STRINGSTRING
LLO_1082 LLO_1082 LLO_1106 LLO_1106 LLO_1107 LLO_1107 LLO_1135 LLO_1135 hmgA hmgA dnaN dnaN LLO_0010 LLO_0010 LLO_0068 LLO_0068 dcd dcd fumC fumC tatC tatC LLO_0139 LLO_0139 LLO_0140 LLO_0140 tatB tatB ruvC ruvC tatA tatA ubiE ubiE coxC coxC priA priA LLO_0205 LLO_0205 LLO_0222 LLO_0222 typA typA hda hda nuoE nuoE nuoF nuoF nuoG nuoG nuoL nuoL nuoM nuoM dnaX dnaX fabI fabI atpB atpB LLO_0316 LLO_0316 LLO_0317 LLO_0317 LLO_0318 LLO_0318 LLO_0319 LLO_0319 atpA atpA rpsI rpsI petB petB mutL mutL LLO_0380 LLO_0380 sdhC sdhC sdhA sdhA sucA sucA sucB sucB sucC sucC sucD sucD pdxH pdxH fis fis prs prs LLO_0422 LLO_0422 LLO_0423 LLO_0423 LLO_0442 LLO_0442 indA indA ppk ppk rplA rplA rplJ rplJ rpoB rpoB rpoC rpoC rpsL rpsL rpsL-2 rpsL-2 rplB rplB rpsS rpsS rplV rplV rplN rplN rpsE rpsE rpmD rpmD rplO rplO secY secY rpsD rpsD rpoA rpoA smpA smpA LLO_0546 LLO_0546 uvrA uvrA bioC bioC xseB xseB gpsA gpsA lolE lolE sdhC-2 sdhC-2 sdhA-2 sdhA-2 LLO_0665 LLO_0665 rtcB rtcB LLO_0716 LLO_0716 LLO_0736 LLO_0736 thiJ thiJ acrA acrA dnaB dnaB LLO_0843 LLO_0843 LLO_0871 LLO_0871 galU galU recQ recQ rpoZ rpoZ thiS thiS LLO_0980 LLO_0980 LLO_0981 LLO_0981 fabI-2 fabI-2 uvrD uvrD mccA mccA LLO_1075 LLO_1075 LLO_1076 LLO_1076 rnpA rnpA atpB-2 atpB-2 atpE atpE atpF atpF atpH atpH atpA-2 atpA-2 atpG atpG atpD atpD atpC atpC parC parC LLO_3401 LLO_3401 LLO_3400 LLO_3400 LLO_3373 LLO_3373 LLO_3363 LLO_3363 uvrB uvrB LLO_3344 LLO_3344 ubiH ubiH visC visC LLO_3299 LLO_3299 gcsB gcsB gcsA gcsA gcvH gcvH LLO_3272 LLO_3272 galU-2 galU-2 bexD bexD glsA glsA budB budB sufB sufB sufC sufC sufD sufD dfp dfp LLO_3029 LLO_3029 LLO_3025 LLO_3025 LLO_2970 LLO_2970 traI traI traC-2 traC-2 LLO_2869 LLO_2869 LLO_2866 LLO_2866 dnaG dnaG ffh ffh yadG yadG yadH yadH ompR ompR LLO_2772 LLO_2772 accC accC accB accB yhbH yhbH rpoN rpoN yggH yggH yaeT yaeT LLO_2674 LLO_2674 LLO_2668 LLO_2668 LLO_2659 LLO_2659 uvrC uvrC holC holC LLO_2603 LLO_2603 cydB cydB cydA cydA potA potA LLO_2576 LLO_2576 hslV hslV hslU hslU wrbA wrbA mdcC mdcC mdcE mdcE eno eno recG recG carA carA hypE hypE hypF hypF hypA hypA LLO_2373 LLO_2373 LLO_2372 LLO_2372 accD accD LLO_2337 LLO_2337 ycaJ ycaJ LLO_2305 LLO_2305 gatA gatA LLO_2286 LLO_2286 LLO_2284 LLO_2284 LLO_2283 LLO_2283 yecS yecS ugpE ugpE ugpC ugpC guaB guaB iolD iolD LLO_2215 LLO_2215 LLO_2170 LLO_2170 qxtA qxtA LLO_2091 LLO_2091 accA accA LLO_2049 LLO_2049 xseA xseA trpG trpG lptB lptB yrbE yrbE LLO_2017 LLO_2017 LLO_1987 LLO_1987 hbpA hbpA LLO_1863 LLO_1863 LLO_1831 LLO_1831 gyrA gyrA rpsA rpsA aceE aceE aceF aceF rpsB rpsB LLO_1673 LLO_1673 LLO_1671 LLO_1671 LLO_1667 LLO_1667 LLO_1607 LLO_1607 LLO_1573 LLO_1573 LLO_1533 LLO_1533 odp odp ruvB ruvB glpD glpD LLO_1488 LLO_1488 rpmF rpmF fis-2 fis-2 lspG lspG lspH lspH lspI lspI lspJ lspJ rir1 rir1 LLO_1416 LLO_1416 LLO_1378 LLO_1378 ytfH ytfH poxB poxB bamD bamD clpX clpX LLO_1274 LLO_1274 LLO_1273 LLO_1273 LLO_1263 LLO_1263 LLO_1262 LLO_1262 LLO_1195 LLO_1195 lspD lspD qseB qseB ruvA ruvA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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LLO_1082Hypothetical protein of unknown function; Equals llo1082. (260 aa)
LLO_1106Hypothetical protein; Equals llo1106. (727 aa)
LLO_1107Putative surface antigen; Equals llo1107. (563 aa)
LLO_1135Equals llo1135; similar to transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (304 aa)
hmgAHomogentisate 1,2-dioxygenase; Equals llo1153. (418 aa)
dnaNDNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (367 aa)
LLO_0010Hypothetical protein, carbohydrate-selective porin OprB domain; Equals llo0010. (438 aa)
LLO_0068Equals llo0068; conserved hypothetical protein. (530 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
tatCPutative Sec-independent protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (234 aa)
LLO_0139Hypothetical protein; Equals llo0139. (183 aa)
LLO_0140Hypothetical protein; Equals llo0140. (189 aa)
