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| | coq7 | Putative ubiquinone biosynthesis protein; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. (213 aa) |
| | argD | Equals llo0059; similar to ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (389 aa) |
| | cysK | Hypothetical protein (C-terminal part); Equals llo0075b. (316 aa) |
| | fumC | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa) |
| | ubiD | Equals llo0084; Highly similar to 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; Belongs to the UbiD family. (489 aa) |
| | panD | Putative aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (133 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (250 aa) |
| | asg | Equals llo0188; similar to L-asparaginase I. (336 aa) |
| | cpsB | Equals llo0199; Highly similar to mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 2 family. (474 aa) |
| | LLO_0205 | Equals llo0205; similar to guanosine monophosphate reductase GuaC. (336 aa) |
| | ribE | Riboflavin synthase alpha chain; Equals llo0215. (204 aa) |
| | LLO_0235 | Putative dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (292 aa) |
| | fni | Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (341 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (264 aa) |
| | tpi | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase, NADH-dependent; Equals llo0314. (256 aa) |
| | hemX | Uroporphyrinogen III methylase HemX; Equals llo0323. (376 aa) |
| | hemD | Uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (252 aa) |
| | hemC | Porphobilinogen deaminase HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa) |
| | miaA | Putative tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (314 aa) |
| | panC | Putative pantothenate synthetases; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (253 aa) |
| | panB | Putative 3-methyl-2-oxobutanoatehydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (262 aa) |
| | sdhC | Succinate dehydrogenase, cytochrome b556 subunit; Equals llo0393. (124 aa) |
| | sdhD | Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit; Equals llo0395; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (589 aa) |
| | sdhB | Succinate dehydrogenase, iron sulfur protein; Equals llo0396. (240 aa) |
| | sucA | 2-oxoglutarate dehydrogenase, E1 subunit; Equals llo0397. (934 aa) |
| | sucB | Dihydrolipoamide succinyltransferase, E2 subunit; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa) |
| | sucC | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | plsC | Equals llo0414; similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase. (243 aa) |
| | LLO_0452 | Putative aconitate hydratase; Equals llo0452. (647 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (276 aa) |
| | hemA | Glutamyl tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (424 aa) |
| | ispA | Geranyltranstransferase; Equals llo0566; similar to geranyltranstransferase; farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. (293 aa) |
| | gpsA | Equals llo0575; similar to glycerol-3-phosphate dehydrogenase (NAD+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (329 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (352 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa) |
| | yahK | Putative oxidoreductase, Zn-dependent and NAD(P)-binding; Equals llo0585. (348 aa) |
| | LLO_0589 | Equals llo0589; similar to phosphatase. (220 aa) |
| | LLO_0604 | Equals llo0604; similar to leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (357 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Equals llo0610; Belongs to the ribulose-phosphate 3-epimerase family. (217 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa) |
| | LLO_0636 | 2-oxoisovalerate dehydrogenase E1 component; Equals llo0636; similar to pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (745 aa) |
| | gcdH | Equals llo0637; similar to glutaryl-CoA dehydrogenase. (385 aa) |
| | sdhB-2 | Succinate dehydrogenase, iron sulfur protein; Equals llo0661. (232 aa) |
| | sdhC-2 | Succinate dehydrogenase, cytochrome b556 subunit; Equals llo0662. (124 aa) |
| | sdhD-2 | Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (119 aa) |
| | sdhA-2 | Succinate dehydrogenase flavoprotein subunit; Equals llo0664; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (586 aa) |
| | acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (946 aa) |
| | asnA | Asparagine synthetase A; Equals llo0686. (325 aa) |
| | LLO_0726 | Putative D-isomer specific 2-hydroxyacid dehydrogenase; Equals llo0726; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (399 aa) |
| | LLO_0727 | Putative phosphoserine phosphatase; Equals llo0727. (264 aa) |
| | glyA | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | metB | Equals llo0841; similar to cystathionine beta-lyase. (384 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (367 aa) |
| | proC | Putative pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (276 aa) |
| | pgi | Glucose-6-phosphate isomerase; Equals llo0884; Belongs to the GPI family. (483 aa) |
| | galU | Glucose-1-phosphate uridylyltransferase; Equals llo0885. (291 aa) |
| | ydiI | Putative esterase; Equals llo1027. (142 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (357 aa) |
