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ygfZ ygfZ ygfY ygfY EAMY_0649 EAMY_0649 ygdK ygdK csdA csdA miaB miaB yccV yccV yccW yccW yccK yccK yccA yccA EAMY_1401 EAMY_1401 EAMY_1402 EAMY_1402 ycfD ycfD ycfC ycfC ycfB ycfB ymfB ymfB ymfC ymfC sufA sufA sufB sufB sufC sufC sufD sufD sufS sufS sufE sufE EAMY_1794 EAMY_1794 ydaO ydaO sohB sohB yciK yciK sixA sixA EAMY_2435 EAMY_2435 iscS iscS iscR iscR yfhQ yfhQ EAMY_2769 EAMY_2769 yadR yadR djlA djlA yheL yheL yheM yheM yheN yheN yheO yheO fkpA fkpA slyX slyX yhgI yhgI yhhP yhhP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ygfZtRNA-modifying protein ygfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. (328 aa)
ygfYUPF0350 protein plu3555; Protein of unknown function DUF339, Protein of unknown function (DUF339). (88 aa)
EAMY_0649Uncharacterized protein ygfX; Protein of unknown function DUF1434, Protein of unknown function (DUF1434). (114 aa)
ygdKCysteine desulfuration protein sufE; Fe-S metabolism associated SufE, Fe-S metabolism associated domain. (149 aa)
csdACysteine sulfinate desulfinase; Pyridoxal phosphate-dependent transferase, major region, Aminotransferase class-V, sufS: cysteine desulfurases, SufS subfamily. (402 aa)
miaBUPF0004 protein PA3980; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (480 aa)
yccVUncharacterized protein yccV; Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress; Belongs to the HspQ family. (105 aa)
yccWUPF0064 protein yccW; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. (396 aa)
yccKPutative sulfite reductase; Part of a sulfur-relay system. (108 aa)
yccAUncharacterized protein PM0402; Protein of unknown function UPF0005, Uncharacterised protein family UPF0005; Belongs to the BI1 family. (218 aa)
EAMY_1401Hypothetical protein predicted by Glimmer/Critica. (58 aa)
EAMY_1402Hypothetical protein predicted by Glimmer/Critica. (36 aa)
ycfDUncharacterized protein ycfD; Cupin 4, Cupin superfamily protein. (375 aa)
ycfCUPF0274 protein ycfC; Protein of unknown function DUF489, Protein of unknown function (DUF489). (214 aa)
ycfBtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. (369 aa)
ymfBPutative phosphohydrolase; NUDIX, NUDIX domain; Belongs to the Nudix hydrolase family. NudJ subfamily. (158 aa)
ymfCRibosomal large subunit pseudouridine synthase E (rRNA-uridine isomerase E) (rRNA pseudouridylate synthase E), Pseudouridine synthase, Rsu, RNA pseudouridylate synthase, TIGR00093: conserved hypothetical protein; Belongs to the pseudouridine synthase RsuA family. (218 aa)
sufASUF system FeS cluster assembly, SufA scaffold; Belongs to the HesB/IscA family. (124 aa)
sufBSUF system FeS cluster assembly, SufB. (497 aa)
sufCsufC: FeS assembly ATPase SufC. (248 aa)
sufDSUF system FeS cluster assembly, SufD. (426 aa)
sufSCysteine desulfurase SufS; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)
sufECysteine desulfuration protein sufE; Fe-S metabolism associated SufE. (140 aa)
EAMY_1794Transcriptional regulator, Rrf2, Transcriptional regulator. (152 aa)
ydaOUPF0021 protein HI1371.1; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (309 aa)
sohBPutative protease; Peptidase S49, N-terminal proteobacteria, Peptidase family S49 N-terminal, SppA_dom: signal peptide peptidase SppA, 36K type. (349 aa)
yciKShort-chain dehydrogenase/reductase SDR. (255 aa)
sixAPhosphohistidine phosphatase sixA (RX6), Phosphohistidine phosphatase SixA, subgroup, sixA: phosphohistidine phosphatase SixA. (160 aa)
EAMY_2435Hypothetical protein predicted by Glimmer/Critica. (57 aa)
iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (399 aa)
iscRHTH-type transcriptional regulator iscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (165 aa)
yfhQPutative RNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (241 aa)
EAMY_2769Hypothetical protein predicted by Glimmer/Critica. (49 aa)
yadRUncharacterized protein HI1723; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa)
djlADnaJ-like protein djlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. (274 aa)
yheLPutative tRNA 2-thiouridine synthesizing protein B; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. (95 aa)
yheMProtein tusC (tRNA 2-thiouridine synthesizing protein C); Belongs to the DsrF/TusC family. (119 aa)
yheNPutative tRNA 2-thiouridine synthesizing protein D; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE. (128 aa)
yheOUncharacterized protein yheO; YheO-like, YheO-like PAS domain. (240 aa)
fkpAFKBP-type peptidyl-prolyl cis-trans isomerase fkpA precursor (PPIase) (Rotamase). (278 aa)
slyXProtein slyX homolog; SlyX, SlyX; Belongs to the SlyX family. (72 aa)
yhgIProtein gntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (191 aa)
yhhPSulfurtransferase tusA; Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin. (81 aa)
Your Current Organism:
Erwinia amylovora
NCBI taxonomy Id: 665029
Other names: E. amylovora CFBP1430, Erwinia amylovora CFBP1430, Erwinia amylovora str. CFBP1430, Erwinia amylovora strain CFBP1430
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