STRINGSTRING
ASAC_0915 ASAC_0915 ASAC_0905 ASAC_0905 ASAC_0094 ASAC_0094 ASAC_0096 ASAC_0096 ASAC_0097 ASAC_0097 lysS lysS hemA hemA ASAC_0104 ASAC_0104 ASAC_0106 ASAC_0106 ASAC_0111 ASAC_0111 ASAC_0113 ASAC_0113 ASAC_0114 ASAC_0114 ASAC_0117 ASAC_0117 cmk cmk ASAC_0130 ASAC_0130 glyS glyS ASAC_0139 ASAC_0139 ASAC_0140 ASAC_0140 ASAC_0141 ASAC_0141 ASAC_0143 ASAC_0143 cobS cobS cobD cobD ASAC_0150 ASAC_0150 ASAC_0151 ASAC_0151 ASAC_0155 ASAC_0155 ef1b ef1b ASAC_0171 ASAC_0171 rpl14e rpl14e ASAC_0188 ASAC_0188 tbp tbp priS priS rpl44e rpl44e ASAC_0203 ASAC_0203 adkA adkA rps8 rps8 rps14 rps14 rpl5 rpl5 rps4e rps4e rpl24 rpl24 rpl14 rpl14 rps17 rps17 rpl29 rpl29 rps3 rps3 rpl22 rpl22 rps19p rps19p metG metG cysS cysS rpl11 rpl11 alaS alaS rpl12 rpl12 rpl10 rpl10 rpl1 rpl1 eif2b eif2b serS serS ASAC_0272 ASAC_0272 ASAC_0273 ASAC_0273 nadE nadE ASAC_0275 ASAC_0275 prf1 prf1 ASAC_0280 ASAC_0280 ASAC_0285 ASAC_0285 ASAC_0287 ASAC_0287 tfe tfe ASAC_0297 ASAC_0297 rps17e rps17e gltX gltX ASAC_0336 ASAC_0336 ASAC_0337 ASAC_0337 pheS pheS argS argS ileS ileS ASAC_0365 ASAC_0365 fusA fusA proS proS dcd dcd nadK nadK pyrG pyrG ASAC_0403 ASAC_0403 ASAC_0410 ASAC_0410 atpE atpE atpA atpA atpB atpB ASAC_0421 ASAC_0421 rpoK rpoK rpl21e rpl21e ASAC_0427 ASAC_0427 ASAC_0430 ASAC_0430 ASAC_0444 ASAC_0444 ASAC_0455 ASAC_0455 aspS aspS ASAC_0465 ASAC_0465 gatA gatA gatB gatB ASAC_0474 ASAC_0474 ASAC_0481 ASAC_0481 atpD atpD ASAC_0502 ASAC_0502 trpS trpS ASAC_0526 ASAC_0526 ASAC_0533 ASAC_0533 ASAC_0539 ASAC_0539 ASAC_0552 ASAC_0552 ASAC_0582 ASAC_0582 rps27ae rps27ae rps24e rps24e ASAC_0597 ASAC_0597 ASAC_0610 ASAC_0610 thiI thiI ASAC_0620 ASAC_0620 ASAC_0627 ASAC_0627 ASAC_0658 ASAC_0658 ASAC_0706 ASAC_0706 ASAC_0721 ASAC_0721 ASAC_0728 ASAC_0728 ASAC_0746 ASAC_0746 ASAC_0770 ASAC_0770 ASAC_0779 ASAC_0779 ASAC_0797 ASAC_0797 ASAC_0809 ASAC_0809 ribH ribH ASAC_0858 ASAC_0858 guaA guaA ASAC_0874 ASAC_0874 ASAC_0875 ASAC_0875 ASAC_0879 ASAC_0879 ASAC_1493 ASAC_1493 ASAC_1491 ASAC_1491 hisS hisS ASAC_1432 ASAC_1432 ASAC_1430 ASAC_1430 ASAC_1408 ASAC_1408 ASAC_1375 ASAC_1375 tyrS tyrS eif1a eif1a tmk tmk ASAC_1354 ASAC_1354 dnaG dnaG ASAC_1312 ASAC_1312 gatD gatD gatE gatE ASAC_1306 ASAC_1306 ASAC_1298 ASAC_1298 ASAC_1292 ASAC_1292 ASAC_1291 ASAC_1291 ASAC_1274 ASAC_1274 rpl2 rpl2 speE speE rps8e rps8e thiL thiL ASAC_1260 ASAC_1260 ASAC_1252 ASAC_1252 tfb tfb eif5a eif5a ASAC_1244 ASAC_1244 panB panB rpl10e rpl10e ASAC_1232 ASAC_1232 rpl15 rpl15 rpl30 rpl30 rps5 rps5 rpl18 rpl18 rpl19e rpl19e ASAC_1221 ASAC_1221 rpl6 rpl6 ASAC_1215 ASAC_1215 rps19e rps19e ASAC_1212 ASAC_1212 hemL hemL ASAC_1203 ASAC_1203 ASAC_1202 ASAC_1202 ASAC_1201 ASAC_1201 ASAC_1197 ASAC_1197 lig lig rps10 rps10 tuf tuf rps7 rps7 rps12 rps12 nusA nusA rpl30e rpl30e rpoA2 rpoA2 ASAC_1176 ASAC_1176 ASAC_1175 ASAC_1175 ASAC_1174 ASAC_1174 ASAC_1158 ASAC_1158 ASAC_1153 ASAC_1153 leuS leuS rpl24e rpl24e rpl37ae rpl37ae rpl15e rpl15e thyX thyX eif6 eif6 ASAC_1128 ASAC_1128 rpl39e rpl39e ASAC_1120 ASAC_1120 ASAC_1117 ASAC_1117 rpl18a rpl18a ASAC_1110 ASAC_1110 rpl40e rpl40e ASAC_1104 ASAC_1104 rps3ae rps3ae rps15 rps15 rps6e rps6e eif2g eif2g infB infB ndk ndk ASAC_1091 ASAC_1091 rps28e rps28e ASAC_1069 ASAC_1069 ASAC_1068 ASAC_1068 ASAC_1067 ASAC_1067 prs prs ASAC_1056 ASAC_1056 ASAC_1055 ASAC_1055 ASAC_1044 ASAC_1044 ribK ribK priL priL ASAC_1020 ASAC_1020 rpl7ae rpl7ae rps13 rps13 rps4 rps4 rps11 rps11 rpoD rpoD rpl18e rpl18e rpl13 rpl13 rps9 rps9 ASAC_1004 ASAC_1004 rps2 rps2 speH speH ASAC_0997 ASAC_0997 mtnP mtnP pth pth ASAC_0991 ASAC_0991 ASAC_0990 ASAC_0990 ASAC_0972 ASAC_0972 pyrE pyrE pyrB pyrB pyrI pyrI ASAC_0968 ASAC_0968 pyrD pyrD ASAC_0959 ASAC_0959 spt5 spt5 ASAC_0936 ASAC_0936 rpl4 rpl4 rpl23 rpl23 rpl37e rpl37e
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ASAC_0915PUA domain containing protein. (166 aa)
ASAC_0905DUF790 domain containing protein. (487 aa)
ASAC_0094Predicted GTPase. (349 aa)
ASAC_0096Pyruvate:ferredoxin oxidoreductase (POR) and putative 2-oxoglutarate:ferredoxin oxidoreductase (KGOR), gamma subunitubunit. (192 aa)