| | ribA | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (402 aa) |
| | fabI-2 | Equals llo1044; similar to Enoyl-[acyl-carrier-protein] reductase. (262 aa) |
| | mvaB | Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase); Equals llo1073; similar to hydroxymethylglutaryl-CoA lyase. (302 aa) |
| | atoB | Equals llo1078; similar to acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | lysAC | Equals llo1101; similar to diaminopimelate decarboxylase, aspartate kinase (fusion of lysA and lysC); Belongs to the Orn/Lys/Arg decarboxylase class-II family. (853 aa) |
| | hemB | Equals llo1105; similar to delta-aminolevulinic acid dehydratases (porphobilinogen synthase); Belongs to the ALAD family. (331 aa) |
| | surE | Acid phosphatase SurE (Stationary phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Equals llo1172; Belongs to the TrpF family. (207 aa) |
| | trpB | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | pfp | Putative PPi dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (414 aa) |
| | gltX | Glutamyl-tRNA synthetase, catalytic subunit; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (471 aa) |
| | LLO_1262 | Putative 6,7-dimethyl-8-ribityllumazine synthase (Riboflavinsynthase); Equals llo1262; Belongs to the DMRL synthase family. (140 aa) |
| | LLO_1263 | Putative 6,7-dimethyl-8-ribityllumazine synthase (Riboflavinsynthase); Equals llo1263; Belongs to the DMRL synthase family. (142 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase (PRA-CH) / phosphoribosyl-ATP pyrophosphatase (PRA-PH); Equals llo1297; In the N-terminal section; belongs to the PRA-CH family. (207 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF (IGP synthase cyclase subunit); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Equals llo1299. (246 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa) |
| | hisB | Histidinol-phosphatase/imisazoleglycerol- phosphate dehydratase; Equals llo1301; In the N-terminal section; belongs to the histidinol- phosphatase family. (352 aa) |
| | hisC | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); Equals llo1302. (358 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | hisG | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (293 aa) |
| | hemF | Oxygen-dependent coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (314 aa) |
| | DWF | 7-dehydrocholesterol reductase (7-DHC reductase) (Sterol Delta(7)-reductase) (Protein DWARF 5); Equals llo1320. (432 aa) |
| | aspB | Equals llo1324; similar to aspartate aminotransferase. (386 aa) |
| | LLO_1325 | Equals llo1325; similar to chorismate mutase (C-terminal part). (87 aa) |
| | LLO_1326 | Equals llo1326; similar to chorismate mutase (N-terminal part). (193 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa) |
| | hisC-2 | Equals llo1342; similar to histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (369 aa) |
| | katA | Catalase; Equals llo1355; Belongs to the catalase family. (486 aa) |
| | LLO_1420 | Putative 2-hydroxyacid dehydrogenase, D-isomer specific; Equals llo1420; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (342 aa) |
| | fabD-2 | Malonyl CoA-acyl carrier protein transacylase; Equals llo1482. (312 aa) |
| | fabG-3 | 3-oxoacyl-[acyl-carrier protein] reductase (3-ketoacyl-acyl carrier protein reductase); Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | acp | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (82 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (222 aa) |
| | glpD | Glycerol-3-phosphate dehydrogenase; Equals llo1499; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (507 aa) |
| | odp | Branched-chain alpha-keto acid dehydrogenase subunit E2; Equals llo1517; pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase). (370 aa) |
| | LLO_1518 | Equals llo1518; similar to pyruvate dehydrogenase E1 (beta subunit). (324 aa) |
| | odpA | Pyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (357 aa) |
| | ndk | Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | LLO_1550 | Equals llo1550; similar to conserved hypothetical protein. (142 aa) |
| | hemL | Equals llo1552; similar to glutamate-1-semialdehyde-2,1-aminomutase. (428 aa) |
| | LLO_1562 | Putative ribose/galactose isomerase; Equals llo1562. (147 aa) |
| | LLO_1570 | Equals llo1570; similar to alcohol dehydrogenase. (327 aa) |
| | LLO_1593 | Putative pyrimidine phosphoribosyl transferase; Equals llo1593. (186 aa) |
| | LLO_1614 | Putative serine hydroxymethyltransferase; Equals llo1614. (450 aa) |
| | LLO_1636 | Putative shikimate kinase; Equals llo1636. (255 aa) |
| | acnA-2 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa) |
| | putA | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1048 aa) |
| | ubiG | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (231 aa) |
| | lpd | Lipoamide dehydrogenase, E3 component is part of three enzyme complexes; Equals llo1759. (479 aa) |
| | aceF | Pyruvate dehydrogenase (dihydrolipoyltransacetylase component) E2p; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (541 aa) |
