(67 nodes) Methane metabolism network (Fusarium oxysporum Fo5176)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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	FOXB_00227	Probable acetate kinase. (877 aa)
	FOXB_00670	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (289 aa)
	FOXB_01286	PNPLA domain-containing protein. (620 aa)
	FOXB_01841	Uncharacterized protein. (600 aa)
	FOXB_01842	Zn(2)-C6 fungal-type domain-containing protein. (589 aa)
	FOXB_01843	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (305 aa)
	FOXB_01903	GMC_OxRdtase_N domain-containing protein. (677 aa)
	FOXB_02237	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (473 aa)
	FOXB_02456	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (384 aa)
	FOXB_03469	Zn(2)-C6 fungal-type domain-containing protein. (1306 aa)
	FOXB_03470	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (280 aa)
	FOXB_03471	TRANSKETOLASE_1 domain-containing protein. (550 aa)
	FOXB_03764	PNPLA domain-containing protein. (788 aa)
	FOXB_03989	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (365 aa)
	FOXB_04223	Uncharacterized protein. (398 aa)
	FOXB_04260	TRANSKETOLASE_1 domain-containing protein. (727 aa)
	FOXB_04369	Uncharacterized protein. (391 aa)
	FOXB_04404	Uncharacterized protein. (1054 aa)
	FOXB_04764	Uncharacterized protein. (448 aa)
	FOXB_04933	C2H2-type domain-containing protein. (607 aa)
	FOXB_05311	Uncharacterized protein. (797 aa)
	FOXB_05504	PKS_ER domain-containing protein. (420 aa)
	FOXB_05660	GFA domain-containing protein. (271 aa)
	FOXB_05929	Putative glutathione-dependent formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family. (227 aa)
	FOXB_06136	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (232 aa)
	FOXB_06448	GFA domain-containing protein. (138 aa)
	FOXB_06491	Aminotran_5 domain-containing protein. (460 aa)
	FOXB_07114	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (783 aa)
	FOXB_07134	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (569 aa)
	FOXB_07208	PEP-utilizers_C domain-containing protein. (136 aa)
	FOXB_07313	GFA domain-containing protein. (137 aa)
	FOXB_07658	Uncharacterized protein. (579 aa)
	FOXB_07776	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	FOXB_07830	Uncharacterized protein. (330 aa)
	FOXB_07983	FBPase domain-containing protein; Belongs to the FBPase class 1 family. (342 aa)
	FOXB_08437	Acetyl-coenzyme A synthetase. (719 aa)
	FOXB_08466	Uncharacterized protein. (161 aa)
	FOXB_09167	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (518 aa)
	FOXB_09635	PNPLA domain-containing protein. (589 aa)
	FOXB_10286	GMC_OxRdtase_N domain-containing protein. (610 aa)
	FOXB_10695	PNPLA domain-containing protein. (445 aa)
	FOXB_10715	PNPLA domain-containing protein. (359 aa)
	FOXB_11049	Uncharacterized protein. (427 aa)
	FOXB_11052	Uncharacterized protein. (657 aa)
	FOXB_11275	GFA domain-containing protein. (136 aa)
	FOXB_11494	Uncharacterized protein. (532 aa)
	FOXB_11561	Uncharacterized protein. (938 aa)
	FOXB_11779	Uncharacterized protein. (478 aa)
	FOXB_12164	PNPLA domain-containing protein. (1053 aa)
	FOXB_13424	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (505 aa)
	FOXB_13951	Acetyl-coenzyme A synthetase. (663 aa)
	FOXB_14027	Uncharacterized protein. (643 aa)
	FOXB_14390	GFA domain-containing protein. (138 aa)
	FOXB_14531	Uncharacterized protein; Belongs to the zinc-containing alcohol dehydrogenase family. (1100 aa)
	FOXB_14813	Uncharacterized protein. (786 aa)
	FOXB_15032	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (285 aa)
	FOXB_15150	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
	FOXB_15512	PNPLA domain-containing protein. (606 aa)
	FOXB_16145	PNPLA domain-containing protein. (953 aa)
	FOXB_16202	Uncharacterized protein. (803 aa)
	FOXB_16701	Uncharacterized protein. (244 aa)
	FOXB_16728	Uncharacterized protein. (250 aa)
	FOXB_16941	PNPLA domain-containing protein. (578 aa)
	FOXB_16942	PNPLA domain-containing protein. (366 aa)
	FOXB_16992	PNPLA domain-containing protein. (380 aa)
	FOXB_17280	PNPLA domain-containing protein. (373 aa)
	FOXB_17751	DUF659 domain-containing protein. (404 aa)

Your Current Organism:

Fusarium oxysporum Fo5176

NCBI taxonomy Id: 660025
Other names: F. oxysporum Fo5176

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXB_00227	FOXB_08437	F9F1E1	F9FPV7	Probable acetate kinase.	Acetyl-coenzyme A synthetase.	0.772
FOXB_00227	FOXB_13951	F9F1E1	F9G5L9	Probable acetate kinase.	Acetyl-coenzyme A synthetase.	0.772
FOXB_00670	FOXB_01841	F9F2P6	F9F616	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Uncharacterized protein.	0.773
FOXB_00670	FOXB_01842	F9F2P6	F9F617	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Zn(2)-C6 fungal-type domain-containing protein.	0.856
FOXB_00670	FOXB_01843	F9F2P6	F9F618	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	0.737
FOXB_00670	FOXB_03469	F9F2P6	F9FAP3	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Zn(2)-C6 fungal-type domain-containing protein.	0.855
FOXB_00670	FOXB_03470	F9F2P6	F9FAP4	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	0.731
FOXB_00670	FOXB_03471	F9F2P6	F9FAP5	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	TRANSKETOLASE_1 domain-containing protein.	0.855
FOXB_00670	FOXB_03989	F9F2P6	F9FC61	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.774
FOXB_00670	FOXB_04260	F9F2P6	F9FCY2	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	TRANSKETOLASE_1 domain-containing protein.	0.855
FOXB_00670	FOXB_04369	F9F2P6	F9FD91	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Uncharacterized protein.	0.772
FOXB_00670	FOXB_04764	F9F2P6	F9FED6	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Uncharacterized protein.	0.942
FOXB_00670	FOXB_06136	F9F2P6	F9FIA7	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.885
FOXB_00670	FOXB_06491	F9F2P6	F9FJB2	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Aminotran_5 domain-containing protein.	0.582
FOXB_00670	FOXB_07114	F9F2P6	F9FL35	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.909
FOXB_00670	FOXB_07658	F9F2P6	F9FMM8	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Uncharacterized protein.	0.773
FOXB_00670	FOXB_07830	F9F2P6	F9FN49	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Uncharacterized protein.	0.772
FOXB_00670	FOXB_07983	F9F2P6	F9FNK3	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	FBPase domain-containing protein; Belongs to the FBPase class 1 family.	0.875
FOXB_00670	FOXB_08437	F9F2P6	F9FPV7	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Acetyl-coenzyme A synthetase.	0.770
FOXB_00670	FOXB_11494	F9F2P6	F9FYL2	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Uncharacterized protein.	0.842