tatBPutative TatB protein (twin arginine translocation); Equals llo0141. (75 aa)
ruvCCrossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (172 aa)
tatAPutative TatA protein(twin arginine translocation); Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (60 aa)
ubiEUbiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (250 aa)
coxCCytochrome c oxidase, subunit III; Equals llo0154. (289 aa)
priAPrimosomal protein N' (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (753 aa)
LLO_0205Equals llo0205; similar to guanosine monophosphate reductase GuaC. (336 aa)
LLO_0222Putative methyltransferase; Equals llo0222. (244 aa)
typAEquals llo0249; similar to GTP-binding protein TypA/BipA. (608 aa)
hdaATPase regulatory factor involved in DnaA inactivation; Equals llo0268; Belongs to the DnaA family. HdA subfamily. (230 aa)
nuoENADH dehydrogenase I chain E; Equals llo0281. (167 aa)
nuoFNADH dehydrogenase I chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (425 aa)
nuoGNADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (784 aa)
nuoLNADH-quinone oxidoreductase chain L; Equals llo0288. (657 aa)
nuoMNADH-quinone oxidoreductase chain M; Equals llo0289. (501 aa)
dnaXDNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (549 aa)
fabIEnoyl-[acyl-carrier-protein] reductase, NADH-dependent; Equals llo0314. (256 aa)
atpBV-type ATP synthase beta chain (V-type ATPase subunit B); Equals llo0315. (459 aa)
LLO_0316Putative V-type ATP synthase, subunit d; Equals llo0316. (214 aa)
LLO_0317Putative V-type ATP synthase, subunit i; Equals llo0317; Belongs to the V-ATPase 116 kDa subunit family. (616 aa)
LLO_0318Putative V-type ATP synthase, subunit k; Equals llo0318. (146 aa)
LLO_0319Putative V-type ATP synthase, subunit e; Equals llo0319. (234 aa)
atpAV-type ATP synthase alpha chain 1 (V-type ATPase subunit A 1); Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (603 aa)
rpsI30S ribosomal subunit protein S9; Equals llo0346; Belongs to the universal ribosomal protein uS9 family. (143 aa)
petBPutative ubiquinol--cytochrome c reductase, cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (403 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (544 aa)
LLO_0380Putative non-ribosomal peptide synthase (C-terminal part); Equals llo0379b. (154 aa)
sdhCSuccinate dehydrogenase, cytochrome b556 subunit; Equals llo0393. (124 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Equals llo0395; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (589 aa)
sucA2-oxoglutarate dehydrogenase, E1 subunit; Equals llo0397. (934 aa)
sucBDihydrolipoamide succinyltransferase, E2 subunit; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
pdxHPutative pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (215 aa)
fisGlobal DNA-binding transcriptional dual regulator; Equals llo0406; similar to DNA-binding proteins Fis; Belongs to the transcriptional regulatory Fis family. (93 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
LLO_0422Equals llo0422; Predicted membrane protein, similar to putative permease. (359 aa)
LLO_0423Equals llo0423; Putative membrane protein. (356 aa)
LLO_0442Putative ABC transporter, permease protein; Equals llo0442. (386 aa)
indAIndigoidine synthase A-like protein, uncharacterized enzyme involved in pigment biosynthesis; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (301 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (694 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (231 aa)
rplJ50S ribosomal subunit protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (174 aa)
rpoBRNA polymerase B-subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1368 aa)
rpoCRNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1398 aa)
rpsL30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (126 aa)
rpsL-230S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (175 aa)
rplB50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (275 aa)
