96 items (Pseudogymnoascus destructans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GMDG_08621	Uncharacterized protein. (95 aa)
	GMDG_08665	Chromo domain-containing protein. (198 aa)
	GMDG_00533	Uncharacterized protein. (176 aa)
	GMDG_08668	CCHC-type domain-containing protein. (355 aa)
	GMDG_03360	Replication factor C subunit 5. (352 aa)
	GMDG_03508	CCHC-type domain-containing protein. (393 aa)
	GMDG_03753	Uncharacterized protein. (154 aa)
	GMDG_03758	DNA helicase; Belongs to the MCM family. (947 aa)
	GMDG_00597	DNA ligase. (930 aa)
	GMDG_03479	Replication factor C subunit 3/5. (393 aa)
	GMDG_08675	Chromo domain-containing protein. (210 aa)
	GMDG_03946	DNA helicase; Belongs to the MCM family. (854 aa)
	GMDG_03719	Amino_oxidase domain-containing protein. (581 aa)
	GMDG_03757	Uncharacterized protein. (460 aa)
	GMDG_08682	Uncharacterized protein. (351 aa)
	GMDG_04103	Exo84_C domain-containing protein. (672 aa)
	GMDG_08706	CCHC-type domain-containing protein. (323 aa)
	GMDG_03367	AAA domain-containing protein. (533 aa)
	GMDG_08652	Uncharacterized protein. (121 aa)
	GMDG_03881	Uncharacterized protein. (286 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (810 aa)
	GMDG_08710	Uncharacterized protein. (91 aa)
	GMDG_04440	Uncharacterized protein. (564 aa)
	GMDG_00700	Uncharacterized protein. (137 aa)
	GMDG_04500	CCHC-type domain-containing protein. (410 aa)
	GMDG_04437	Uncharacterized protein. (661 aa)
	GMDG_08717	Uncharacterized protein. (210 aa)
	GMDG_04087	CBFD_NFYB_HMF domain-containing protein. (199 aa)
	GMDG_04267	CBFD_NFYB_HMF domain-containing protein. (235 aa)
	GMDG_04737	AAA domain-containing protein. (389 aa)
	GMDG_04371	Chromo domain-containing protein. (118 aa)
	GMDG_04904	CCHC-type domain-containing protein. (379 aa)
	GMDG_04669	DNA ligase. (883 aa)
	GMDG_04883	Uncharacterized protein. (472 aa)
	GMDG_04336	Uncharacterized protein. (137 aa)
	GMDG_00955	Replication factor C subunit 2/4. (357 aa)
	GMDG_00134	Uncharacterized protein. (1673 aa)
	GMDG_05031	Uncharacterized protein. (408 aa)
	GMDG_05061	DNA_pol_E_B domain-containing protein. (728 aa)
	GMDG_05075	Uncharacterized protein. (237 aa)
	GMDG_05244	CCHC-type domain-containing protein. (361 aa)
	GMDG_08809	Uncharacterized protein. (115 aa)
	GMDG_05725	CCHC-type domain-containing protein. (124 aa)
	GMDG_01084	DNA helicase; Belongs to the MCM family. (720 aa)
	GMDG_00112	Uncharacterized protein. (375 aa)
	GMDG_05958	AAA domain-containing protein. (1243 aa)
	GMDG_05775	Uncharacterized protein. (135 aa)
	GMDG_06067	Uncharacterized protein. (228 aa)
	GMDG_08909	Chromo domain-containing protein. (110 aa)
	GMDG_05309	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (546 aa)
	GMDG_05314	Uncharacterized protein. (100 aa)
	GMDG_01288	Uncharacterized protein. (483 aa)
	GMDG_01212	DNA polymerase. (1742 aa)
	GMDG_05459	CCHC-type domain-containing protein. (300 aa)
	GMDG_06129	DNA helicase; Belongs to the MCM family. (1027 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	GMDG_06622	CCHC-type domain-containing protein. (406 aa)
	GMDG_05905	Uncharacterized protein. (122 aa)
	GMDG_01462	Uncharacterized protein. (286 aa)
	GMDG_01292	CCHC-type domain-containing protein. (437 aa)
	GMDG_06319	Fungal_trans domain-containing protein. (584 aa)
	GMDG_07248	Uncharacterized protein. (256 aa)
	GMDG_07422	CCHC-type domain-containing protein. (300 aa)
	GMDG_07452	Uncharacterized protein. (447 aa)
	GMDG_07234	CCHC-type domain-containing protein. (390 aa)
	GMDG_07523	DNA polymerase. (1102 aa)
	GMDG_07538	CCHC-type domain-containing protein. (380 aa)
	GMDG_07500	CCHC-type domain-containing protein. (287 aa)
	GMDG_01907	Uncharacterized protein. (431 aa)
	GMDG_01879	Uncharacterized protein. (237 aa)
	GMDG_07489	Uncharacterized protein. (516 aa)
	GMDG_01774	Uncharacterized protein. (108 aa)
	GMDG_07718	RNase H domain-containing protein. (162 aa)
	GMDG_07576	Replication factor C subunit 1. (1046 aa)
	GMDG_01861	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (162 aa)
	GMDG_08034	CCHC-type domain-containing protein. (427 aa)
	GMDG_01806	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (669 aa)
	GMDG_08061	DNA polymerase. (1445 aa)
	GMDG_02212	Uncharacterized protein. (178 aa)
	GMDG_02480	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (608 aa)
	GMDG_02005	Zds_C domain-containing protein. (919 aa)
	GMDG_02366	Macro domain-containing protein. (309 aa)
	GMDG_08532	CCHC-type domain-containing protein. (393 aa)
	GMDG_08015	Uncharacterized protein. (1055 aa)
	GMDG_08339	Uncharacterized protein. (67 aa)
	GMDG_02762	Uncharacterized protein. (364 aa)
	GMDG_08064	Uncharacterized protein. (347 aa)
	GMDG_02759	Uncharacterized protein. (184 aa)
	GMDG_03071	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2224 aa)
	GMDG_03083	CCHC-type domain-containing protein. (210 aa)
	GMDG_03022	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (912 aa)
	GMDG_02760	Uncharacterized protein. (301 aa)
	GMDG_02856	Uncharacterized protein. (451 aa)
	GMDG_03286	DNA helicase; Belongs to the MCM family. (868 aa)
	GMDG_02886	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (397 aa)
	GMDG_02925	Zn(2)-C6 fungal-type domain-containing protein. (743 aa)

