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rpsB rpsB LDG_8922 LDG_8922 clpS clpS LDG_5341 LDG_5341 priA priA LDG_5385 LDG_5385 LDG_5441 LDG_5441 gyrB gyrB rpmH rpmH LDG_5513 LDG_5513 LDG_5689 LDG_5689 LDG_5857 LDG_5857 LDG_5972 LDG_5972 LDG_5992 LDG_5992 LDG_5994 LDG_5994 LDG_6033 LDG_6033 LDG_6105 LDG_6105 parC parC LDG_6438 LDG_6438 LDG_6509 LDG_6509 parE parE LDG_6612 LDG_6612 rpsU rpsU LDG_6687 LDG_6687 topA topA LDG_6840 LDG_6840 LDG_6841 LDG_6841 gyrA gyrA LDG_6895 LDG_6895 LDG_7134 LDG_7134 rpmE rpmE LDG_7408 LDG_7408 LDG_7452 LDG_7452 LDG_7504 LDG_7504 LDG_7660 LDG_7660 rpmF rpmF LDG_7784 LDG_7784 gvpA gvpA LDG_7832 LDG_7832 LDG_7833 LDG_7833 rpsF rpsF rpsR rpsR rplI rplI LDG_8146 LDG_8146 LDG_8227 LDG_8227 rpsI rpsI rplM rplM rplT rplT rpmI rpmI LDG_8289 LDG_8289 LDG_8292 LDG_8292 LDG_8331 LDG_8331 rplK rplK rplA rplA rplJ rplJ rplL rplL LDG_8350 LDG_8350 rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplE rplE rpsN rpsN rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rplO rplO rpsM rpsM rpsK rpsK rpsD rpsD rplQ rplQ rplS rplS LDG_8444 LDG_8444 rpsP rpsP smc smc LDG_8576 LDG_8576 rpmG rpmG LDG_8579 LDG_8579 rplY rplY rplU rplU rpmA rpmA LDG_8995 LDG_8995 rpsT rpsT LDG_8647 LDG_8647 LDG_8732 LDG_8732 LDG_8768 LDG_8768 rpsO rpsO recR recR LDG_8819 LDG_8819 LDG_8896 LDG_8896
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpsB30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (248 aa)
LDG_8922Hypothetical protein; Belongs to the transcriptional regulatory Fis family. (93 aa)
clpSHypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (107 aa)
LDG_5341Hypothetical protein; Belongs to the UPF0145 family. (404 aa)
priAPrimosomal protein N (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (720 aa)
LDG_5385Hypothetical protein; Belongs to the ParB family. (289 aa)
LDG_5441Hypothetical protein; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (105 aa)
gyrBDNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] (805 aa)
rpmH50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
LDG_5513Hypothetical protein. (509 aa)
LDG_5689Hypothetical protein. (302 aa)
LDG_5857Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (460 aa)
LDG_5972Hypothetical protein. (251 aa)
LDG_5992Hypothetical protein. (252 aa)
LDG_5994Hypothetical protein. (528 aa)
LDG_6033Hypothetical protein. (725 aa)
LDG_6105Hypothetical protein. (432 aa)
parCHypothetical protein; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (756 aa)
LDG_6438Hypothetical protein. (607 aa)
LDG_6509Hypothetical protein; Involved in DNA repair and RecF pathway recombination. (204 aa)
parEHypothetical protein; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (627 aa)
LDG_6612DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (503 aa)
rpsU30S ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (75 aa)
LDG_6687Hypothetical protein. (510 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (761 aa)
LDG_6840Ribosomal protein S1. (488 aa)
LDG_6841Hypothetical protein. (44 aa)
gyrADNA gyrase, subunit A, type II topoisomerase; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP- [...] (871 aa)
LDG_6895Hypothetical protein. (251 aa)
LDG_7134DNA primase traC. (728 aa)
rpmEHypothetical protein; Binds the 23S rRNA. (77 aa)
LDG_7408Hypothetical protein; Belongs to the ParB family. (263 aa)
LDG_7452Hypothetical protein. (668 aa)
LDG_7504Hypothetical protein; Belongs to the SOS response-associated peptidase family. (230 aa)
LDG_7660Hypothetical protein. (394 aa)
rpmFHypothetical protein; Belongs to the bacterial ribosomal protein bL32 family. (64 aa)
LDG_7784Hypothetical protein; Belongs to the transcriptional regulatory Fis family. (99 aa)
gvpAHypothetical protein; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure. (72 aa)
LDG_7832Hypothetical protein. (98 aa)
LDG_7833Hypothetical protein; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. (106 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (112 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa)
rplI50S ribosomal protein L9; Binds to the 23S rRNA. (149 aa)
LDG_8146Hypothetical protein; Belongs to the transcriptional regulatory Fis family. (93 aa)
LDG_8227Hypothetical protein. (131 aa)
rpsI30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (143 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (144 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
rpmIHypothetical protein; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
LDG_8289Chromosome partitioning protein; Belongs to the ParB family. (299 aa)
LDG_8292Hypothetical protein; Belongs to the ParB family. (319 aa)
LDG_8331Hypothetical protein. (666 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (144 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (231 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (174 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (124 aa)
LDG_8350Hypothetical protein. (40 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (174 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (105 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (216 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (201 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (98 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (275 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplV50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (111 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (137 aa)
rpmC50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (64 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (83 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (121 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (183 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (100 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (131 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (119 aa)
rpsEHypothetical protein; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (168 aa)
rpmDHypothetical protein. (61 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
rpsMHypothetical protein; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (118 aa)
rpsKHypothetical protein; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (132 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa)
rplQ50S ribosomal protein L17. (126 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (121 aa)
LDG_8444Hypothetical protein. (115 aa)
rpsP30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (85 aa)
smcChromosome segregation SMC protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1164 aa)
LDG_8576Sigma-54 modulation protein. (95 aa)
rpmG50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
LDG_857950S ribosomal protein L28. (66 aa)
rplY50S ribosomal protein L25/general stress protein Ctc; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (220 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpmA50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (92 aa)
LDG_8995Hypothetical protein. (45 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa)
LDG_8647DNA polymerase III, chi subunit. (144 aa)
LDG_8732DNA repair protein recN; May be involved in recombinational repair of damaged DNA. (554 aa)
LDG_8768Hypothetical protein; Belongs to the DnaA family. HdA subfamily. (226 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (91 aa)
recRRecombinational DNA repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (197 aa)
LDG_8819Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (111 aa)
LDG_8896Recombination factor protein RarA. (432 aa)
Your Current Organism:
Legionella drancourtii
NCBI taxonomy Id: 658187
Other names: L. drancourtii LLAP12, Legionella drancourtii LLAP12, Legionella drancourtii str. LLAP12, Legionella drancourtii strain LLAP12
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