rpsS30S ribosomal subunit protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplV50S ribosomal subunit protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (111 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (121 aa)
rpsE30S ribosomal subunit protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (169 aa)
rpmD50S ribosomal subunit protein L30; Equals llo0504. (61 aa)
rplO50S ribosomal subunit protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
secYPreprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (444 aa)
rpsD30S ribosomal subunit protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa)
rpoADNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (330 aa)
smpASmall protein A, tmRNA-binding; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (131 aa)
LLO_0546Putative HlyD family secretion protein; Equals llo0546; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (383 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (942 aa)
bioCBiotin synthase BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (285 aa)
xseBPutative exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (72 aa)
gpsAEquals llo0575; similar to glycerol-3-phosphate dehydrogenase (NAD+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (329 aa)
lolEOuter membrane-specific lipoprotein transporter subunit; Equals llo0593; similar to ABC transporter, permease component. (414 aa)
sdhC-2Succinate dehydrogenase, cytochrome b556 subunit; Equals llo0662. (124 aa)
sdhA-2Succinate dehydrogenase flavoprotein subunit; Equals llo0664; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (586 aa)
LLO_0665Putative DNA-3-methyladenine glycosylase; Equals llo0665. (304 aa)
rtcBEquals llo0715; similar to unknown proteins; Belongs to the RtcB family. (476 aa)
LLO_0716Hypothetical protein; Equals llo0716. (109 aa)
LLO_0736Hypothetical protein, weakly similar to eukaryotic protein; Equals llo0736. (576 aa)
thiJPutative 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme; Equals llo0768. (211 aa)
acrARND efflux membrane fusion protein, acriflavin resistance protein E; Equals llo0820; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (423 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (460 aa)
LLO_0843Hypothetical protein; Equals llo0843. (169 aa)
LLO_0871Putative SAM dependent methyltransferase; Equals llo0871. (326 aa)
galUGlucose-1-phosphate uridylyltransferase; Equals llo0885. (291 aa)
recQEquals llo0889; similar to ATP-dependent DNA helicase RecQ. (604 aa)
rpoZRNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (67 aa)
thiSPutative thiamine biosynthesis protein ThiS; Equals llo0922. (66 aa)
LLO_0980Putative ABC transporter, ATP-binding protein; Equals llo0980. (308 aa)
LLO_0981Putative ABC transporter, permease component; Equals llo0981. (377 aa)
fabI-2Equals llo1044; similar to Enoyl-[acyl-carrier-protein] reductase. (262 aa)
uvrDDNA helicase II; Equals llo1055. (721 aa)
mccAEquals llo1074; similar to Acetyl/propionyl-CoA carboxylase, alpha subunit. (654 aa)
LLO_1075Equals llo1075; similar to enoyl-CoA hydratase/isomerase. (271 aa)
LLO_1076Equals llo1076; similar to Acetyl/propionyl-CoA carboxylase, beta subunit. (535 aa)
rnpAPutative ribonuclease P protein component (RNase P); RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (114 aa)
atpB-2Putative H+-transporting ATP synthase chain a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (277 aa)
atpEPutative H+-transporting ATP synthase chain c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (91 aa)
atpFPutative H+-transporting ATP synthase chain b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa)
atpHF1 sector of membrane-bound ATP synthase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (180 aa)
atpA-2F1 sector of membrane-bound ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (517 aa)
atpGPutative H+-transporting ATP synthase chain gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (288 aa)
atpDPutative H+-transporting ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (458 aa)
