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metL metL gpsA gpsA ilvC ilvC wecC wecC fadB fadB murB murB mdh mdh serA serA ribD ribD apbA apbA panE panE EAMY_3094 EAMY_3094 thrA thrA pdxA pdxA leuB leuB ispC ispC guaB guaB fadJ fadJ pdxB pdxB adhC1 adhC1 sfcA sfcA gnd gnd hisD hisD adhB adhB zwf zwf ugd ugd sldC sldC sldL sldL adhE3 adhE3 adhE1 adhE1 ldhA ldhA icdA icdA fabG fabG ygbJ ygbJ yfbG yfbG adhP adhP EAMY_3265 EAMY_3265 EAMY_3266 EAMY_3266 EAMY_3267 EAMY_3267 adhC3 adhC3 aroE aroE iolG iolG yjgB yjgB dalD dalD yahK yahK mtlD mtlD yiaE yiaE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
metLBifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. (811 aa)
gpsAGlycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (492 aa)
wecCUDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
fadBFatty acid oxidation complex subunit alpha FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (728 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (345 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
serAD-3-phosphoglycerate dehydrogenase (PGDH), D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding. (412 aa)
ribDDiaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa)
apbA2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (306 aa)
panEProbable 2-dehydropantoate 2-reductase (KPA reductase) (KPR). (304 aa)
EAMY_3094Zn-dependent dehydrogenases; Alcohol dehydrogenase superfamily, zinc-containing. (353 aa)
thrABifunctional aspartokinase/homoserine dehydrogenase I (AKI-HDI) [Includes: Aspartokinase I; Homoserine dehydrogenase I ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. (801 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (332 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (362 aa)
ispC1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (404 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
fadJFatty acid oxidation complex subunit alpha; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (715 aa)
pdxBErythronate-4-phosphate dehyrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (397 aa)
adhC1Alcohol dehydrogenase class 3 (Alcohol dehydrogenase 2) (S-(hydroxymethyl)glutathione dehydrogenase) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH) (Alcohol dehydrogenase-B2), Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase, Alcohol dehydrogenase GroES-like domain, adh_III_F_hyde: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa)
sfcAMalic enzyme, NAD-binding. (565 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa)
adhBAlcohol dehydrogenase, zinc-containing; Alcohol dehydrogenase 1 (Alcohol dehydrogenase alpha subunit) (ADH3), Alcohol dehydrogenase superfamily, zinc-containing. (351 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
ugdPutative nucleotide sugar dehydrogenase; UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH). (446 aa)
sldCAlcohol dehydrogenase cytochrome c subunit precursor (Cytochrome c-553) (Cytochrome c553) (G3-ADH subunit II), Membrane-bound alcohol dehydrogenase, cytochrome c subunit. (437 aa)
sldLFAD dependent oxidoreductase. (533 aa)
adhE31.2.1.10] [KO:K00001 K04072], Aldehyde-alcohol dehydrogenase [Includes: Alcohol dehydrogenase (ADH); Acetaldehyde dehydrogenase [acetylating] (ACDH)], Iron-containing alcohol dehydrogenase, Iron-containing alcohol dehydrogenase, lactal_redase: lactaldehyde reductase. (716 aa)
adhE1Aldehyde-alcohol dehydrogenase [Includes: Alcohol dehydrogenase (ADH); Acetaldehyde dehydrogenase [acetylating] (ACDH)], Aldehyde dehydrogenase. (160 aa)
ldhAFermentative D-lactate dehydrogenase, NAD-dependent; D-lactate dehydrogenase (D-LDH) (D-specific D-2-hydroxyacid dehydrogenase), D-isomer specific 2-hydroxyacid dehydrogenase. (330 aa)
icdAIsocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP), Isocitrate dehydrogenase NADP-dependent, prokaryotic. (416 aa)
fabG3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
ygbJ3-hydroxyacid dehydrogenase/reductase. (304 aa)
yfbGBifunctional polymyxin resistance protein arnA; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (660 aa)
adhPAlcohol dehydrogenase superfamily, zinc-containing, Zinc-binding dehydrogenase, adh_fam_2: zinc-binding alcohol dehydrogenase family protein. (338 aa)
EAMY_3265Membrane-bound alcohol dehydrogenase, cytochrome c subunit. (438 aa)
EAMY_3266Gluconate 2-dehydrogenase (acceptor), alpha chain. (594 aa)
EAMY_3267Gluconate 2-dehydrogenase subunit 3 precursor (GADH subunit 3) (GA 2-DH subunit 3). (245 aa)
adhC3Zinc-type alcohol dehydrogenase-like protein, Alcohol dehydrogenase superfamily, zinc-containing. (350 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
iolGMyo-inositol 2-dehydrogenase; Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose). (342 aa)
yjgBCinnamyl alcohol dehydrogenase 2 (CAD 2), Alcohol dehydrogenase superfamily, zinc-containing, Zinc-binding dehydrogenase, adh_fam_2: zinc-binding alcohol dehydrogenase family protein. (338 aa)
dalDMannitol dehydrogenase. (467 aa)
yahKAlcohol dehydrogenase superfamily, zinc-containing. (348 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase. (382 aa)
yiaEPutative dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (321 aa)
Your Current Organism:
Erwinia amylovora
NCBI taxonomy Id: 665029
Other names: E. amylovora CFBP1430, Erwinia amylovora CFBP1430, Erwinia amylovora str. CFBP1430, Erwinia amylovora strain CFBP1430
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