(22 nodes) Mixed, incl. Sigma-54 interaction domain, ATP-binding site 2, and Regulation of nitrogen utilization network (Erwinia amylovora)

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Your Input:
	glnG	Transcriptional regulatory protein glnG; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (469 aa)
	glnL	Histidine protein kinase sensor for GlnG regulator (nitrogen regulator II, NRII), Two-component nitrogen regulation protein. (349 aa)
	rpoN	RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (477 aa)
	ygiM	Uncharacterized protein ygiM precursor; Bacterial SH3-like region. (206 aa)
	ygiF	Uncharacterized protein ygiF (ORFXE); Adenylate cyclase, CYTH domain. (434 aa)
	glnE	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (944 aa)
	glnK	Nitrogen regulatory PII-like, alpha/beta; Belongs to the P(II) protein family. (112 aa)
	amtB	Ammonium transporter, TC 1.A.11.1.1 Ammonia channel. (433 aa)
	tyrR	Transcriptional regulatory protein tyrR; RNA polymerase sigma factor 54, interaction, Sigma-54 interaction domain, phageshock_pspF: psp operon transcriptional activator PspF. (521 aa)
	ycjF	UPF0283 membrane protein plu2581; Conserved hypothetical protein CHP01620, Family of unknown function (DUF697), hyp_HI0043: conserved hypothetical protein TIGR01620. (350 aa)
	ycjX	Protein of unknown function DUF463, YcjX-like protein, YcjX-like family, DUF463. (465 aa)
	pspD	Phage shock protein PspD. (69 aa)
	pspC	Phage shock protein C. (115 aa)
	pspB	Phage shock protein B. (75 aa)
	pspA	Phage shock protein A. (223 aa)
	pspF	Transcriptional activator, PspF, psp operon transcriptional activator PspF. (330 aa)
	acoR	Signal-transduction and transcriptional-control protein; RNA polymerase sigma factor 54, interaction, Sigma-54 interaction domain, ntrC: nitrogen regulation protein NR(I). (643 aa)
	glnB	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family. (112 aa)
	yfhA	Two-component system response regulator; RNA polymerase sigma factor 54, interaction. (444 aa)
	yfhG	Uncharacterized protein yfhG. (240 aa)
	yfhK	Putative sensor-like histidine kinase yfhK, Histidine kinase, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (479 aa)
	glnD	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (885 aa)

Your Current Organism:

Erwinia amylovora

NCBI taxonomy Id: 665029
Other names: E. amylovora CFBP1430, Erwinia amylovora CFBP1430, Erwinia amylovora str. CFBP1430, Erwinia amylovora strain CFBP1430

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acoR	rpoN	EAMY_2197	EAMY_0316	Signal-transduction and transcriptional-control protein; RNA polymerase sigma factor 54, interaction, Sigma-54 interaction domain, ntrC: nitrogen regulation protein NR(I).	RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.809
amtB	glnB	EAMY_0996	EAMY_2606	Ammonium transporter, TC 1.A.11.1.1 Ammonia channel.	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family.	0.997
amtB	glnD	EAMY_0996	EAMY_2762	Ammonium transporter, TC 1.A.11.1.1 Ammonia channel.	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	0.449
amtB	glnK	EAMY_0996	EAMY_0995	Ammonium transporter, TC 1.A.11.1.1 Ammonia channel.	Nitrogen regulatory PII-like, alpha/beta; Belongs to the P(II) protein family.	0.999
amtB	glnL	EAMY_0996	EAMY_0035	Ammonium transporter, TC 1.A.11.1.1 Ammonia channel.	Histidine protein kinase sensor for GlnG regulator (nitrogen regulator II, NRII), Two-component nitrogen regulation protein.	0.802
glnB	amtB	EAMY_2606	EAMY_0996	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family.	Ammonium transporter, TC 1.A.11.1.1 Ammonia channel.	0.997
glnB	glnD	EAMY_2606	EAMY_2762	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family.	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	0.977
glnB	glnG	EAMY_2606	EAMY_0034	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family.	Transcriptional regulatory protein glnG; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.	0.741
glnB	glnK	EAMY_2606	EAMY_0995	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family.	Nitrogen regulatory PII-like, alpha/beta; Belongs to the P(II) protein family.	0.764
glnB	glnL	EAMY_2606	EAMY_0035	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family.	Histidine protein kinase sensor for GlnG regulator (nitrogen regulator II, NRII), Two-component nitrogen regulation protein.	0.991
glnB	yfhA	EAMY_2606	EAMY_2607	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family.	Two-component system response regulator; RNA polymerase sigma factor 54, interaction.	0.754
glnB	yfhG	EAMY_2606	EAMY_2608	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family.	Uncharacterized protein yfhG.	0.758
glnB	yfhK	EAMY_2606	EAMY_2609	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family.	Putative sensor-like histidine kinase yfhK, Histidine kinase, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.736
glnD	amtB	EAMY_2762	EAMY_0996	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	Ammonium transporter, TC 1.A.11.1.1 Ammonia channel.	0.449
glnD	glnB	EAMY_2762	EAMY_2606	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	Nitrogen regulatory protein PII/ATP; Belongs to the P(II) protein family.	0.977
glnD	glnE	EAMY_2762	EAMY_0425	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.765
glnD	glnK	EAMY_2762	EAMY_0995	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	Nitrogen regulatory PII-like, alpha/beta; Belongs to the P(II) protein family.	0.791
glnD	glnL	EAMY_2762	EAMY_0035	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	Histidine protein kinase sensor for GlnG regulator (nitrogen regulator II, NRII), Two-component nitrogen regulation protein.	0.608
glnE	glnD	EAMY_0425	EAMY_2762	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	0.765
glnE	ygiF	EAMY_0425	EAMY_0424	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	Uncharacterized protein ygiF (ORFXE); Adenylate cyclase, CYTH domain.	0.875