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fumC fumC tpi tpi sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB sucA sucA sucB sucB sucC sucC sucD sucD prs prs sfcA sfcA LLO_0452 LLO_0452 rpe rpe LLO_0636 LLO_0636 LLO_0659 LLO_0659 sdhB-2 sdhB-2 sdhC-2 sdhC-2 sdhD-2 sdhD-2 sdhA-2 sdhA-2 pgi pgi sfcA-2 sfcA-2 pfp pfp poxB poxB odp odp LLO_1518 LLO_1518 odpA odpA ydgR ydgR mnmC mnmC prpB prpB prpC prpC prpD prpD LLO_1562 LLO_1562 LLO_1668 LLO_1668 acnA-2 acnA-2 lpd lpd aceF aceF aceE aceE cdd cdd deoC deoC gltA gltA yneI yneI LLO_1948 LLO_1948 LLO_1949 LLO_1949 LLO_1955 LLO_1955 icd icd ppsA ppsA LLO_2198 LLO_2198 LLO_2199 LLO_2199 eno eno LLO_2561 LLO_2561 deoB deoB LLO_2717 LLO_2717 ywtG ywtG eda eda glk glk edd edd pgl pgl zwf zwf mdh mdh acnA-3 acnA-3 LLO_2975 LLO_2975 capP capP tkt tkt gap gap pgk pgk pykA pykA rpiA rpiA LLO_3344 LLO_3344
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
tpiTriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
sdhCSuccinate dehydrogenase, cytochrome b556 subunit; Equals llo0393. (124 aa)
sdhDSuccinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Equals llo0395; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (589 aa)
sdhBSuccinate dehydrogenase, iron sulfur protein; Equals llo0396. (240 aa)
sucA2-oxoglutarate dehydrogenase, E1 subunit; Equals llo0397. (934 aa)
sucBDihydrolipoamide succinyltransferase, E2 subunit; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
sfcAMalate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme); Equals llo0429. (569 aa)
LLO_0452Putative aconitate hydratase; Equals llo0452. (647 aa)
rpeRibulose-phosphate 3-epimerase; Equals llo0610; Belongs to the ribulose-phosphate 3-epimerase family. (217 aa)
LLO_06362-oxoisovalerate dehydrogenase E1 component; Equals llo0636; similar to pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (745 aa)
LLO_0659Putative NADP-dependent malic enzyme; Equals llo0659. (474 aa)
sdhB-2Succinate dehydrogenase, iron sulfur protein; Equals llo0661. (232 aa)
sdhC-2Succinate dehydrogenase, cytochrome b556 subunit; Equals llo0662. (124 aa)
sdhD-2Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (119 aa)
sdhA-2Succinate dehydrogenase flavoprotein subunit; Equals llo0664; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (586 aa)
pgiGlucose-6-phosphate isomerase; Equals llo0884; Belongs to the GPI family. (483 aa)
sfcA-2Malate oxidoreductase; Equals llo1147. (572 aa)
pfpPutative PPi dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (414 aa)
poxBPyruvate dehydrogenase (pyruvate oxidase), thiamin-dependent, FAD-binding; Equals llo1357; Belongs to the TPP enzyme family. (575 aa)
odpBranched-chain alpha-keto acid dehydrogenase subunit E2; Equals llo1517; pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase). (370 aa)
LLO_1518Equals llo1518; similar to pyruvate dehydrogenase E1 (beta subunit). (324 aa)
odpAPyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (357 aa)
ydgRPeptide transport protein; Equals llo1553. (495 aa)
mnmCPutative FAD dependent oxidoreductase; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family. (669 aa)
prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (294 aa)
prpC2-methylcitrate synthase; Equals llo1556; Belongs to the citrate synthase family. (372 aa)
prpD2-methylcitrate dehydratase; Equals llo1557. (483 aa)
LLO_1562Putative ribose/galactose isomerase; Equals llo1562. (147 aa)
LLO_1668Putative NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (394 aa)
acnA-2Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
lpdLipoamide dehydrogenase, E3 component is part of three enzyme complexes; Equals llo1759. (479 aa)
aceFPyruvate dehydrogenase (dihydrolipoyltransacetylase component) E2p; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (541 aa)
aceEPyruvate dehydrogenase (decarboxylase component) E1p; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (131 aa)
deoC2-deoxyribose-5-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (254 aa)
gltACitrate synthase; Equals llo1803; Belongs to the citrate synthase family. (423 aa)
yneIEquals llo1805; similar to aldehyde dehydrogenase. (457 aa)
LLO_1948Equals llo1948; Simiar to 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (322 aa)
LLO_1949Equals llo1949; similar to 2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (602 aa)
LLO_1955Equals llo1955; similar to keto-hydroxyglutarate aldolase. (185 aa)
icdIsocitrate dehydrogenase; Equals llo2043. (418 aa)
ppsAPutative phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa)
LLO_2198Putative thymidine/pyrimidine-nucleoside phosphorylase; Equals llo2198. (506 aa)
LLO_2199Putative ribose-phosphate pyrophosphokinase; Equals llo2199; Belongs to the ribose-phosphate pyrophosphokinase family. (298 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (422 aa)
LLO_2561Equals llo2561; similar to NADP-dependent malic enzyme. (407 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa)
LLO_2717Equals llo2717; similar to fructose-bisphosphate aldolase. (336 aa)
ywtGD-xylose (galactose, arabinose)-proton symporter; Equals llo2802; similar to sugar transport protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (472 aa)
edaEquals llo2803; similar to 2-deydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase. (217 aa)
glkEquals llo2804; similar to glucokinase; Belongs to the bacterial glucokinase family. (334 aa)
eddPutative 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (611 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (230 aa)
zwfPutative Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
acnA-3Putative transposase (C-terminal part); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (946 aa)
LLO_2975Equals llo2975; similar to oxydoreductase. (465 aa)
capPPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (771 aa)
tktPutative transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; Equals llo3262; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa)
pgkPhosphoglycerate kinase; Equals llo3263; Belongs to the phosphoglycerate kinase family. (396 aa)
pykAPyruvate kinase II; Equals llo3264; similar to pyruvate kinase II PykA, glucose stimulated. (472 aa)
rpiARibose 5-phosphate isomerase, constitutive; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (216 aa)
LLO_3344Hypothetical protein; Equals llo3344. (706 aa)
Your Current Organism:
Legionella longbeachae
NCBI taxonomy Id: 661367
Other names: L. longbeachae NSW150, Legionella longbeachae NSW150, Legionella longbeachae str. NSW150, Legionella longbeachae strain NSW150
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