STRINGSTRING
metL metL argE argE argB argB argG argG argH argH argR argR argI argI pheC pheC serA serA argA argA tyrA tyrA pheA pheA aroL aroL asnB asnB ybiB ybiB ybiK ybiK serC serC aroA aroA aspC aspC argC argC trpE trpE trpG trpG trpD trpD trpC trpC trpB trpB trpA trpA ansA ansA pabB pabB sdaA sdaA yeeZ yeeZ hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI yeaK yeaK aroQ5 aroQ5 aat3 aat3 aroC aroC dapA dapA dapD dapD dapB dapB thrC thrC thrB thrB thrA thrA serB serB aspA aspA asnB2 asnB2 lysC lysC aroE aroE argD argD pabA pabA aroB aroB aroK aroK asd asd yhhY yhhY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
metLBifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. (811 aa)
argEAcetylornithine deacetylase (Acetylornithinase) (AO) (N-acetylornithinase) (NAO). (383 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (259 aa)
argGArgininosuccinate synthase (Citrulline--aspartate ligase); Belongs to the argininosuccinate synthase family. Type 1 subfamily. (404 aa)
argHArgininosuccinate lyase (Arginosuccinase) (ASAL). (457 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (156 aa)
argIOrnithine carbamoyltransferase 1; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (336 aa)
pheCCyclohexadienyl dehydratase, putative. (274 aa)
serAD-3-phosphoglycerate dehydrogenase (PGDH), D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding. (412 aa)
argAAmino-acid acetyltransferase (N-acetylglutamate synthase) (AGS) (NAGS); Belongs to the acetyltransferase family. ArgA subfamily. (451 aa)
tyrAT-protein [Includes: Chorismate mutase (CM); Prephenate dehydrogenase (PDH)], Bifunctional chorismate mutase/prephenate dehydrogenase. (373 aa)
pheAP-protein [Includes: Chorismate mutase (CM); Prephenate dehydratase (PDT)], Bifunctional chorismate mutase/prephenate dehydratase. (386 aa)
aroLShikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa)
asnBAsparagine synthase B; Asparagine synthetase [glutamine-hydrolyzing] (AS). (554 aa)
ybiBAnthranilate phosphoribosyltransferase, Glycosyl transferase, family 3, Glycosyl transferase family, helical bundle domain. (323 aa)
ybiKL-asparaginase precursor (L-asparagine amidohydrolase) [Contains: L-asparaginase subunit alpha; L-asparaginase subunit beta], Peptidase T2, asparaginase 2, Asparaginase. (315 aa)
serC3-phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa)
aspCAspartate aminotransferase, chloroplast precursor (Transaminase A), Pyridoxal phosphate-dependent transferase. (396 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (309 aa)
trpEAnthranilate synthase component 1. (520 aa)
trpGAnthranilate synthase component II (Glutamine amido-transferase), Glutamine amidotransferase of anthranilate synthase. (197 aa)
trpDAnthranilate phosphoribosyltransferase / anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (332 aa)
trpCTryptophan biosynthesis protein trpCF [Includes: Indole-3-glycerol phosphate synthase (IGPS); N-(5'-phospho-ribosyl)anthranilate isomerase (PRAI)]. (453 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
ansAL-asparaginase, type I. (373 aa)
pabBPara-aminobenzoate synthase component 1 (Para-aminobenzoate synthase component I) (ADC synthase). (455 aa)
sdaAL-serine dehydratase 1 (L-serine deaminase 1) (SDH 1) (L-SD1), Iron-sulphur-dependent L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
yeeZdTDP-glucose 4,6-dehydratase; 6-phosphogluconate dehydrogenase, NAD-binding. (275 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa)
hisCHistidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase) (HspAT) (HPAT), Pyridoxal phosphate-dependent transferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (363 aa)
hisBHistidine biosynthesis bifunctional protein hisB [Includes: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase (IGPD)]. (355 aa)
hisHImidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa)
hisAN-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase), Histidine biosynthesis protein. (245 aa)
hisFImidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
hisIHistidine biosynthesis bifunctional protein hisIE [Includes: Phosphoribosyl-AMP cyclohydrolase (PRA-CH); Phosphoribosyl-ATP pyrophosphatase (PRA-PH)]; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
yeaKProlyl-tRNA synthetase (Proline-tRNA ligase) (ProRS), YbaK/prolyl-tRNA synthetase associated region, YbaK / prolyl-tRNA synthetases associated domain. (158 aa)
aroQ5Putative chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. (183 aa)
aat3Probable aspartate aminotransferase (Transaminase A) (ASPAT), Pyridoxal phosphate-dependent transferase, major region, Aminotransferase class I and II, tyr_amTase_E: tyrosine aminotransferase. (405 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (THP succinyltransferase) (Tetrahydropicolinate succinylase); Belongs to the transferase hexapeptide repeat family. (274 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
thrCThreonine synthase, Pyridoxal-phosphate dependent enzyme. (428 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
thrABifunctional aspartokinase/homoserine dehydrogenase I (AKI-HDI) [Includes: Aspartokinase I; Homoserine dehydrogenase I ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. (801 aa)
serBPhosphoserine phosphatase (PSP) (O-phosphoserine phosphohydrolase) (PSPase). (325 aa)
aspAAspartate ammonia-lyase. (478 aa)
asnB2Putative asparagine synthetase [glutamine-hydrolyzing] (AS). (529 aa)
lysCLysine-sensitive aspartokinase III; Aspartate kinase; Belongs to the aspartokinase family. (450 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
argDBifunctional acetylornithine delta-aminotransferase / N-succinyldiaminopimelate aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
pabAGlutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase. (192 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (369 aa)
yhhYUncharacterized acetyltransferase p20, GCN5-related N-acetyltransferase, Acetyltransferase (GNAT) family. (168 aa)
Your Current Organism:
Erwinia amylovora
NCBI taxonomy Id: 665029
Other names: E. amylovora CFBP1430, Erwinia amylovora CFBP1430, Erwinia amylovora str. CFBP1430, Erwinia amylovora strain CFBP1430
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