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GMDG_07557 GMDG_07557 GMDG_08507 GMDG_08507 COQ3 COQ3 GMDG_02754 GMDG_02754 GMDG_08590 GMDG_08590 GMDG_02917 GMDG_02917 GMDG_08499 GMDG_08499 GMDG_02701 GMDG_02701 GMDG_02977 GMDG_02977 GMDG_02889 GMDG_02889 GMDG_02904 GMDG_02904 GMDG_08200 GMDG_08200 GMDG_02666 GMDG_02666 COQ7 COQ7 GMDG_02776 GMDG_02776 GMDG_03587 GMDG_03587 GMDG_02728 GMDG_02728 GMDG_00399 GMDG_00399 GMDG_00919 GMDG_00919 GMDG_08799 GMDG_08799 GMDG_08766 GMDG_08766 GMDG_05173 GMDG_05173 GMDG_05443 GMDG_05443 GMDG_01036 GMDG_01036 GMDG_00008 GMDG_00008 GMDG_00006 GMDG_00006 GMDG_00920 GMDG_00920 GMDG_05156 GMDG_05156 GMDG_04625 GMDG_04625 GMDG_04622 GMDG_04622 GMDG_00688 GMDG_00688 hxB hxB GMDG_04958 GMDG_04958 GMDG_04715 GMDG_04715 GMDG_04197 GMDG_04197 GMDG_04207 GMDG_04207 GMDG_04836 GMDG_04836 GMDG_04987 GMDG_04987 GMDG_04986 GMDG_04986 GMDG_04957 GMDG_04957 GMDG_07688 GMDG_07688 GMDG_07042 GMDG_07042 GMDG_07723 GMDG_07723 GMDG_08497 GMDG_08497 GMDG_01876 GMDG_01876 GMDG_07636 GMDG_07636 GMDG_07697 GMDG_07697 GMDG_01926 GMDG_01926 GMDG_01925 GMDG_01925 GMDG_02084 GMDG_02084 GMDG_01987 GMDG_01987 GMDG_02002 GMDG_02002 GMDG_02049 GMDG_02049 GMDG_07868 GMDG_07868 GMDG_02062 GMDG_02062 GMDG_05199 GMDG_05199 GMDG_08201 GMDG_08201 GMDG_08331 GMDG_08331 GMDG_08356 GMDG_08356 GMDG_08130 GMDG_08130 GMDG_08279 GMDG_08279 GMDG_02295 GMDG_02295 GMDG_02366 GMDG_02366 GMDG_02345 GMDG_02345 GMDG_08300 GMDG_08300 GMDG_03666 GMDG_03666 GMDG_02973 GMDG_02973 GMDG_03021 GMDG_03021 GMDG_03915 GMDG_03915 cprA cprA GMDG_04019 GMDG_04019 GMDG_04088 GMDG_04088 GMDG_03515 GMDG_03515 GMDG_04160 GMDG_04160 GMDG_04180 GMDG_04180 GMDG_03570 GMDG_03570 GMDG_04357 GMDG_04357 GMDG_03734 GMDG_03734 uba4 uba4 GMDG_05268 GMDG_05268 GMDG_08833 GMDG_08833 GMDG_05696 GMDG_05696 GMDG_05466 GMDG_05466 GMDG_05881 GMDG_05881 GMDG_01173 GMDG_01173 GMDG_06043 GMDG_06043 GMDG_05880 GMDG_05880 GMDG_00989 GMDG_00989 GMDG_01271 GMDG_01271 GMDG_06239 GMDG_06239 GMDG_05442 GMDG_05442 GMDG_06308 GMDG_06308 GMDG_06042 GMDG_06042 GMDG_06373 GMDG_06373 GMDG_06392 GMDG_06392 GMDG_06310 GMDG_06310 GMDG_06140 GMDG_06140 GMDG_01245 GMDG_01245 GMDG_06307 GMDG_06307 GMDG_06357 GMDG_06357 GMDG_01128 GMDG_01128 GMDG_08885 GMDG_08885 GMDG_06563 GMDG_06563 GMDG_06854 GMDG_06854 GMDG_01438 GMDG_01438 GMDG_01548 GMDG_01548 GMDG_06663 GMDG_06663 GMDG_01535 GMDG_01535 GMDG_01555 GMDG_01555 GMDG_06956 GMDG_06956 GMDG_06819 GMDG_06819 GMDG_09070 GMDG_09070 GMDG_01330 GMDG_01330 GMDG_06876 GMDG_06876 COQ6 COQ6 GMDG_06474 GMDG_06474 GMDG_08981 GMDG_08981 GMDG_07108 GMDG_07108 GMDG_00246 GMDG_00246 GMDG_01750 GMDG_01750 GMDG_07543 GMDG_07543 GMDG_01802 GMDG_01802 COQ5 COQ5 GMDG_01749 GMDG_01749
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GMDG_07557Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (539 aa)
GMDG_08507Uncharacterized protein. (758 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (279 aa)
GMDG_02754GST N-terminal domain-containing protein. (334 aa)
GMDG_08590Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (723 aa)
GMDG_02917Uncharacterized protein. (133 aa)
GMDG_08499ACPS domain-containing protein. (346 aa)
GMDG_02701Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (402 aa)
GMDG_02977Carrier domain-containing protein. (1805 aa)