| | aceE | Pyruvate dehydrogenase (decarboxylase component) E1p; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | xapA | Putative xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (279 aa) |
| | ubiA | Putative 4-hydroxybenzoate-octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (280 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (439 aa) |
| | serC | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa) |
| | gltA | Citrate synthase; Equals llo1803; Belongs to the citrate synthase family. (423 aa) |
| | lidK | Putative phosphatidylcholine synthase; Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (253 aa) |
| | yfcX | Enoyl CoA hydratase; Equals llo1816; similar to alpha subunit of fatty-acid oxidation complex, 3-hydroxyacyl-CoA dehydrogenase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (672 aa) |
| | yfcY | beta-ketoacyl-CoA thiolase, anaerobic, subunit; Equals llo1817; similar to beta-Subunit of fatty acid oxidation complex, 3-keto-acyl-CoA-thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (439 aa) |
| | LLO_1878 | Putative asparagine synthase, glutamine-hydrolyzing protein; Equals llo1878. (594 aa) |
| | LLO_1948 | Equals llo1948; Simiar to 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (322 aa) |
| | LLO_1949 | Equals llo1949; similar to 2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (602 aa) |
| | ribF | Riboflavin biosynthesis protein RibF (Riboflavin kinase/FMN adenylyltransferase); Equals llo1960; Belongs to the ribF family. (322 aa) |
| | trpG | Anthranilate synthase component II; Equals llo2028. (188 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa) |
| | trpC | Indole-3-glycerol phosphate synthases; Equals llo2030; Belongs to the TrpC family. (259 aa) |
| | icd | Isocitrate dehydrogenase; Equals llo2043. (418 aa) |
| | ppsA | Putative phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | purB | Adenylosuccinate lyase; Equals llo2055; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | sdhL | Equals llo2065; Putative L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | accA | acetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | LLO_2084 | Equals llo2084; similar to mevalonate kinase. (293 aa) |
| | LLO_2085 | Equals llo2085; similar to diphosphomevalonate decarboxylase. (316 aa) |
| | mvaA | Hydroxymethylglutaryl CoA reductase; Equals llo2093; similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (432 aa) |
| | LLO_2199 | Putative ribose-phosphate pyrophosphokinase; Equals llo2199; Belongs to the ribose-phosphate pyrophosphokinase family. (298 aa) |
| | iolG | Equals llo2235; similar to myo-inositol 2-dehydrogenase. (338 aa) |
| | guaB | Putative IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa) |
| | trpE | Anthranilate synthase; Equals llo2266. (713 aa) |
| | argH | Argininosuccinate lyase; Equals llo2276. (410 aa) |
| | argG | Argininosuccinate synthase; Equals llo2277; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa) |
| | suhB | Equals llo2306; similar to inositol-1-monophosphatase. (261 aa) |
| | fadA | Equals llo2330; similar to 3-ketoacyl-CoA thiolase (thiolase I, acetyl-CoA transferase); Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | LLO_2332 | Equals llo2332; similar to aldehyde dehydrogenase. (506 aa) |
| | accD | Putative acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa) |
| | LLO_2358 | Putative D-3-phosphoglycerate dehydrogenase (N-terminal part); Equals llo2357a. (450 aa) |
| | LLO_2367 | HAD-superfamily hydrolase; Equals llo2367. (213 aa) |
| | LLO_2375 | Putative cysteine synthase; Equals llo2375. (333 aa) |
| | LLO_2402 | Equals llo2402; similar to acetylornithine deacetylase. (386 aa) |
| | frmA | Alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase; Equals llo2480; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa) |
| | ywdH | Putative aldehyde dehydrogenase ywdH; Equals llo2488; Belongs to the aldehyde dehydrogenase family. (456 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (382 aa) |
| | LLO_2507 | Equals llo2507; similar to 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase. (444 aa) |
| | hemE | Putative transposase (fragment); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (351 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (422 aa) |
| | iaaA | Transposase (fragment); Equals to LEGLO_2806; Gene remnant; enzyme. (303 aa) |
| | wrbA | Equals llo2566; similar to flavoprotein WrbA (Trp repressor binding protein); Belongs to the WrbA family. (201 aa) |
| | fabG-4 | Equals llo2608; similar to 3-oxoacyl-[acyl-carrier protein] reductase. (251 aa) |
| | LLO_2612 | Equals llo2612; similar to acyl-carrier protein. (75 aa) |
| | ispB | Equals llo2666; similar to octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. (322 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Equals llo2690; Belongs to the CDS family. (260 aa) |
| | uppS | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (252 aa) |
| | gpmI | Putative phosphoglycerate mutase proteins; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa) |
| | pssA | Equals llo2713; similar to CDP-diacylglycerol-serine O-phosphatidyltransferase (Phosphatidylserine synthase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (245 aa) |
