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tpi tpi yahK yahK pgi pgi pfp pfp odp odp LLO_1518 LLO_1518 odpA odpA LLO_1570 LLO_1570 lpd lpd aceF aceF aceE aceE LLO_1948 LLO_1948 LLO_1949 LLO_1949 ppsA ppsA LLO_2332 LLO_2332 frmA frmA ywdH ywdH eno eno gpmI gpmI LLO_2717 LLO_2717 glk glk gap gap pgk pgk pykA pykA acsB acsB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tpiTriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
yahKPutative oxidoreductase, Zn-dependent and NAD(P)-binding; Equals llo0585. (348 aa)
pgiGlucose-6-phosphate isomerase; Equals llo0884; Belongs to the GPI family. (483 aa)
pfpPutative PPi dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (414 aa)
odpBranched-chain alpha-keto acid dehydrogenase subunit E2; Equals llo1517; pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase). (370 aa)
LLO_1518Equals llo1518; similar to pyruvate dehydrogenase E1 (beta subunit). (324 aa)
odpAPyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (357 aa)
LLO_1570Equals llo1570; similar to alcohol dehydrogenase. (327 aa)
lpdLipoamide dehydrogenase, E3 component is part of three enzyme complexes; Equals llo1759. (479 aa)
aceFPyruvate dehydrogenase (dihydrolipoyltransacetylase component) E2p; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (541 aa)
aceEPyruvate dehydrogenase (decarboxylase component) E1p; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
LLO_1948Equals llo1948; Simiar to 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (322 aa)
LLO_1949Equals llo1949; similar to 2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (602 aa)
ppsAPutative phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa)
LLO_2332Equals llo2332; similar to aldehyde dehydrogenase. (506 aa)
frmAAlcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase; Equals llo2480; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
ywdHPutative aldehyde dehydrogenase ywdH; Equals llo2488; Belongs to the aldehyde dehydrogenase family. (456 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (422 aa)
gpmIPutative phosphoglycerate mutase proteins; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa)
LLO_2717Equals llo2717; similar to fructose-bisphosphate aldolase. (336 aa)
glkEquals llo2804; similar to glucokinase; Belongs to the bacterial glucokinase family. (334 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; Equals llo3262; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa)
pgkPhosphoglycerate kinase; Equals llo3263; Belongs to the phosphoglycerate kinase family. (396 aa)
pykAPyruvate kinase II; Equals llo3264; similar to pyruvate kinase II PykA, glucose stimulated. (472 aa)
acsBPutative acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (626 aa)
Your Current Organism:
Legionella longbeachae
NCBI taxonomy Id: 661367
Other names: L. longbeachae NSW150, Legionella longbeachae NSW150, Legionella longbeachae str. NSW150, Legionella longbeachae strain NSW150
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