(48 nodes) p53-Independent DNA Damage Response network (Papilio xuthus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	RR46_00619	26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (402 aa)
	RR46_08129	26S protease regulatory subunit rpt1; Belongs to the AAA ATPase family. (434 aa)
	RR46_07566	26S proteasome non-ATPase regulatory subunit 9. (294 aa)
	RR46_07556	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (245 aa)
	RR46_12934	Putative 26S proteasome non-ATPase regulatory subunit 3. (495 aa)
	RR46_02538	M-phase inducer phosphatase. (652 aa)
	RR46_02415	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (269 aa)
	RR46_05055	Serine/threonine-protein kinase grp. (115 aa)
	RR46_13154	26S proteasome non-ATPase regulatory subunit 7. (327 aa)
	RR46_13581	Proteasome activator complex subunit 4. (142 aa)
	RR46_04514	Ovarian-specific serine/threonine-protein kinase Lok. (536 aa)
	RR46_13301	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (428 aa)
	RR46_10833	Proteasome subunit beta type-6. (225 aa)
	RR46_13796	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (255 aa)
	RR46_11312	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (925 aa)
	RR46_12362	26S proteasome non-ATPase regulatory subunit 13. (385 aa)
	RR46_05056	Serine/threonine-protein kinase Chk1. (482 aa)
	RR46_12094	Proteasome inhibitor PI31 subunit. (282 aa)
	RR46_12585	Proteasome subunit beta; Belongs to the peptidase T1B family. (262 aa)
	RR46_02708	Proteasome subunit beta. (205 aa)
	RR46_05609	26S proteasome non-ATPase regulatory subunit 14. (311 aa)
	RR46_03221	26S proteasome non-ATPase regulatory subunit rpn12. (268 aa)
	RR46_06188	UPF0459 protein CG10681. (222 aa)
	RR46_07934	Proteasome subunit beta. (283 aa)
	RR46_04328	26S proteasome non-ATPase regulatory subunit 5. (736 aa)
	RR46_02241	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (474 aa)
	RR46_09449	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (295 aa)
	RR46_13910	Ubiquitin-60S ribosomal protein L40. (129 aa)
	RR46_05949	Proteasome subunit beta. (281 aa)
	RR46_12943	26S proteasome non-ATPase regulatory subunit rpn7. (382 aa)
	RR46_05907	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	RR46_06134	26S proteasome non-ATPase regulatory subunit 11. (420 aa)
	RR46_07433	Proteasome activator complex subunit 3. (246 aa)
	RR46_12836	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (389 aa)
	RR46_13775	Proteasome subunit beta. (205 aa)
	RR46_13580	Proteasome activator complex subunit 4. (1783 aa)
	RR46_13749	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (415 aa)
	RR46_13473	26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (462 aa)
	RR46_14435	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1000 aa)
	RR46_00186	Uncharacterized protein. (211 aa)
	RR46_00763	Proteasome activator complex subunit 4. (77 aa)
	RR46_12008	Gamma-glutamylcyclotransferase. (185 aa)
	RR46_03469	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
	RR46_10008	26S proteasome non-ATPase regulatory subunit 10. (222 aa)
	RR46_08066	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (234 aa)
	RR46_09825	26S proteasome non-ATPase regulatory subunit 4. (367 aa)
	RR46_10002	26S proteasome non-ATPase regulatory subunit 12. (442 aa)
	RR46_06256	Proteasome subunit beta. (233 aa)

Your Current Organism:

Papilio xuthus

NCBI taxonomy Id: 66420
Other names: Asian swallowtail, Chinese swallowtail, Chinese yellow swallowtail, P. xuthus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RR46_00186	RR46_00619	A0A0N1IK91	I4DJY4	Uncharacterized protein.	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	0.584
RR46_00186	RR46_03221	A0A0N1IK91	I4DKA5	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit rpn12.	0.598
RR46_00186	RR46_04514	A0A0N1IK91	A0A194PLY2	Uncharacterized protein.	Ovarian-specific serine/threonine-protein kinase Lok.	0.947
RR46_00186	RR46_05055	A0A0N1IK91	A0A194Q0J0	Uncharacterized protein.	Serine/threonine-protein kinase grp.	0.966
RR46_00186	RR46_05056	A0A0N1IK91	A0A194PU41	Uncharacterized protein.	Serine/threonine-protein kinase Chk1.	0.966
RR46_00186	RR46_07433	A0A0N1IK91	A0A194PWD2	Uncharacterized protein.	Proteasome activator complex subunit 3.	0.626
RR46_00186	RR46_12008	A0A0N1IK91	I4DNI1	Uncharacterized protein.	Gamma-glutamylcyclotransferase.	0.597
RR46_00186	RR46_12943	A0A0N1IK91	I4DJH3	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit rpn7.	0.590
RR46_00186	RR46_13473	A0A0N1IK91	A0A194PG29	Uncharacterized protein.	26S protease regulatory subunit 4; Belongs to the AAA ATPase family.	0.573
RR46_00619	RR46_00186	I4DJY4	A0A0N1IK91	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.584
RR46_00619	RR46_00763	I4DJY4	A0A0N1IAS3	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	Proteasome activator complex subunit 4.	0.756
RR46_00619	RR46_02241	I4DJY4	A0A194QK15	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	Proteasome endopeptidase complex; Belongs to the peptidase T1A family.	0.999
RR46_00619	RR46_02415	I4DJY4	A0A194Q2V7	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.999
RR46_00619	RR46_02538	I4DJY4	A0A194Q3P0	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	M-phase inducer phosphatase.	0.584
RR46_00619	RR46_02708	I4DJY4	A0A194Q5N8	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.992
RR46_00619	RR46_03221	I4DJY4	I4DKA5	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	26S proteasome non-ATPase regulatory subunit rpn12.	0.998
RR46_00619	RR46_03469	I4DJY4	I4DKX7	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.999
RR46_00619	RR46_04328	I4DJY4	A0A194QJT6	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	26S proteasome non-ATPase regulatory subunit 5.	0.993
RR46_00619	RR46_05609	I4DJY4	I4DKB2	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	26S proteasome non-ATPase regulatory subunit 14.	0.999
RR46_00619	RR46_05907	I4DJY4	I4DJQ9	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.990