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| | argD | Equals llo0059; similar to ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (389 aa) |
| | cysK | Hypothetical protein (C-terminal part); Equals llo0075b. (316 aa) |
| | fumC | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa) |
| | tpi | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa) |
| | hemX | Uroporphyrinogen III methylase HemX; Equals llo0323. (376 aa) |
| | hemD | Uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (252 aa) |
| | hemC | Porphobilinogen deaminase HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa) |
| | LLO_0366 | Putative 4-hydroxy-2-oxovalerate aldolase; Equals llo0366. (284 aa) |
| | sdhC | Succinate dehydrogenase, cytochrome b556 subunit; Equals llo0393. (124 aa) |
| | sdhD | Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit; Equals llo0395; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (589 aa) |
| | sdhB | Succinate dehydrogenase, iron sulfur protein; Equals llo0396. (240 aa) |
| | sucA | 2-oxoglutarate dehydrogenase, E1 subunit; Equals llo0397. (934 aa) |
| | sucB | Dihydrolipoamide succinyltransferase, E2 subunit; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa) |
| | sucC | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa) |
| | pdxH | Putative pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (215 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | fabG | Equals llo0418; similar to acetoacetyl-CoA reductase. (246 aa) |
| | fabG-2 | Equals llo0419; similar to acetoacetyl-CoA reductase. (248 aa) |
| | LLO_0452 | Putative aconitate hydratase; Equals llo0452. (647 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (276 aa) |
| | hemA | Glutamyl tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (424 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa) |
| | yahK | Putative oxidoreductase, Zn-dependent and NAD(P)-binding; Equals llo0585. (348 aa) |
| | LLO_0600 | GGDEF domain protein (C-terminal part); Equals llo0599. (210 aa) |
| | LLO_0601 | Equals llo0601; similar to unknown protein. (329 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Equals llo0610; Belongs to the ribulose-phosphate 3-epimerase family. (217 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa) |
| | gcdH | Equals llo0637; similar to glutaryl-CoA dehydrogenase. (385 aa) |
| | sdhB-2 | Succinate dehydrogenase, iron sulfur protein; Equals llo0661. (232 aa) |
| | sdhC-2 | Succinate dehydrogenase, cytochrome b556 subunit; Equals llo0662. (124 aa) |
| | sdhD-2 | Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (119 aa) |
| | sdhA-2 | Succinate dehydrogenase flavoprotein subunit; Equals llo0664; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (586 aa) |
| | acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (946 aa) |
| | LLO_0726 | Putative D-isomer specific 2-hydroxyacid dehydrogenase; Equals llo0726; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (399 aa) |
| | LLO_0727 | Putative phosphoserine phosphatase; Equals llo0727. (264 aa) |
| | LLO_0794 | Equals llo0794; similar to C-terminal part of conserved hypothetical protein. (1120 aa) |
| | glyA | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (389 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Equals llo0840; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | pgi | Glucose-6-phosphate isomerase; Equals llo0884; Belongs to the GPI family. (483 aa) |
| | yccX | Acylphosphatase; Equals llo1028. (91 aa) |
| | atoB | Equals llo1078; similar to acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | lysAC | Equals llo1101; similar to diaminopimelate decarboxylase, aspartate kinase (fusion of lysA and lysC); Belongs to the Orn/Lys/Arg decarboxylase class-II family. (853 aa) |
| | hemB | Equals llo1105; similar to delta-aminolevulinic acid dehydratases (porphobilinogen synthase); Belongs to the ALAD family. (331 aa) |
| | LLO_1111 | Equals llo1111; similar to glutamine synthase; Belongs to the glutamine synthetase family. (456 aa) |
| | hmgA | Homogentisate 1,2-dioxygenase; Equals llo1153. (418 aa) |
| | FolD | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | pfp | Putative PPi dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (414 aa) |
| | gltX | Glutamyl-tRNA synthetase, catalytic subunit; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (471 aa) |
| | LLO_1318 | Putative polysaccharide deacetylase; Equals llo1318. (292 aa) |
| | LLO_1387 | Equals llo1387; similar to nitric oxide reductase. (771 aa) |
| | LLO_1420 | Putative 2-hydroxyacid dehydrogenase, D-isomer specific; Equals llo1420; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa) |
| | glnA | Glutamine synthetase; Equals llo1450; Belongs to the glutamine synthetase family. (469 aa) |
| | odp | Branched-chain alpha-keto acid dehydrogenase subunit E2; Equals llo1517; pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase). (370 aa) |
| | LLO_1518 | Equals llo1518; similar to pyruvate dehydrogenase E1 (beta subunit). (324 aa) |
| | odpA | Pyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (357 aa) |
| | hemL | Equals llo1552; similar to glutamate-1-semialdehyde-2,1-aminomutase. (428 aa) |
| | LLO_1562 | Putative ribose/galactose isomerase; Equals llo1562. (147 aa) |
| | LLO_1570 | Equals llo1570; similar to alcohol dehydrogenase. (327 aa) |
| | LLO_1586 | Haloacid dehalogenase-like hydrolase; Equals llo1586. (251 aa) |
| | LLO_1614 | Putative serine hydroxymethyltransferase; Equals llo1614. (450 aa) |
| | LLO_1657 | Putative short-chain dehydrogenases/reductases family protein; Equals llo1657. (251 aa) |
| | LLO_1667 | Putative amidase; Equals llo1667. (578 aa) |
| | LLO_1668 | Putative NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (394 aa) |
| | LLO_1671 | Putative amidase; Equals llo1671. (463 aa) |