atpCPutative H+-transporting ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa)
parCDNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (753 aa)
LLO_3401Putative transcriptional regulator, LysR family; Equals llo3401; Belongs to the LysR transcriptional regulatory family. (300 aa)
LLO_3400Equals llo3400; similar to methyltransferase. (213 aa)
LLO_3373Hypothetical protein; Equals llo3373. (293 aa)
LLO_3363Conserved hypothetical protein; Equals llo3363. (404 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (663 aa)
LLO_3344Hypothetical protein; Equals llo3344. (706 aa)
ubiHEquals llo3337; similar to 2-octaprenyl-6-methoxyphenol hydroxylase. (409 aa)
visCPutative oxidoreductase with FAD/NAD(P)-binding domain; Equals llo3336. (390 aa)
LLO_3299Putative methyltransferase involved in chemotaxis (CheR domain); Equals llo3299. (293 aa)
gcsBProbable glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (488 aa)
gcsAProbable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (459 aa)
gcvHPutative glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
LLO_3272Equals llo3272; similar to 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (298 aa)
galU-2Glucose-1-phosphate uridylyltransferase; Equals llo3171. (300 aa)
bexDCapsule polysaccharide export protein bexD precursor; Equals llo3149. (369 aa)
glsAEquals llo3142; similar to glutaminase; Belongs to the glutaminase family. (309 aa)
budBPutative acetolactate synthase; Equals llo3139; Belongs to the TPP enzyme family. (546 aa)
sufBComponent of SufBCD complex; Equals llo3072; similar to ABC transporter, permease component. (482 aa)
sufCComponent of SufBCD complex, ATP-binding component of ABC superfamily; Equals llo3071; similar to ABC transporter ATP-binding protein. (249 aa)
sufDComponent of SufBCD complex; Equals llo3070; similar ABC transporter, permease component. (426 aa)
dfpPutative DNA/pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa)
LLO_3029Hypothetical protein; Equals llo3029. (282 aa)
LLO_3025Putative citrate lyase beta subunit; Equals llo3025; Belongs to the HpcH/HpaI aldolase family. (284 aa)
LLO_2970Hypothetical protein (N-terminal part); Equals llo2969. (254 aa)
traITraI protein; Equals llo2892. (620 aa)
traC-2traD protein; Equals llo2889. (730 aa)
LLO_2869Putative metallophosphoesterase; Equals llo2869. (377 aa)
LLO_2866Putative type I restriction-modification system (methylase_S); Equals llo2866. (466 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (572 aa)
ffhPutative signal recognition particle protein Ffh; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the indivi [...] (459 aa)
yadGEquals llo2822; Highly similar to ATP-binding component of ABC transporter. (304 aa)
yadHPutative transporter subunit: membrane component of ABC superfamily; Equals llo2821; Highly similar to ABC-type multidrug transport system, permease component. (257 aa)
ompRDNA-binding response regulator in two-component regulatory system with EnvZ; Equals llo2778. (242 aa)
LLO_2772Putative transcriptional regulator, LysR family; Equals llo2772; Belongs to the LysR transcriptional regulatory family. (305 aa)
accCBiotin carboxylase (A subunit of acetyl-CoA carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
accBacetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (161 aa)
yhbHEquals llo2710; similar to putative sigma-54 modulation protein. (97 aa)
rpoNRNA polymerase sigma-54 factor (sigma-L); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (465 aa)
yggHtRNA (m7G46) methyltransferase, SAM-dependent; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (224 aa)
yaeTOuter membrane protein assembly factor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (770 aa)
LLO_2674Putative pyridoxamine 5'-phosphate oxidase; Equals llo2674. (207 aa)
LLO_2668Hypothetical protein; Equals llo2667. (543 aa)
LLO_2659Peptidase S24 family protein; Equals llo2659; Belongs to the peptidase S24 family. (168 aa)