GMDG_02889Uncharacterized protein. (173 aa)
GMDG_02904Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family. (297 aa)
GMDG_08200Methyltransf_25 domain-containing protein. (161 aa)
GMDG_026664-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (411 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (263 aa)
GMDG_02776Uncharacterized protein. (598 aa)
GMDG_03587FAD-binding FR-type domain-containing protein. (615 aa)
GMDG_02728Uncharacterized protein. (2132 aa)
GMDG_00399Uncharacterized protein. (777 aa)
GMDG_00919Uncharacterized protein. (144 aa)
GMDG_08799Uncharacterized protein. (218 aa)
GMDG_08766Rhodanese domain-containing protein. (209 aa)
GMDG_05173Rhodanese domain-containing protein. (405 aa)
GMDG_05443FSH1 domain-containing protein. (229 aa)
GMDG_01036GTP_cyclohydroI domain-containing protein. (305 aa)
GMDG_00008Uncharacterized protein. (342 aa)
GMDG_00006Nudix hydrolase domain-containing protein. (319 aa)
GMDG_00920Metallophos domain-containing protein. (460 aa)
GMDG_05156Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (403 aa)
GMDG_04625Aminotran_5 domain-containing protein. (499 aa)
GMDG_04622Carrier domain-containing protein. (2073 aa)
GMDG_00688Uncharacterized protein. (429 aa)
hxBMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (775 aa)
GMDG_04958CoA carboxyltransferase C-terminal domain-containing protein. (578 aa)
GMDG_04715Uncharacterized protein. (851 aa)
GMDG_04197Uncharacterized protein. (661 aa)
GMDG_04207OHCU_decarbox domain-containing protein. (176 aa)
GMDG_04836Uncharacterized protein. (392 aa)
GMDG_04987Uncharacterized protein. (390 aa)
GMDG_04986Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa)
GMDG_04957Uncharacterized protein. (653 aa)
GMDG_07688FSH1 domain-containing protein. (333 aa)
GMDG_07042Uncharacterized protein. (207 aa)
GMDG_07723Uncharacterized protein. (939 aa)
GMDG_08497Flavoprotein domain-containing protein. (234 aa)
GMDG_01876Uncharacterized protein. (382 aa)
GMDG_07636Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (457 aa)
GMDG_07697Uncharacterized protein. (256 aa)
GMDG_01926Flavin_Reduct domain-containing protein. (279 aa)
GMDG_01925Molecular chaperone HtpG. (703 aa)
GMDG_02084Uncharacterized protein. (75 aa)
GMDG_01987Flavokinase domain-containing protein. (222 aa)
GMDG_02002Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (132 aa)
GMDG_02049Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1189 aa)
GMDG_07868Uncharacterized protein. (2203 aa)
GMDG_02062Uncharacterized protein. (629 aa)
GMDG_05199Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (213 aa)
GMDG_08201Uncharacterized protein. (97 aa)
GMDG_08331Uncharacterized protein. (269 aa)
GMDG_08356Uncharacterized protein. (568 aa)
GMDG_08130Uncharacterized protein. (730 aa)
GMDG_08279Carrier domain-containing protein. (2670 aa)
GMDG_02295Uncharacterized protein. (266 aa)
GMDG_02366Macro domain-containing protein. (309 aa)
GMDG_02345Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (267 aa)
GMDG_08300Uncharacterized protein. (318 aa)
GMDG_03666BPL/LPL catalytic domain-containing protein. (686 aa)
GMDG_02973Uncharacterized protein. (214 aa)
GMDG_03021Pyridoxal kinase. (365 aa)
GMDG_03915Uncharacterized protein. (495 aa)
cprANADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (693 aa)
