STRINGSTRING
dnaA dnaA dnaX dnaX priA priA AFK06048.1 AFK06048.1 AFK06057.1 AFK06057.1 smc smc lexA lexA gyrA gyrA AFK06365.1 AFK06365.1 AFK06388.1 AFK06388.1 AFK06428.1 AFK06428.1 ligA ligA AFK06473.1 AFK06473.1 AFK06474.1 AFK06474.1 AFK06491.1 AFK06491.1 AFK06657.1 AFK06657.1 AFK06736.1 AFK06736.1 AFK06744.1 AFK06744.1 polA polA dnaG dnaG gyrB gyrB AFK07023.1 AFK07023.1 AFK07075.1 AFK07075.1 dnaJ dnaJ AFK07185.1 AFK07185.1 polC polC AFK07230.1 AFK07230.1 AFK07946.1 AFK07946.1 AFK08268.1 AFK08268.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (447 aa)
dnaXDNA polymerase III, subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (485 aa)
priAReplication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (758 aa)
AFK06048.1Putative S-layer protein; PFAM: S-layer homology domain. (562 aa)
AFK06057.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (449 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1174 aa)
lexASOS regulatory protein LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (208 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (808 aa)
AFK06365.1PFAM: Bacterial DNA polymerase III alpha subunit. (898 aa)
AFK06388.1DNA polymerase III, delta subunit. (313 aa)
AFK06428.1DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (367 aa)
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (665 aa)
AFK06473.1Ribonucleoside-triphosphate reductase class III catalytic subunit; PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase. (717 aa)
AFK06474.1PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. (182 aa)
AFK06491.1PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. (185 aa)
AFK06657.1PFAM: Single-strand binding protein family; TIGRFAM: single stranded DNA-binding protein (ssb). (153 aa)
AFK06736.1PFAM: MgsA AAA+ ATPase C terminal; Holliday junction DNA helicase ruvB N-terminus. (437 aa)
AFK06744.1Putative S-layer protein; PFAM: S-layer homology domain. (579 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (896 aa)
dnaGDNA primase, catalytic core; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (569 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (631 aa)
AFK07023.1Hypothetical protein. (342 aa)
AFK07075.1Hypothetical protein. (704 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (375 aa)
AFK07185.1nucleotidyltransferase/DNA polymerase involved in DNA repair; PFAM: impB/mucB/samB family C-terminal; impB/mucB/samB family; IMS family HHH motif; Belongs to the DNA polymerase type-Y family. (412 aa)
polCDNA polymerase III, alpha chain; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1412 aa)
AFK07230.1Hypothetical protein. (348 aa)
AFK07946.1Hypothetical protein. (395 aa)
AFK08268.1DNA repair exonuclease. (388 aa)
Your Current Organism:
Mesotoga prima
NCBI taxonomy Id: 660470
Other names: M. prima MesG1.Ag.4.2, Mesotoga prima MesG1.Ag.4.2, Thermotogales bacterium MesG1.Ag.4.2
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.