| | LLO_2717 | Equals llo2717; similar to fructose-bisphosphate aldolase. (336 aa) |
| | aroQ | 3-dehydroquinate dehydratase type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | accB | acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (161 aa) |
| | accC | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa) |
| | purH | Equals llo2727; similar to phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase (bifunctionnal). (529 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (345 aa) |
| | glk | Equals llo2804; similar to glucokinase; Belongs to the bacterial glucokinase family. (334 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (230 aa) |
| | zwf | Putative Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa) |
| | cyoE | Putative Polyprenyltransferase (cytochrome oxidase assembly factor); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (295 aa) |
| | LLO_2814 | Equals llo2814; similar to conserved hypothetical proteins, hypothetical cytochrome oxidase assembly protein. (334 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa) |
| | plsY | Putative membrane protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (281 aa) |
| | acnA-3 | Putative transposase (C-terminal part); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (946 aa) |
| | gadB | Glutamate decarboxylase B, PLP-dependent; Equals llo2994; Belongs to the group II decarboxylase family. (464 aa) |
| | argF | Ornithine carbamoyltransferase; Equals llo3018. (356 aa) |
| | dgkA | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (121 aa) |
| | algC | Phosphomannomutase; Equals llo3061. (462 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (194 aa) |
| | FrgA | Siderophore biosynthetic enzyme FrgA; Equals llo3129. (576 aa) |
| | budB | Putative acetolactate synthase; Equals llo3139; Belongs to the TPP enzyme family. (546 aa) |
| | cpsB-2 | Mannose-1-phosphate guanyltransferase; Equals llo3148; Belongs to the mannose-6-phosphate isomerase type 2 family. (491 aa) |
| | LLO_3163 | Putative D-isomer specific 2-hydroxyacid dehydrogenase; Equals llo3163; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (311 aa) |
| | galU-2 | Glucose-1-phosphate uridylyltransferase; Equals llo3171. (300 aa) |
| | LLO_3181 | Putative alpha/beta hydrolase; Equals llo3181. (367 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (355 aa) |
| | proA-2 | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa) |
| | LLO_3211 | Putative asparagine synthetase, glutamine-hydrolyzing; Equals llo3211. (594 aa) |
| | LLO_3253 | Protein containing FG-GAP repeats (motif found in alpha integrins); Equals llo3253. (539 aa) |
| | tkt | Putative transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa) |
| | gap | Glyceraldehyde 3-phosphate dehydrogenase; Equals llo3262; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa) |
| | pgk | Phosphoglycerate kinase; Equals llo3263; Belongs to the phosphoglycerate kinase family. (396 aa) |
| | pykA | Pyruvate kinase II; Equals llo3264; similar to pyruvate kinase II PykA, glucose stimulated. (472 aa) |
| | dapB | Putative dihydrodipicolinate reductase proteins; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (243 aa) |
| | acsB | Putative acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (626 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II (FGAM synthase II); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is [...] (778 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo ligase; Equals llo3275. (347 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (FGAM synthase I); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (433 aa) |
| | purC | Phosphoribosylamidoimidazole-succinocarboxamide synthase; Equals llo3277; Belongs to the SAICAR synthetase family. (329 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (502 aa) |
| | purD | Phosphoribosylamine-glycine ligase; Equals llo3279; Belongs to the GARS family. (438 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (192 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa) |
| | gcvT | Putative glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (360 aa) |
| | gcvH | Putative glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | gcsA | Probable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (459 aa) |
| | gcsB | Probable glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (488 aa) |
| | rpiA | Ribose 5-phosphate isomerase, constitutive; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (216 aa) |
| | visC | Putative oxidoreductase with FAD/NAD(P)-binding domain; Equals llo3336. (390 aa) |
| | ubiH | Equals llo3337; similar to 2-octaprenyl-6-methoxyphenol hydroxylase. (409 aa) |
| | hss | Homospermidine synthase; Equals llo3342. (466 aa) |
| | ispB-2 | Putative octaprenyl-diphosphate synthase; Equals llo3345; Belongs to the FPP/GGPP synthase family. (322 aa) |
| | LLO_3348 | Equals llo3348; similar to aspartate aminotransferase. (392 aa) |
| | LLO_3400 | Equals llo3400; similar to methyltransferase. (213 aa) |
| | LLO_3403 | Equals llo3403; similar to ornithine cyclodeaminase. (323 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (285 aa) |
| | treF | Alpha,alpha-trehalase; Equals llo3440. (512 aa) |