GMDG_04019Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (633 aa)
GMDG_04088Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (679 aa)
GMDG_03515Nudix hydrolase domain-containing protein. (414 aa)
GMDG_04160Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (328 aa)
GMDG_04180FSH1 domain-containing protein. (271 aa)
GMDG_03570Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (690 aa)
GMDG_04357Uncharacterized protein. (413 aa)
GMDG_03734Nudix hydrolase domain-containing protein. (331 aa)
uba4Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (481 aa)
GMDG_05268Uncharacterized protein. (440 aa)
GMDG_08833Formyl_trans_N domain-containing protein. (124 aa)
GMDG_05696Uncharacterized protein. (336 aa)
GMDG_05466ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (333 aa)
GMDG_05881Methyltransf_25 domain-containing protein. (169 aa)
GMDG_01173Uncharacterized protein. (456 aa)
GMDG_06043MoaC domain-containing protein. (258 aa)
GMDG_05880DFP domain-containing protein. (437 aa)
GMDG_00989Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (308 aa)
GMDG_01271Nicotinate phosphoribosyltransferase. (487 aa)
GMDG_06239Uncharacterized protein. (284 aa)
GMDG_05442Carrier domain-containing protein. (2726 aa)
GMDG_06308Uncharacterized protein. (899 aa)
GMDG_06042Elp3 domain-containing protein. (458 aa)
GMDG_06373Mur_ligase_M domain-containing protein. (345 aa)
GMDG_06392MoCF_biosynth domain-containing protein. (363 aa)
GMDG_06310Carrier domain-containing protein. (1504 aa)
GMDG_06140Uncharacterized protein. (279 aa)
GMDG_01245MFS domain-containing protein. (590 aa)
GMDG_06307FSH1 domain-containing protein. (280 aa)
GMDG_06357Acetyl-CoA carboxylase/biotin carboxylase. (2292 aa)
GMDG_01128Uncharacterized protein; Belongs to the GST superfamily. (605 aa)
GMDG_08885Methyltransf_11 domain-containing protein. (183 aa)
GMDG_06563Uncharacterized protein. (206 aa)
GMDG_06854Cysteine desulfurase. (516 aa)
GMDG_01438Uncharacterized protein. (253 aa)
GMDG_01548NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (236 aa)
GMDG_06663Pyridoxamine 5'-phosphate oxidase. (273 aa)
GMDG_01535Uncharacterized protein. (696 aa)
GMDG_015553-methylcrotonyl-CoA carboxylase beta subunit. (570 aa)
GMDG_06956MINDY_DUB domain-containing protein. (879 aa)
GMDG_06819MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (411 aa)
GMDG_09070Uncharacterized protein. (154 aa)
GMDG_01330Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
GMDG_06876Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. (410 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (489 aa)
GMDG_06474Uncharacterized protein. (244 aa)
GMDG_08981Uncharacterized protein. (77 aa)
GMDG_07108Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (216 aa)
GMDG_00246Uncharacterized protein. (429 aa)
GMDG_01750Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (508 aa)
GMDG_07543Dephospho-CoA kinase. (267 aa)
GMDG_01802Uncharacterized protein. (588 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (318 aa)
GMDG_01749Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (517 aa)
Your Current Organism:
Pseudogymnoascus destructans
NCBI taxonomy Id: 658429
Other names: Geomyces destructans 20631-21, P. destructans 20631-21, Pseudogymnoascus destructans 20631-21
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