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fumC fumC sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB sucA sucA sucB sucB sucC sucC sucD sucD LLO_0452 LLO_0452 sdhB-2 sdhB-2 sdhC-2 sdhC-2 sdhD-2 sdhD-2 sdhA-2 sdhA-2 acnA acnA odp odp LLO_1518 LLO_1518 odpA odpA acnA-2 acnA-2 lpd lpd aceF aceF aceE aceE gltA gltA LLO_1948 LLO_1948 LLO_1949 LLO_1949 icd icd mdh mdh acnA-3 acnA-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
sdhCSuccinate dehydrogenase, cytochrome b556 subunit; Equals llo0393. (124 aa)
sdhDSuccinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Equals llo0395; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (589 aa)
sdhBSuccinate dehydrogenase, iron sulfur protein; Equals llo0396. (240 aa)
sucA2-oxoglutarate dehydrogenase, E1 subunit; Equals llo0397. (934 aa)
sucBDihydrolipoamide succinyltransferase, E2 subunit; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
LLO_0452Putative aconitate hydratase; Equals llo0452. (647 aa)
sdhB-2Succinate dehydrogenase, iron sulfur protein; Equals llo0661. (232 aa)
sdhC-2Succinate dehydrogenase, cytochrome b556 subunit; Equals llo0662. (124 aa)
sdhD-2Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (119 aa)
sdhA-2Succinate dehydrogenase flavoprotein subunit; Equals llo0664; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (586 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (946 aa)
odpBranched-chain alpha-keto acid dehydrogenase subunit E2; Equals llo1517; pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase). (370 aa)
LLO_1518Equals llo1518; similar to pyruvate dehydrogenase E1 (beta subunit). (324 aa)
odpAPyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (357 aa)
acnA-2Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
lpdLipoamide dehydrogenase, E3 component is part of three enzyme complexes; Equals llo1759. (479 aa)
aceFPyruvate dehydrogenase (dihydrolipoyltransacetylase component) E2p; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (541 aa)
aceEPyruvate dehydrogenase (decarboxylase component) E1p; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
gltACitrate synthase; Equals llo1803; Belongs to the citrate synthase family. (423 aa)
LLO_1948Equals llo1948; Simiar to 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (322 aa)
LLO_1949Equals llo1949; similar to 2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (602 aa)
icdIsocitrate dehydrogenase; Equals llo2043. (418 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
acnA-3Putative transposase (C-terminal part); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (946 aa)
Your Current Organism:
Legionella longbeachae
NCBI taxonomy Id: 661367
Other names: L. longbeachae NSW150, Legionella longbeachae NSW150, Legionella longbeachae str. NSW150, Legionella longbeachae strain NSW150
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