95 items (Pseudogymnoascus destructans) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GMDG_00955	Replication factor C subunit 2/4. (357 aa)
	GMDG_00970	RING-box protein 1. (127 aa)
	GMDG_00134	Uncharacterized protein. (1673 aa)
	GMDG_05031	Uncharacterized protein. (408 aa)
	GMDG_05061	DNA_pol_E_B domain-containing protein. (728 aa)
	GMDG_05075	Uncharacterized protein. (237 aa)
	GMDG_05244	CCHC-type domain-containing protein. (361 aa)
	GMDG_05629	Uncharacterized protein. (236 aa)
	GMDG_08809	Uncharacterized protein. (115 aa)
	GMDG_05405	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (673 aa)
	GMDG_05725	CCHC-type domain-containing protein. (124 aa)
	GMDG_01084	DNA helicase; Belongs to the MCM family. (720 aa)
	GMDG_05958	AAA domain-containing protein. (1243 aa)
	GMDG_05775	Uncharacterized protein. (135 aa)
	GMDG_06067	Uncharacterized protein. (228 aa)
	GMDG_08909	Chromo domain-containing protein. (110 aa)
	GMDG_05309	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (546 aa)
	GMDG_05314	Uncharacterized protein. (100 aa)
	GMDG_05459	CCHC-type domain-containing protein. (300 aa)
	GMDG_06129	DNA helicase; Belongs to the MCM family. (1027 aa)
	GMDG_01346	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	GMDG_06622	CCHC-type domain-containing protein. (406 aa)
	GMDG_05905	Uncharacterized protein. (122 aa)
	GMDG_08949	Uncharacterized protein. (120 aa)
	GMDG_01462	Uncharacterized protein. (286 aa)
	GMDG_01277	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (403 aa)
	GMDG_01292	CCHC-type domain-containing protein. (437 aa)
	GMDG_07422	CCHC-type domain-containing protein. (300 aa)
	GMDG_07452	Uncharacterized protein. (447 aa)
	GMDG_07234	CCHC-type domain-containing protein. (390 aa)
	GMDG_07523	DNA polymerase. (1102 aa)
	GMDG_07538	CCHC-type domain-containing protein. (380 aa)
	GMDG_07500	CCHC-type domain-containing protein. (287 aa)
	GMDG_01907	Uncharacterized protein. (431 aa)
	GMDG_01879	Uncharacterized protein. (237 aa)
	GMDG_07489	Uncharacterized protein. (516 aa)
	GMDG_01774	Uncharacterized protein. (108 aa)
	GMDG_02035	Cell division control protein; Belongs to the CDC6/cdc18 family. (641 aa)
	GMDG_07576	Replication factor C subunit 1. (1046 aa)
	GMDG_08034	CCHC-type domain-containing protein. (427 aa)
	GMDG_02017	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily. (330 aa)
	GMDG_01806	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (669 aa)
	GMDG_08061	DNA polymerase. (1445 aa)
	GMDG_01923	CMGC/CDK/CDK5 protein kinase; Belongs to the protein kinase superfamily. (318 aa)
	GMDG_02480	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (608 aa)
	GMDG_02005	Zds_C domain-containing protein. (919 aa)
	GMDG_02083	BZIP domain-containing protein. (212 aa)
	GMDG_08532	CCHC-type domain-containing protein. (393 aa)
	GMDG_08020	Sld5 domain-containing protein. (268 aa)
	GMDG_08339	Uncharacterized protein. (67 aa)
	GMDG_02762	Uncharacterized protein. (364 aa)
	GMDG_02759	Uncharacterized protein. (184 aa)
	GMDG_03071	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2224 aa)
	GMDG_03083	CCHC-type domain-containing protein. (210 aa)
	GMDG_02989	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa)
	GMDG_03022	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (912 aa)
	GMDG_00444	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (489 aa)
	GMDG_00489	DNA replication complex GINS protein PSF1. (225 aa)
	GMDG_02760	Uncharacterized protein. (301 aa)
	GMDG_02856	Uncharacterized protein. (451 aa)
	GMDG_03286	DNA helicase; Belongs to the MCM family. (868 aa)
	GMDG_08621	Uncharacterized protein. (95 aa)
	GMDG_08665	Chromo domain-containing protein. (198 aa)
	GMDG_08668	CCHC-type domain-containing protein. (355 aa)
	GMDG_03360	Replication factor C subunit 5. (352 aa)
	GMDG_03391	Polyubiquitin. (381 aa)
	GMDG_03508	CCHC-type domain-containing protein. (393 aa)
	GMDG_03758	DNA helicase; Belongs to the MCM family. (947 aa)
	GMDG_02864	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (783 aa)
	GMDG_00597	DNA ligase. (930 aa)
	GMDG_03916	BZIP domain-containing protein. (409 aa)
	GMDG_03479	Replication factor C subunit 3/5. (393 aa)
	GMDG_08675	Chromo domain-containing protein. (210 aa)
	GMDG_03946	DNA helicase; Belongs to the MCM family. (854 aa)
	GMDG_03719	Amino_oxidase domain-containing protein. (581 aa)
	GMDG_03757	Uncharacterized protein. (460 aa)
	GMDG_08682	Uncharacterized protein. (351 aa)
	GMDG_00510	Uncharacterized protein. (894 aa)
	GMDG_08706	CCHC-type domain-containing protein. (323 aa)
	GMDG_08652	Uncharacterized protein. (121 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (810 aa)
	GMDG_08710	Uncharacterized protein. (91 aa)
	GMDG_04440	Uncharacterized protein. (564 aa)
	GMDG_04500	CCHC-type domain-containing protein. (410 aa)
	GMDG_04437	Uncharacterized protein. (661 aa)
	GMDG_08717	Uncharacterized protein. (210 aa)
	GMDG_04087	CBFD_NFYB_HMF domain-containing protein. (199 aa)
	GMDG_04267	CBFD_NFYB_HMF domain-containing protein. (235 aa)
	GMDG_04737	AAA domain-containing protein. (389 aa)
	GMDG_04371	Chromo domain-containing protein. (118 aa)
	GMDG_04428	Sld5 domain-containing protein. (190 aa)
	GMDG_04904	CCHC-type domain-containing protein. (379 aa)
	GMDG_04669	DNA ligase. (883 aa)
	GMDG_04883	Uncharacterized protein. (472 aa)

