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kdtA kdtA ddg ddg degS degS degQ degQ yhcB yhcB yhcM yhcM sspA sspA sspB sspB yhbG yhbG yhbN yhbN yrbK yrbK yrbI yrbI yrbH yrbH yrbG yrbG yrbF yrbF yrbE yrbE yrbD yrbD yrbC yrbC yrbB yrbB yrbA yrbA murA murA yjgP yjgP ampH1 ampH1 cca cca exbB exbB exbD exbD yfiO yfiO ybbF ybbF ppiB ppiB rlpB rlpB ybgC ybgC tolQ tolQ tolR tolR tolA tolA tolB tolB pal pal ybgF ybgF EAMY_1335 EAMY_1335 lolA lolA ycaJ ycaJ serS serS lpxK lpxK kdsB kdsB ompA ompA htrB htrB mviN mviN ycfU ycfU ycfV ycfV ycfW ycfW kdsA kdsA tonB tonB msbB msbB ompC ompC nlpB nlpB yfgL yfgL smpA smpA rnhB rnhB lpxB lpxB lpxA lpxA fabZ fabZ lpxD lpxD hlpA hlpA yaeT yaeT yaeL yaeL cdsA cdsA uppS uppS mdeA1 mdeA1 lpxC lpxC imp imp surA surA pdxA pdxA ksgA ksgA apaG apaG apaH apaH srlQ srlQ yjeR yjeR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kdtA3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (424 aa)
ddgLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa)
degSProbable serine protease do-like precursor, Peptidase S1C, DegS. (366 aa)
degQProbable serine protease do-like precursor, Peptidase S1C, Do; Belongs to the peptidase S1C family. (461 aa)
yhcBPutative cytochrome d ubiquinol oxidase subunit III (Cytochrome bd-I oxidase subunit III), Protein of unknown function DUF1043, Protein of unknown function (DUF1043). (132 aa)
yhcMUncharacterized protein yhcM; Reduces the stability of FtsZ polymers in the presence of ATP. (375 aa)
sspAStringent starvation protein A homolog; Glutathione S-transferase, C-terminal-like, Glutathione S-transferase, N-terminal domain; Belongs to the GST superfamily. (213 aa)
sspBStringent starvation protein B, Stringent starvation protein B. (165 aa)
yhbGLPS export porin complex, cytoplasmic ABC-type ATPase subunit, TC 1.B.42.1.2 Uncharacterized ABC transporter ATP-binding protein yhbG. (241 aa)
yhbNLPS export porin complex, periplasmic chaparone precursor; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (183 aa)
yrbKLPS export porin complex, LptC subunit; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (189 aa)
yrbIPutative 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (188 aa)
yrbHPutative isomerase; KpsF/GutQ, SIS domain, kpsF: sugar isomerase, KpsF/GutQ family. (329 aa)
yrbGCa(2+)/H(+) exchanger, TC 2.A.19.5.1 putative Ca2+:H+ antiporter. (326 aa)
yrbFABC transporter related, TC 3.A.1.-.-The ATP-binding Cassette (ABC) Superfamily. (270 aa)
yrbEUPF0393 inner membrane protein yrbE; Protein of unknown function DUF140, Domain of unknown function DUF140, TIGR00056: conserved hypothetical protein. (260 aa)
yrbDUncharacterized protein yrbD precursor; Mammalian cell entry related, mce related protein. (182 aa)
yrbCProtein yrbC precursor. (211 aa)
yrbBUncharacterized protein yrbB; Sulphate transporter/antisigma-factor antagonist STAS. (98 aa)
yrbAUncharacterized protein yrbA; BolA-like protein, BolA-like protein; Belongs to the BolA/IbaG family. (84 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa)
yjgPPredicted permease YjgP, TC 9.B.93.1.1 Inner membrane protein yjgP. (366 aa)
ampH1beta-lactamase/D-alanine carboxypeptidase. (358 aa)
ccatRNA nucleotidyltransferase (CCA-adding enzyme); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (408 aa)
exbBBiopolymer transport exbB protein; TonB-system energizer ExbB type-1, MotA/TolQ/ExbB proton channel family, TC 2.C.1.1.1 Biopolymer transport exbB protein. (239 aa)
exbDBiopolymer transport protein ExbD/TolR, TC 2.C.1.1.1 Biopolymer transport protein exbD. (140 aa)
yfiOUPF0169 lipoprotein PD_1756 precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (243 aa)
ybbFUDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (238 aa)
ppiBPeptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
rlpBLPS-assembly lipoprotein rlpB precursor; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (199 aa)
ybgCTol-Pal system-associated acyl-CoA thioesterase. (134 aa)
tolQProtein tolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (225 aa)
tolRProtein tolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (142 aa)
tolATol-Pal system, TolA, TC 2.C.1.2.1 TolA protein. (392 aa)
tolBProtein tolB precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (430 aa)