uvrCPutative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (620 aa)
holCEquals llo2636; similar to DNA polymerase III, chi subunit. (144 aa)
LLO_2603Equals llo2603; similar to propionyl-CoA carboxylase beta chain. (472 aa)
cydBCytochrome d ubiquinol oxidase subunit II; Equals llo2594. (379 aa)
cydACytochrome d ubiquinol oxidase subunit I; Equals llo2593. (509 aa)
potAPutative spermidine/putrescine transport system ATP-binding protein PotA; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (364 aa)
LLO_2576Hypothetical protein; Equals llo2576. (177 aa)
hslVPeptidase component of the HslUV protease (Heat shock protein); Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (182 aa)
hslUATP-dependent hsl protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (440 aa)
wrbAEquals llo2566; similar to flavoprotein WrbA (Trp repressor binding protein); Belongs to the WrbA family. (201 aa)
mdcCPutative malonate decarboxylase, delta subunit; Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism. (396 aa)
mdcEMalonate decarboxylase gamma-subunit, MdcE; Equals llo2545. (235 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (422 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (690 aa)
carACarbamoyl-phosphate synthetase, glutamine (small subunit); Equals llo2503; Belongs to the CarA family. (370 aa)
hypEHydrogenase expression/formation protein HypE; Equals llo2447. (353 aa)
hypFHydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (741 aa)
hypAHydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
LLO_2373Putative periplasmic binding protein; Equals llo2373. (313 aa)
LLO_2372Putative NAD/NADP octopine/nopaline dehydrogenase; Equals llo2372. (352 aa)
accDPutative acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa)
LLO_2337Putative DNA polymerase III, delta subunit; Equals llo2337. (341 aa)
ycaJRecombination protein; Equals llo2322; conserved hypothetical protein. (431 aa)
LLO_2305Hypothetical protein; Equals llo2304; Belongs to the transcriptional regulatory Fis family. (93 aa)
gatAGlutamyl-tRNA(Gln) amidotransferase (subunit A); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (480 aa)
LLO_2286Putative ABC transporter, permease component; Equals llo2286. (378 aa)
LLO_2284Putative ABC transporter, ATP-binding protein; Equals llo2284. (319 aa)
LLO_2283Hypothetical protein (C-terminal part); Equals llo2282c. (383 aa)
yecSPutative transporter subunit: permease component of ABC superfamily transporter; Equals llo2279; similar to amino acid ABC transporter permease. (212 aa)
ugpEGlycerol-3-phosphate transporter subunit; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. (276 aa)
ugpCGlycerol-3-phosphate transporter subunit; Equals llo2261; similar to sn-glycerol-3-phosphate transport ATP-binding protein; Belongs to the ABC transporter superfamily. (362 aa)
guaBPutative IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
iolDEquals llo2233; similar to malonic semialdehyde oxidative decarboxylase; Belongs to the TPP enzyme family. (623 aa)
LLO_2215Equals llo2215; similar to hypothetical protein. (408 aa)
LLO_2170Hypothetical protein; Equals llo2170. (268 aa)
qxtAEquals llo2120; similar to cytochrome d ubiquinol oxidase subunit I. (456 aa)
LLO_2091Equals llo2091; similar to ABC transporter permease protein. (375 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
LLO_2049Hypothetical protein; Equals llo2049. (109 aa)
xseAExonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (442 aa)
trpGAnthranilate synthase component II; Equals llo2028. (188 aa)
lptBPutative lipopolysaccharide transport protein B: ATP-binding component of ABC superfamily; Equals llo2027; similar to ABC transporter, ATP-binding protein. (241 aa)
yrbEToluene transporter subunit: membrane component of ABC superfamily; Equals llo2021; similar to permease of ABC transporter. (260 aa)
LLO_2017Equals llo2017; similar to conserved hypothetical protein; Belongs to the BolA/IbaG family. (81 aa)