| | acnA-2 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa) |
| | lpd | Lipoamide dehydrogenase, E3 component is part of three enzyme complexes; Equals llo1759. (479 aa) |
| | aceF | Pyruvate dehydrogenase (dihydrolipoyltransacetylase component) E2p; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (541 aa) |
| | aceE | Pyruvate dehydrogenase (decarboxylase component) E1p; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | serC | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa) |
| | gltA | Citrate synthase; Equals llo1803; Belongs to the citrate synthase family. (423 aa) |
| | LLO_1804 | Equals llo1804; weakly similar to NADP-specific glutamate dehydrogenase. (1625 aa) |
| | yneI | Equals llo1805; similar to aldehyde dehydrogenase. (457 aa) |
| | yfcX | Enoyl CoA hydratase; Equals llo1816; similar to alpha subunit of fatty-acid oxidation complex, 3-hydroxyacyl-CoA dehydrogenase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (672 aa) |
| | yfcY | beta-ketoacyl-CoA thiolase, anaerobic, subunit; Equals llo1817; similar to beta-Subunit of fatty acid oxidation complex, 3-keto-acyl-CoA-thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (439 aa) |
| | LLO_1948 | Equals llo1948; Simiar to 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (322 aa) |
| | LLO_1949 | Equals llo1949; similar to 2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (602 aa) |
| | LLO_1954 | Coiled coil protein, some similarities with LidA; Equals llo1954. (588 aa) |
| | LLO_1955 | Equals llo1955; similar to keto-hydroxyglutarate aldolase. (185 aa) |
| | icd | Isocitrate dehydrogenase; Equals llo2043. (418 aa) |
| | ppsA | Putative phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | accA | acetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | nemA | N-ethylmaleimide reductase, FMN-linked; Equals llo2142; similar to NADH-dependent flavin oxidoreductase (Oye family). (351 aa) |
| | LLO_2199 | Putative ribose-phosphate pyrophosphokinase; Equals llo2199; Belongs to the ribose-phosphate pyrophosphokinase family. (298 aa) |
| | iolE | Equals llo2232; similar to myo-inositol catabolism protein iolE. (294 aa) |
| | iolD | Equals llo2233; similar to malonic semialdehyde oxidative decarboxylase; Belongs to the TPP enzyme family. (623 aa) |
| | iolCB | Equals llo2234; Bifuncional protein similar to IolC (sugar kinase) and IolB. (627 aa) |
| | iolG | Equals llo2235; similar to myo-inositol 2-dehydrogenase. (338 aa) |
| | dehII | Haloacid dehalogenase, type II; Equals llo2271. (256 aa) |
| | fadA | Equals llo2330; similar to 3-ketoacyl-CoA thiolase (thiolase I, acetyl-CoA transferase); Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | fadB | Equals llo2331; similar to 3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (788 aa) |
| | LLO_2332 | Equals llo2332; similar to aldehyde dehydrogenase. (506 aa) |
| | accD | Putative acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa) |
| | ackA | Acetate kinase (Acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (391 aa) |
| | LLO_2361 | Putative phosphate acetyl/butaryl transferase; Equals llo2361. (465 aa) |
| | LLO_2418 | Putative alpha/beta superfamily hydrolase; Equals llo2418. (266 aa) |
| | frmC | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa) |
| | frmA | Alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase; Equals llo2480; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa) |
| | ywdH | Putative aldehyde dehydrogenase ywdH; Equals llo2488; Belongs to the aldehyde dehydrogenase family. (456 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (422 aa) |
| | LLO_2561 | Equals llo2561; similar to NADP-dependent malic enzyme. (407 aa) |
| | LLO_2674 | Putative pyridoxamine 5'-phosphate oxidase; Equals llo2674. (207 aa) |
| | gpmI | Putative phosphoglycerate mutase proteins; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa) |
| | LLO_2717 | Equals llo2717; similar to fructose-bisphosphate aldolase. (336 aa) |
| | accB | acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (161 aa) |
| | accC | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa) |
| | eda | Equals llo2803; similar to 2-deydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase. (217 aa) |
| | glk | Equals llo2804; similar to glucokinase; Belongs to the bacterial glucokinase family. (334 aa) |
| | edd | Putative 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (611 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (230 aa) |
| | zwf | Putative Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa) |
| | acnA-3 | Putative transposase (C-terminal part); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (946 aa) |
| | capP | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (771 aa) |
| | gadB | Glutamate decarboxylase B, PLP-dependent; Equals llo2994; Belongs to the group II decarboxylase family. (464 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (194 aa) |
| | LLO_3163 | Putative D-isomer specific 2-hydroxyacid dehydrogenase; Equals llo3163; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (311 aa) |
| | tkt | Putative transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa) |
| | gap | Glyceraldehyde 3-phosphate dehydrogenase; Equals llo3262; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa) |
| | pgk | Phosphoglycerate kinase; Equals llo3263; Belongs to the phosphoglycerate kinase family. (396 aa) |
| | pykA | Pyruvate kinase II; Equals llo3264; similar to pyruvate kinase II PykA, glucose stimulated. (472 aa) |
| | dapB | Putative dihydrodipicolinate reductase proteins; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (243 aa) |
| | acsB | Putative acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (626 aa) |
| | rpiA | Ribose 5-phosphate isomerase, constitutive; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (216 aa) |