palPeptidoglycan-associated lipoprotein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (172 aa)
ybgFHypothetical protein ybgF precursor; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (259 aa)
EAMY_1335Hypothetical protein predicted by Glimmer/Critica. (41 aa)
lolAOuter-membrane lipoprotein carrier protein precursor; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (203 aa)
ycaJUncharacterized protein ycaJ; AAA ATPase, core, ATPase family associated with various cellular activities (AAA). (447 aa)
serSSeryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (326 aa)
kdsBCTP:CMP-3-deoxy-D-manno-octulosonatetransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa)
ompAOuter membrane protein A precursor (Outer membrane protein II), TC 1.B.6.1.1 Outer membrane protein A; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (355 aa)
htrBLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa)
mviNIntegral membrane protein mviN homolog; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (512 aa)
ycfULipoprotein releasing system, transmembrane protein, LolC/E family, TC 3.A.1.125.1 Lipoprotein-releasing system transmembrane protein lolC. (399 aa)
ycfVLipoprotein-releasing system ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (234 aa)
ycfWLipoprotein releasing system, transmembrane protein, LolC/E family, TC 3.A.1.125.1 Lipoprotein releasing system transmembrane protein lolE. (414 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase); 2-dehydro-3-deoxyphosphooctonate aldolase (Phospho-2-dehydro-3-deoxyoctonate aldolase) (3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase) (KDO-8-phosphate synthetase) (KDO 8-P synthase) (KDOPS); Belongs to the KdsA family. (284 aa)
tonBProtein tonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (241 aa)
msbBLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa)
ompCPorin, Gram-negative type, TC 1.B.1.1.3 outer membrane protein C precursor (porin ompC)(outer membrane protein 1B); Belongs to the Gram-negative porin family. (368 aa)
nlpBLipoprotein 34 precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (343 aa)
yfgLUncharacterized protein RP232; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (393 aa)
smpASmall protein A precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (115 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (211 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (381 aa)
lpxAAcyl-ACP-UDP-N- acetylglucosamineacetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
fabZ(3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (151 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (340 aa)
hlpAOuter membrane chaperone Skp (OmpH), Outer membrane protein (OmpH-like); Belongs to the skp family. (171 aa)
yaeTOuter membrane protein assembly factor yaeT precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (803 aa)
yaeLPeptidase M50, putative membrane-associated zinc metallopeptidase, Peptidase family M50, TIGR00054: membrane-associated zinc metalloprotease, putative. (449 aa)
cdsAPhosphatidate cytidylyltransferase (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) (CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase); Belongs to the CDS family. (285 aa)
uppSUndecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (250 aa)
mdeA1Methionine gamma-lyase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (481 aa)
lpxCUDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa)
impLPS-assembly protein precursor; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (791 aa)
surASurvival protein SurA precursor; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (431 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (332 aa)
ksgAS-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (275 aa)
apaGApaG, Protein of unknown function (DUF525). (125 aa)
apaHDiadenosine tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (274 aa)
srlQProbable phosphosugar isomerase. (321 aa)
yjeROligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (193 aa)
Your Current Organism:
Erwinia amylovora
NCBI taxonomy Id: 665029
Other names: E. amylovora CFBP1430, Erwinia amylovora CFBP1430, Erwinia amylovora str. CFBP1430, Erwinia amylovora strain CFBP1430
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