(26 nodes) Endosome transport via multivesicular body sorting pathway network (Pseudogymnoascus destructans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GMDG_05722	Uncharacterized protein. (228 aa)
	GMDG_08475	Charged multivesicular body protein 2A. (226 aa)
	GMDG_02128	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (253 aa)
	GMDG_00410	Uncharacterized protein. (872 aa)
	GMDG_00486	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (234 aa)
	GMDG_03311	Uncharacterized protein. (297 aa)
	GMDG_03445	Uncharacterized protein. (129 aa)
	GMDG_00512	Charged multivesicular body protein 5. (212 aa)
	GMDG_00437	Uncharacterized protein. (183 aa)
	GMDG_03875	Uncharacterized protein. (152 aa)
	GMDG_03751	Uncharacterized protein. (476 aa)
	GMDG_03775	Uncharacterized protein. (239 aa)
	GMDG_03843	B30.2/SPRY domain-containing protein. (533 aa)
	GMDG_04155	Charged multivesicular body protein 4. (226 aa)
	GMDG_07351	GLUE N-terminal domain-containing protein. (633 aa)
	GMDG_06608	Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (295 aa)
	GMDG_06743	Uncharacterized protein. (436 aa)
	GMDG_01432	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (843 aa)
	GMDG_01328	Vacuolar protein-sorting-associated protein 4; Belongs to the AAA ATPase family. (433 aa)
	GMDG_01004	Uncharacterized protein. (172 aa)
	GMDG_05721	Uncharacterized protein. (626 aa)
	GMDG_05580	Uncharacterized protein. (201 aa)
	GMDG_00914	Uncharacterized protein. (172 aa)
	GMDG_07848	Uncharacterized protein. (523 aa)
	GMDG_07914	E3 ubiquitin-protein ligase. (816 aa)
	GMDG_07639	MPN domain-containing protein. (516 aa)

Your Current Organism:

Pseudogymnoascus destructans

NCBI taxonomy Id: 658429
Other names: Geomyces destructans 20631-21, P. destructans 20631-21, Pseudogymnoascus destructans 20631-21

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GMDG_00410	GMDG_03843	L8G547	L8G9E9	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.457
GMDG_00410	GMDG_07914	L8G547	L8G0S8	Uncharacterized protein.	E3 ubiquitin-protein ligase.	0.679
GMDG_00437	GMDG_00486	L8G743	L8G5L2	Uncharacterized protein.	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.989
GMDG_00437	GMDG_00512	L8G743	L8G702	Uncharacterized protein.	Charged multivesicular body protein 5.	0.518
GMDG_00437	GMDG_00914	L8G743	L8FMP2	Uncharacterized protein.	Uncharacterized protein.	0.587
GMDG_00437	GMDG_01328	L8G743	L8FTA6	Uncharacterized protein.	Vacuolar protein-sorting-associated protein 4; Belongs to the AAA ATPase family.	0.558
GMDG_00437	GMDG_02128	L8G743	L8G346	Uncharacterized protein.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.999
GMDG_00437	GMDG_03311	L8G743	L8G5W4	Uncharacterized protein.	Uncharacterized protein.	0.477
GMDG_00437	GMDG_03751	L8G743	L8G964	Uncharacterized protein.	Uncharacterized protein.	0.836
GMDG_00437	GMDG_04155	L8G743	L8G9Y4	Uncharacterized protein.	Charged multivesicular body protein 4.	0.928
GMDG_00437	GMDG_05580	L8G743	L8FP09	Uncharacterized protein.	Uncharacterized protein.	0.997
GMDG_00437	GMDG_05721	L8G743	L8FPF3	Uncharacterized protein.	Uncharacterized protein.	0.754
GMDG_00437	GMDG_05722	L8G743	L8FQN3	Uncharacterized protein.	Uncharacterized protein.	0.754
GMDG_00437	GMDG_06743	L8G743	L8FV08	Uncharacterized protein.	Uncharacterized protein.	0.451
GMDG_00437	GMDG_07351	L8G743	L8FXZ6	Uncharacterized protein.	GLUE N-terminal domain-containing protein.	0.999
GMDG_00437	GMDG_08475	L8G743	L8G2T3	Uncharacterized protein.	Charged multivesicular body protein 2A.	0.909
GMDG_00486	GMDG_00437	L8G5L2	L8G743	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	Uncharacterized protein.	0.989
GMDG_00486	GMDG_00512	L8G5L2	L8G702	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	Charged multivesicular body protein 5.	0.587
GMDG_00486	GMDG_00914	L8G5L2	L8FMP2	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	Uncharacterized protein.	0.603
GMDG_00486	GMDG_01328	L8G5L2	L8FTA6	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	Vacuolar protein-sorting-associated protein 4; Belongs to the AAA ATPase family.	0.695