(19 nodes) Lysine degradation network (Tuber melanosporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D5G543_TUBMM	Uncharacterized protein. (426 aa)
	D5G564_TUBMM	Lipoyl-binding domain-containing protein. (441 aa)
	D5G5H0_TUBMM	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (496 aa)
	D5G5S4_TUBMM	Uncharacterized protein. (459 aa)
	D5G6G8_TUBMM	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (288 aa)
	D5G7U3_TUBMM	Uncharacterized protein. (901 aa)
	D5G9C4_TUBMM	SET domain-containing protein. (355 aa)
	D5G9Y3_TUBMM	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	D5GBF0_TUBMM	Uncharacterized protein; Belongs to the aldehyde dehydrogenase family. (449 aa)
	D5GC56_TUBMM	DAO domain-containing protein. (402 aa)
	D5GCD9_TUBMM	Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Belongs to the AlaDH/PNT family. (369 aa)
	D5GD57_TUBMM	Uncharacterized protein. (456 aa)
	D5GEI8_TUBMM	Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (892 aa)
	D5GEZ1_TUBMM	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
	D5GFN9_TUBMM	SET domain-containing protein. (593 aa)
	D5GGN7_TUBMM	Dihydrolipoyl dehydrogenase. (506 aa)
	D5GHA6_TUBMM	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (377 aa)
	D5GKI6_TUBMM	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1200 aa)
	D5GM40_TUBMM	Uncharacterized protein. (489 aa)

Your Current Organism:

Tuber melanosporum

NCBI taxonomy Id: 656061
Other names: T. melanosporum Mel28, Tuber melanosporum Mel28

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D5G543_TUBMM	D5G564_TUBMM	D5G543	D5G564	Uncharacterized protein.	Lipoyl-binding domain-containing protein.	0.940
D5G543_TUBMM	D5G6G8_TUBMM	D5G543	D5G6G8	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.965
D5G543_TUBMM	D5G9Y3_TUBMM	D5G543	D5G9Y3	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.630
D5G543_TUBMM	D5GEZ1_TUBMM	D5G543	D5GEZ1	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.630
D5G543_TUBMM	D5GGN7_TUBMM	D5G543	D5GGN7	Uncharacterized protein.	Dihydrolipoyl dehydrogenase.	0.948
D5G564_TUBMM	D5G543_TUBMM	D5G564	D5G543	Lipoyl-binding domain-containing protein.	Uncharacterized protein.	0.940
D5G564_TUBMM	D5G9Y3_TUBMM	D5G564	D5G9Y3	Lipoyl-binding domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.822
D5G564_TUBMM	D5GEZ1_TUBMM	D5G564	D5GEZ1	Lipoyl-binding domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.822
D5G564_TUBMM	D5GGN7_TUBMM	D5G564	D5GGN7	Lipoyl-binding domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.999
D5G6G8_TUBMM	D5G543_TUBMM	D5G6G8	D5G543	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.965
D5G6G8_TUBMM	D5G9Y3_TUBMM	D5G6G8	D5G9Y3	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.786
D5G6G8_TUBMM	D5GEZ1_TUBMM	D5G6G8	D5GEZ1	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.767
D5G7U3_TUBMM	D5G9C4_TUBMM	D5G7U3	D5G9C4	Uncharacterized protein.	SET domain-containing protein.	0.911
D5G7U3_TUBMM	D5GEI8_TUBMM	D5G7U3	D5GEI8	Uncharacterized protein.	Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	0.975
D5G7U3_TUBMM	D5GFN9_TUBMM	D5G7U3	D5GFN9	Uncharacterized protein.	SET domain-containing protein.	0.946
D5G7U3_TUBMM	D5GHA6_TUBMM	D5G7U3	D5GHA6	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	0.941
D5G7U3_TUBMM	D5GKI6_TUBMM	D5G7U3	D5GKI6	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.	0.928
D5G7U3_TUBMM	D5GM40_TUBMM	D5G7U3	D5GM40	Uncharacterized protein.	Uncharacterized protein.	0.921
D5G9C4_TUBMM	D5G7U3_TUBMM	D5G9C4	D5G7U3	SET domain-containing protein.	Uncharacterized protein.	0.911
D5G9C4_TUBMM	D5GEI8_TUBMM	D5G9C4	D5GEI8	SET domain-containing protein.	Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	0.918