(68 nodes) ATP-dependent activity, acting on DNA, and DNA damage checkpoint signaling network (Sclerotinia sclerotiorum)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	SS1G_00007	Uncharacterized protein. (412 aa)
	SS1G_00033	Uncharacterized protein. (410 aa)
	SS1G_00095	Uncharacterized protein. (162 aa)
	SS1G_00994	Uncharacterized protein; Belongs to the RecA family. (325 aa)
	SS1G_01263	RECA_2 domain-containing protein. (493 aa)
	SS1G_01584	ERCC4 domain-containing protein. (631 aa)
	SS1G_01751	BRCT domain-containing protein. (1262 aa)
	SS1G_01930	Toprim domain-containing protein. (1846 aa)
	SS1G_01987	Uncharacterized protein. (653 aa)
	SS1G_02717	SAP domain-containing protein. (645 aa)
	msh3	DNA mismatch repair protein msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1130 aa)
	SS1G_03003	Uncharacterized protein. (318 aa)
	SS1G_03212	Uncharacterized protein. (1142 aa)
	SS1G_03224	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2697 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (907 aa)
	SS1G_03342	Uncharacterized protein. (805 aa)
	mph1	ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1235 aa)
	SS1G_04226	DNA_mis_repair domain-containing protein. (845 aa)
	SS1G_04335	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1246 aa)
	SS1G_04378	DNA_MISMATCH_REPAIR_2 domain-containing protein. (306 aa)
	SS1G_04500	Uncharacterized protein. (355 aa)
	SS1G_04501	Uncharacterized protein. (1200 aa)
	SS1G_04531	BRCT domain-containing protein. (1294 aa)
	SS1G_04551	Pectinesterase; Involved in maceration and soft-rotting of plant tissue. (332 aa)
	SS1G_04868	SAE2 domain-containing protein. (966 aa)
	SS1G_05508	Helicase ATP-binding domain-containing protein. (862 aa)
	SS1G_05690	3'-5' exonuclease domain-containing protein. (603 aa)
	SS1G_05799	DRMBL domain-containing protein. (1133 aa)
	SS1G_05802	Uncharacterized protein. (295 aa)
	SS1G_05883	Uncharacterized protein. (749 aa)
	SS1G_06612	BRCT domain-containing protein. (845 aa)
	SS1G_06712	DNA_MISMATCH_REPAIR_2 domain-containing protein. (977 aa)
	SS1G_06782	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (349 aa)
	SS1G_06882	Uncharacterized protein. (1559 aa)
	SS1G_07128	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (705 aa)
	SS1G_07546	Vezatin domain-containing protein. (318 aa)
	SS1G_07608	Uncharacterized protein. (753 aa)
	SS1G_07711	DNA_ligase_A_N domain-containing protein. (241 aa)
	SS1G_08608	DNA_mis_repair domain-containing protein. (745 aa)
	SS1G_08640	Uncharacterized protein. (363 aa)
	SS1G_08935	BRCT domain-containing protein. (940 aa)
	SS1G_08991	Checkpoint protein; Belongs to the HUS1 family. (340 aa)
	SS1G_09471	Uncharacterized protein. (518 aa)
	SS1G_09567	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (739 aa)
	SS1G_09785	DNA_mis_repair domain-containing protein. (912 aa)
	SS1G_09786	Uncharacterized protein. (94 aa)
	SS1G_10018	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (911 aa)
	SS1G_10638	Uncharacterized protein. (568 aa)
	SS1G_10757	Uncharacterized protein. (327 aa)
	SS1G_10870	MutL_C domain-containing protein. (618 aa)
	SS1G_10872	Uncharacterized protein. (84 aa)
	SS1G_11039	DNA ligase. (820 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (387 aa)
	SS1G_11392	Uncharacterized protein. (792 aa)
	SS1G_11597	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2165 aa)
	SS1G_12179	Protein kinase domain-containing protein. (532 aa)
	SS1G_12239	AAA_23 domain-containing protein. (1336 aa)
	SS1G_11798	DNA_MISMATCH_REPAIR_2 domain-containing protein. (402 aa)
	SS1G_11837	XPGI domain-containing protein. (743 aa)
	SS1G_11865	RMI1_N domain-containing protein. (148 aa)
	SS1G_11894	Uncharacterized protein. (861 aa)
	SS1G_12550	Uncharacterized protein. (938 aa)
	SS1G_12655	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (670 aa)
	SS1G_12833	Uncharacterized protein. (999 aa)
	SS1G_13301	Uncharacterized protein. (633 aa)
	SS1G_13713	DNA ligase. (914 aa)
	SS1G_14284	DNA_MISMATCH_REPAIR_2 domain-containing protein. (985 aa)
	SS1G_14422	Uncharacterized protein. (850 aa)

Your Current Organism:

Sclerotinia sclerotiorum

NCBI taxonomy Id: 665079
Other names: S. sclerotiorum 1980 UF-70, Sclerotinia sclerotiorum 1980 UF-70

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	PIF1	A7F0Q6	A7EDF0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	0.559
FEN1	SS1G_00007	A7F0Q6	A7E3Y5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.822
FEN1	SS1G_00033	A7F0Q6	A7E411	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.462
FEN1	SS1G_00095	A7F0Q6	A7E473	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.693
FEN1	SS1G_00994	A7F0Q6	A7E6R9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein; Belongs to the RecA family.	0.656
FEN1	SS1G_01263	A7F0Q6	A7E7I5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	RECA_2 domain-containing protein.	0.797
FEN1	SS1G_01584	A7F0Q6	A7E8F6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ERCC4 domain-containing protein.	0.838
FEN1	SS1G_01751	A7F0Q6	A7E8X3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	BRCT domain-containing protein.	0.530
FEN1	SS1G_01930	A7F0Q6	A7E9F0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Toprim domain-containing protein.	0.470
FEN1	SS1G_01987	A7F0Q6	A7E9K7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.679
FEN1	SS1G_02717	A7F0Q6	A7EBN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	SAP domain-containing protein.	0.688
FEN1	SS1G_03003	A7F0Q6	A7ECG4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.417
FEN1	SS1G_03224	A7F0Q6	A7ED35	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.572
FEN1	SS1G_03342	A7F0Q6	A7EDF2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.727
FEN1	SS1G_04226	A7F0Q6	A7EFY5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA_mis_repair domain-containing protein.	0.417
FEN1	SS1G_04335	A7F0Q6	A7EG94	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.859
FEN1	SS1G_04378	A7F0Q6	A7EGD7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.436
FEN1	SS1G_04500	A7F0Q6	A7EGQ8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.679
FEN1	SS1G_04501	A7F0Q6	A7EGQ9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.679
FEN1	SS1G_04531	A7F0Q6	A7EGT9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	BRCT domain-containing protein.	0.441