Your Current Organism:

Pseudogymnoascus destructans

NCBI taxonomy Id: 658429
Other names: Geomyces destructans 20631-21, P. destructans 20631-21, Pseudogymnoascus destructans 20631-21

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	GMDG_00112	L8FSI2	L8FPW2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.534
FEN1	GMDG_00134	L8FSI2	L8FMQ8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.974
FEN1	GMDG_00533	L8FSI2	L8G6J5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.467
FEN1	GMDG_00597	L8FSI2	L8G7X3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.980
FEN1	GMDG_00955	L8FSI2	L8FMN4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 2/4.	0.930
FEN1	GMDG_01084	L8FSI2	L8FPW0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.912
FEN1	GMDG_01212	L8FSI2	L8FRP2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.846
FEN1	GMDG_01806	L8FSI2	L8G119	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.846
FEN1	GMDG_01907	L8FSI2	L8FY53	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.847
FEN1	GMDG_02480	L8FSI2	L8G203	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.856
FEN1	GMDG_02886	L8FSI2	L8G5U5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.735
FEN1	GMDG_02925	L8FSI2	L8G619	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Zn(2)-C6 fungal-type domain-containing protein.	0.425
FEN1	GMDG_03022	L8FSI2	L8G521	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.999
FEN1	GMDG_03071	L8FSI2	L8G4R0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.920
FEN1	GMDG_03286	L8FSI2	L8G5U0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.885
FEN1	GMDG_03360	L8FSI2	L8G761	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 5.	0.945
FEN1	GMDG_03479	L8FSI2	L8G832	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 3/5.	0.890
FEN1	GMDG_03757	L8FSI2	L8G8K4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.840
FEN1	GMDG_03758	L8FSI2	L8G7I8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.895
FEN1	GMDG_03881	L8FSI2	L8G9I7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.864