node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAMY_2553 | ygbJ | EAMY_2553 | EAMY_1099 | NAD dependent epimerase/dehydratase family protein. | 3-hydroxyacid dehydrogenase/reductase. | 0.723 |
aroE | metL | EAMY_3345 | EAMY_0139 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.653 |
aroE | thrA | EAMY_3345 | EAMY_2951 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Bifunctional aspartokinase/homoserine dehydrogenase I (AKI-HDI) [Includes: Aspartokinase I; Homoserine dehydrogenase I ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.607 |
asd | dapB | EAMY_3471 | EAMY_2933 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.608 |
asd | metL | EAMY_3471 | EAMY_0139 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.994 |
asd | thrA | EAMY_3471 | EAMY_2951 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Bifunctional aspartokinase/homoserine dehydrogenase I (AKI-HDI) [Includes: Aspartokinase I; Homoserine dehydrogenase I ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.994 |
dapB | asd | EAMY_2933 | EAMY_3471 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.608 |
dapB | metL | EAMY_2933 | EAMY_0139 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.599 |
dapB | thrA | EAMY_2933 | EAMY_2951 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Bifunctional aspartokinase/homoserine dehydrogenase I (AKI-HDI) [Includes: Aspartokinase I; Homoserine dehydrogenase I ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.599 |
folA | ribD | EAMY_2929 | EAMY_0959 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.406 |
gapA | proA | EAMY_1976 | EAMY_0890 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Gamma-glutamylphosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.522 |
gapA | ribD | EAMY_1976 | EAMY_0959 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.419 |
gapA | zwf | EAMY_1976 | EAMY_2054 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.898 |
gnd | zwf | EAMY_2229 | EAMY_2054 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.992 |
metL | aroE | EAMY_0139 | EAMY_3345 | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.653 |
metL | asd | EAMY_0139 | EAMY_3471 | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.994 |
metL | dapB | EAMY_0139 | EAMY_2933 | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.599 |
metL | proA | EAMY_0139 | EAMY_0890 | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Gamma-glutamylphosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.453 |
metL | ribD | EAMY_0139 | EAMY_0959 | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.766 |
metL | thrA | EAMY_0139 | EAMY_2951 | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; Homoserine dehydrogenase II ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Bifunctional aspartokinase/homoserine dehydrogenase I (AKI-HDI) [Includes: Aspartokinase I; Homoserine dehydrogenase I ]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.990 |