LLO_1987Equals llo1987; similar to UmuD protein; Belongs to the peptidase S24 family. (168 aa)
hbpABacterial extracellular solute-binding protein; Equals llo1932. (719 aa)
LLO_1863Putative SOS (Error prone) mutagenesis protein UmuD; Equals llo1863; Belongs to the peptidase S24 family. (168 aa)
LLO_1831Putative conjugative transfer protein TraI; Equals llo1831. (986 aa)
gyrADNA gyrase, subunit A, type II topoisomerase; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP- [...] (866 aa)
rpsA30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (559 aa)
aceEPyruvate dehydrogenase (decarboxylase component) E1p; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
aceFPyruvate dehydrogenase (dihydrolipoyltransacetylase component) E2p; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (541 aa)
rpsB30S ribosomal protein S2; Equals llo1720; Belongs to the universal ribosomal protein uS2 family. (253 aa)
LLO_1673Equals llo1673; similar to unknown proteins. (110 aa)
LLO_1671Putative amidase; Equals llo1671. (463 aa)
LLO_1667Putative amidase; Equals llo1667. (578 aa)
LLO_1607Putative Naringenin-chalcone synthase; Equals llo1607. (367 aa)
LLO_1573Putative transmembrane protein; Equals llo1573. (635 aa)
LLO_1533Equals llo1533; similar to conserved hypothetical protein. (224 aa)
odpBranched-chain alpha-keto acid dehydrogenase subunit E2; Equals llo1517; pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase). (370 aa)
ruvBPutative Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (338 aa)
glpDGlycerol-3-phosphate dehydrogenase; Equals llo1499; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (507 aa)
LLO_1488Putative DNA polymerase III, delta' subunit; Equals llo1488. (304 aa)
rpmF50S ribosomal subunit protein L32; Equals llo1479; Belongs to the bacterial ribosomal protein bL32 family. (63 aa)
fis-2Global DNA-binding transcriptional dual regulator; Equals llo1460; similar to DNA-binding protein Fis; Belongs to the transcriptional regulatory Fis family. (99 aa)
lspGType II secretory pathway protein LspG; Equals llo1448. (140 aa)
lspHType II secretory pathway protein LspH; Equals llo1447. (165 aa)
lspIType II secretory pathway protein LspI; Equals llo1446. (128 aa)
lspJType II secretory pathway protein LspJ; Equals llo1445. (212 aa)
rir1Putative ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (941 aa)
LLO_1416Putative transcriptional regulator, ArsR family; Equals llo1416. (98 aa)
LLO_1378Putative ABC transporter (permease); Equals llo1378. (252 aa)
ytfHPutative transcriptional regulator; Equals llo1368. (124 aa)
poxBPyruvate dehydrogenase (pyruvate oxidase), thiamin-dependent, FAD-binding; Equals llo1357; Belongs to the TPP enzyme family. (575 aa)
bamDPutative competence lipoprotein comL precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (257 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa)
LLO_1274Putative general secretion pathway protein L; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (378 aa)
LLO_1273Putative general secretion pathway protein; Equals llo1273. (160 aa)
LLO_1263Putative 6,7-dimethyl-8-ribityllumazine synthase (Riboflavinsynthase); Equals llo1263; Belongs to the DMRL synthase family. (142 aa)
LLO_1262Putative 6,7-dimethyl-8-ribityllumazine synthase (Riboflavinsynthase); Equals llo1262; Belongs to the DMRL synthase family. (140 aa)
LLO_1195Putative coiled-coil protein; Equals llo1195. (532 aa)
lspDType II protein secretion LspD; Equals llo1186. (786 aa)
qseBDNA-binding response regulator in two-component regulatory system with QseC; Equals llo1159; similar to two component response regulator. (225 aa)
ruvAHolliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (198 aa)
Your Current Organism:
Legionella longbeachae
NCBI taxonomy Id: 661367
Other names: L. longbeachae NSW150, Legionella longbeachae NSW150, Legionella longbeachae str. NSW150, Legionella longbeachae strain NSW150
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