STRINGSTRING
hslU hslU hslV hslV yhbY yhbY ftsJ ftsJ ftsH ftsH EAMY_0345 EAMY_0345 clpB1 clpB1 ygdP ygdP lgt lgt rsmA rsmA clpB3 clpB3 clpP clpP clpX clpX clpP2 clpP2 clpX2 clpX2 lon lon htpG htpG ybbJ ybbJ ybbK ybbK ybbN ybbN ybbO ybbO EAMY_1043 EAMY_1043 cspD cspD EAMY_1324 EAMY_1324 clpS clpS clpA clpA himD himD himA himA EAMY_1834 EAMY_1834 htpX htpX yegD yegD sseB sseB ydfT ydfT grpE grpE dksA dksA dnaJ dnaJ dnaK dnaK clpV1 clpV1 hflC hflC hflK hflK hflX hflX hfq hfq miaA miaA amiB amiB yjeE yjeE yjeF yjeF EAMY_3163 EAMY_3163 groL groL groE groE fxsA fxsA clpV3 clpV3 EAMY_3440 EAMY_3440 yrfH yrfH yrfI yrfI ibpA ibpA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hslUATP-dependent hsl protease ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (443 aa)
hslVATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (176 aa)
yhbYCRS2-associated factor 1, mitochondrial precursor; CRS1/YhbY, CRS1 / YhbY domain, TIGR00253: conserved hypothetical protein TIGR00253. (97 aa)
ftsJCell division protein; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (209 aa)
ftsHCell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (647 aa)
EAMY_0345Hypothetical protein predicted by Glimmer/Critica. (42 aa)
clpB1Chaperone protein clpB; ATPase AAA-2. (211 aa)
ygdPPutative invasion protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (175 aa)
lgtProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (292 aa)
rsmACarbon storage regulator homolog; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa)
clpB3ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
clpPATP-dependent Clp protease proteolytic subunit clpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (207 aa)
clpXATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa)
clpP2Putative ATP-dependent Clp protease, proteolytic subunit ClpP2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (198 aa)
clpX2ATP-dependent Clp protease ATP-binding subunit clpX2; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa)
lonDNA-binding ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (784 aa)
htpGChaperone protein htpG; Molecular chaperone. Has ATPase activity. (624 aa)
ybbJInner membrane protein ybbJ; Nodulation efficiency, NfeD, NfeD-like. (150 aa)
ybbKUncharacterized protein slr1128; Band 7 protein, SPFH domain / Band 7 family. (304 aa)
ybbNUncharacterized protein ybbN; Tetratricopeptide-like helical, Thioredoxin, thioredoxin: thioredoxin. (285 aa)
ybbOPutative oxidoreductase; 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase), Short-chain dehydrogenase/reductase SDR, short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)
EAMY_1043Hypothetical protein predicted by Glimmer/Critica. (48 aa)
cspDCold shock domain protein CspD. (75 aa)
EAMY_1324Hypothetical protein predicted by Glimmer/Critica. (39 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (106 aa)
clpAChaperone protein clpA; ATP-dependent Clp protease ATP-binding subunit clpA; Belongs to the ClpA/ClpB family. (758 aa)
himDIntegration host factor beta-subunit (IHF-beta); This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (95 aa)
himAIntegration host factor subunit alpha (IHF-alpha); This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (99 aa)
EAMY_1834Hypothetical protein predicted by Glimmer/Critica. (90 aa)
htpXPutative heat shock protein; Peptidase M48, Ste24p, HtpX N-terminus; Belongs to the peptidase M48B family. (293 aa)
yegDPutative chaperone. (450 aa)
sseBSseB, SseB protein. (259 aa)
ydfTAntitermination protein. (258 aa)
grpEProtein grpE (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] (194 aa)
dksADnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. (151 aa)
dnaJChaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (381 aa)
dnaKChaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (637 aa)
clpV1Putative type VI secretion system, core protein COG542: ATPases with chaperone activity, ATP-binding subunit ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. (871 aa)
hflCProtease specific for phage lambda cII repressor; HflC and HflK could regulate a protease. (334 aa)
hflKProtease specific for phage lambda cII repressor; HflC and HflK could encode or regulate a protease. (417 aa)
hflXGTP-binding protein hflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (426 aa)
hfqProtein hfq (Host factor-I protein) (HF-I) (HF-1); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (103 aa)
miaADelta(2)-isopentenylpyrophosphate tRNA-adenosine transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (316 aa)
amiBN-acetylmuramoyl-L-alanine amidase amiB precursor. (551 aa)
yjeEProtein of unknown function UPF0079, ATPase bacteria, Uncharacterised P-loop hydrolase UPF0079, TIGR00150: conserved hypothetical protein TIGR00150. (158 aa)
yjeFUncharacterized protein yjeF; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...] (506 aa)
EAMY_3163Hypothetical protein predicted by Glimmer/Critica. (40 aa)
groL60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
groE10 kDa chaperonin (Protein Cpn10) (groES protein); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (97 aa)
fxsAProtein fxsA (Suppressor of F exclusion of phage T7) (Fragment), FxsA cytoplasmic membrane protein, FxsA cytoplasmic membrane protein. (288 aa)
clpV3Putative type VI secretion system, core protein COG542: ATPases with chaperone activity, ATP-binding subunit ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. (886 aa)
EAMY_3440Hypothetical protein predicted by Glimmer/Critica. (31 aa)
yrfHPutative heat shock protein 15 (HSP15); Belongs to the HSP15 family. (133 aa)
yrfI33 kDa chaperonin (Heat shock protein 33) (HSP33); Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. (292 aa)
ibpASmall heat shock protein hspB; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent. (139 aa)
Your Current Organism:
Erwinia amylovora
NCBI taxonomy Id: 665029
Other names: E. amylovora CFBP1430, Erwinia amylovora CFBP1430, Erwinia amylovora str. CFBP1430, Erwinia amylovora strain CFBP1430
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.