Your Current Organism:

Pseudogymnoascus destructans

NCBI taxonomy Id: 658429
Other names: Geomyces destructans 20631-21, P. destructans 20631-21, Pseudogymnoascus destructans 20631-21

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	GMDG_00134	L8FSI2	L8FMQ8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.974
FEN1	GMDG_00597	L8FSI2	L8G7X3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.980
FEN1	GMDG_00955	L8FSI2	L8FMN4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 2/4.	0.930
FEN1	GMDG_00970	L8FSI2	L8FMP8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	RING-box protein 1.	0.516
FEN1	GMDG_01084	L8FSI2	L8FPW0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.912
FEN1	GMDG_01806	L8FSI2	L8G119	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.846
FEN1	GMDG_01907	L8FSI2	L8FY53	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.847
FEN1	GMDG_01923	L8FSI2	L8G1V7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	CMGC/CDK/CDK5 protein kinase; Belongs to the protein kinase superfamily.	0.482
FEN1	GMDG_02017	L8FSI2	L8G0B0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily.	0.482
FEN1	GMDG_02035	L8FSI2	L8FZ04	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.696
FEN1	GMDG_02480	L8FSI2	L8G203	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.856
FEN1	GMDG_02864	L8FSI2	L8G7N2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.548
FEN1	GMDG_03022	L8FSI2	L8G521	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.999
FEN1	GMDG_03071	L8FSI2	L8G4R0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.920
FEN1	GMDG_03286	L8FSI2	L8G5U0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.885
FEN1	GMDG_03360	L8FSI2	L8G761	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 5.	0.945
FEN1	GMDG_03479	L8FSI2	L8G832	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 3/5.	0.890
FEN1	GMDG_03757	L8FSI2	L8G8K4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.840
FEN1	GMDG_03758	L8FSI2	L8G7I8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.895
FEN1	GMDG_03946	L8FSI2	L8G8G1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.921