TUBMM	D5G4S2	D5G4S3	Uncharacterized protein.	Uncharacterized protein.	0.988
D5G4S2_TUBMM	D5G4X0_TUBMM	D5G4S2	D5G4X0	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.832
D5G4S2_TUBMM	D5G6G8_TUBMM	D5G4S2	D5G6G8	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.963
D5G4S2_TUBMM	D5G9E0_TUBMM	D5G4S2	D5G9E0	Uncharacterized protein.	Peripheral subunit-binding (PSBD) domain-containing protein.	0.807
D5G4S2_TUBMM	D5G9Y3_TUBMM	D5G4S2	D5G9Y3	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.581
D5G4S2_TUBMM	D5GD97_TUBMM	D5G4S2	D5GD97	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.581
D5G4S2_TUBMM	D5GDL1_TUBMM	D5G4S2	D5GDL1	Uncharacterized protein.	Pyruvate carboxyltransferase domain-containing protein.	0.876
D5G4S2_TUBMM	D5GDV4_TUBMM	D5G4S2	D5GDV4	Uncharacterized protein.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.528
D5G4S2_TUBMM	D5GEM4_TUBMM	D5G4S2	D5GEM4	Uncharacterized protein.	Uncharacterized protein.	0.572
D5G4S2_TUBMM	D5GEZ1_TUBMM	D5G4S2	D5GEZ1	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.581
D5G4S2_TUBMM	D5GFL7_TUBMM	D5G4S2	D5GFL7	Uncharacterized protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.903
D5G4S2_TUBMM	D5GFY7_TUBMM	D5G4S2	D5GFY7	Uncharacterized protein.	Uncharacterized protein.	0.900
D5G4S2_TUBMM	D5GGM7_TUBMM	D5G4S2	D5GGM7	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.979
D5G4S2_TUBMM	D5GGY6_TUBMM	D5G4S2	D5GGY6	Uncharacterized protein.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.637
D5G4S2_TUBMM	D5GHM7_TUBMM	D5G4S2	D5GHM7	Uncharacterized protein.	Uncharacterized protein.	0.417
D5G4S2_TUBMM	D5GI55_TUBMM	D5G4S2	D5GI55	Uncharacterized protein.	Acyl-CoA_dh_1 domain-containing protein.	0.955
D5G4S2_TUBMM	D5GIY7_TUBMM	D5G4S2	D5GIY7	Uncharacterized protein.	Aldedh domain-containing protein.	0.419
D5G4S2_TUBMM	D5GNX9_TUBMM	D5G4S2	D5GNX9	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.581
D5G4S3_TUBMM	D5G4S2_TUBMM	D5G4S3	D5G4S2	Uncharacterized protein.	Uncharacterized protein.	0.988
D5G4S3_TUBMM	D5G4X0_TUBMM	D5G4S3	D5G4X0	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.693