STRINGSTRING
dcm1 dcm1 mcrB mcrB EAMY_0065 EAMY_0065 speC speC speA speA speB speB luxS luxS yafV yafV ybdL ybdL EAMY_0871 EAMY_0871 EAMY_0872 EAMY_0872 mtnB mtnB masA masA mtnD mtnD eif eif mtnK mtnK expR expR expI expI EAMY_2029 EAMY_2029 EAMY_2030 EAMY_2030 EAMY_2031 EAMY_2031 vsr vsr dcm3 dcm3 speG speG htrA htrA dgt dgt pfs pfs EAMY_2768 EAMY_2768 speE speE speD speD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dcm1Modification methylase Eco47II (Cytosine-specific methyltransferase Eco47II) (M.Eco47II), C-5 cytosine-specific DNA methylase, C-5 cytosine-specific DNA methylase, dcm: DNA-cytosine methyltransferase. (379 aa)
mcrBATPase associated with various cellular activities, AAA-5. (534 aa)
EAMY_0065Hypothetical protein predicted by Glimmer/Critica. (425 aa)
speCOrnithine decarboxylase (ODC). (714 aa)
speAArginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (658 aa)
speBAgmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily. (307 aa)
luxSAutoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
yafVUPF0012 hydrolase in agr operon (ORF 5) (Fragment), Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase. (255 aa)
ybdLPutative aminotransferase; Kynurenine-oxoglutarate transaminase 3 (Kynurenine-oxoglutarate transaminase III) (Kynurenine aminotransferase III) (KATIII) (Cysteine-S-conjugate beta-lyase 2), Pyridoxal phosphate-dependent transferase, major region, Aminotransferase class I and II. (386 aa)
EAMY_0871Hypothetical protein predicted by Glimmer/Critica. (34 aa)
EAMY_0872Hypothetical protein predicted by Glimmer/Critica. (155 aa)
mtnBHypothetical protein; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (204 aa)
masAEnolase-phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (229 aa)
mtnDDioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (180 aa)
eifPutative translation initiation factor EIF-2B; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (343 aa)
mtnK5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (399 aa)
expRTranscriptional activator protein ExpR; Bacterial regulatory protein, luxR family, C-terminal (transduction) domain. (240 aa)
expIPutative autoinducer synthesis protein, shows similarity with phzI of Pseudomonas chlororaphis. (207 aa)
EAMY_2029Hypothetical protein predicted by Glimmer/Critica. (97 aa)
EAMY_2030Spermidine synthase 1 (Putrescine aminopropyltransferase 1) (SPDSY 1). (269 aa)
EAMY_2031Putative AI-2E family transporter; Protein of unknown function UPF0118/DUF20, TC 2.A.86.1.-The Autoinducer-2 Exporter (AI-2E) Family (formerly the PerM Family, TC #9.B.22). (372 aa)
vsrPatch repair protein; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. (155 aa)
dcm3C-5 cytosine-specific DNA methylase. (469 aa)
speGSpermidine N(1)-acetyltransferase (Diamine acetyltransferase) (SAT). (188 aa)
htrAProbable serine protease do-like precursor; Belongs to the peptidase S1C family. (485 aa)
dgtDeoxyguanosine triphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (501 aa)
pfs5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenos [...] (243 aa)
EAMY_2768Hypothetical protein predicted by Glimmer/Critica. (81 aa)
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (285 aa)
speDS-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (267 aa)
Your Current Organism:
Erwinia amylovora
NCBI taxonomy Id: 665029
Other names: E. amylovora CFBP1430, Erwinia amylovora CFBP1430, Erwinia amylovora str. CFBP1430, Erwinia amylovora strain CFBP1430
Server load: low (12%) [HD]