ASAC_0097Pyruvate:ferredoxin oxidoreductase (POR) and putative 2-oxoglutarate:ferredoxin oxidoreductase (KGOR), delta subunit. (112 aa)
lysSlysyl-tRNA synthetase (LysS); Belongs to the class-II aminoacyl-tRNA synthetase family. (498 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (409 aa)
ASAC_0104Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (338 aa)
ASAC_0106Putative nucleotidyl transferase. (387 aa)
ASAC_0111Predicted Fe-S oxidoreductase. (387 aa)
ASAC_0113Predicted Fe-S oxidoreductase. (390 aa)
ASAC_0114Siroheme synthase. (223 aa)
ASAC_0117Uridine phosphorylase. (281 aa)
cmkCytidylate kinase, putative. (185 aa)
ASAC_0130DNA polymerase 1. (975 aa)
glySGlycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). (583 aa)
ASAC_0139Hypothetical protein. (80 aa)
ASAC_0140Translation initiation factor Sui1; Belongs to the SUI1 family. (101 aa)
ASAC_0141Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Belongs to the UPF0284 family. (349 aa)
ASAC_0143Hypothetical protein. (171 aa)
cobSCobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (240 aa)
cobDProbable cobalamin biosynthesis protein cobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (313 aa)
ASAC_01506,7-dimethyl-8-ribityllumazine synthase. (148 aa)
ASAC_01513,4-dihydroxy-2-butanone 4-phosphate synthase. (228 aa)
ASAC_0155Acyl-CoA dehydrogenase. (399 aa)
ef1bElongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (88 aa)
ASAC_0171Predicted fibronectin-binding protein. (647 aa)
rpl14e50S ribosomal protein L14e; Belongs to the eukaryotic ribosomal protein eL14 family. (96 aa)
ASAC_0188Nicotinamide-nucleotide adenylyltransferase. (177 aa)
tbpTATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (207 aa)
priSProbable DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer sy [...] (357 aa)
rpl44e50S ribosomal protein L44E; Binds to the 23S rRNA. (95 aa)
ASAC_0203Translation initiation factor 2 subunit alpha. (269 aa)
adkAAdenylate kinase; Belongs to the archaeal adenylate kinase family. (209 aa)
rps830S ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rps1430S ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa)
rpl550S ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (188 aa)
rps4e30S ribosomal protein S4e; Belongs to the eukaryotic ribosomal protein eS4 family. (250 aa)
rpl2450S ribosomal protein L24P; Located at the polypeptide exit tunnel on the outside of the subunit. (136 aa)
rpl1450S ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (140 aa)
rps1730S ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa)
rpl2950S ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (86 aa)
rps330S ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (238 aa)
rpl2250S ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (159 aa)
rps19p30S ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (141 aa)
metGMethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. (576 aa)
cysSCysteinyl-tRNA synthetase. (476 aa)
rpl1150S ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (169 aa)
alaSAlanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (913 aa)
rpl12Hypothetical protein; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
rpl10LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (344 aa)
rpl150S ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (214 aa)
eif2bTranslation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (158 aa)
serSSeryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (459 aa)
ASAC_0272DUF137 domain containing protein. (266 aa)
ASAC_0273Hypothetical protein. (261 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (278 aa)
ASAC_0275Coenzyme A biosynthesis bifunctional protein CoaBC. (413 aa)
prf1Peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (403 aa)
ASAC_0280Nicotinamide-nucleotide adenylyltransferase. (170 aa)
ASAC_0285threonyl-tRNA synthetase. (467 aa)
ASAC_0287Valyl-tRNA synthetase. (821 aa)
tfeTranscription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing [...] (194 aa)
ASAC_0297Hypothetical protein. (203 aa)
rps17e30S ribosomal protein S17e; Belongs to the eukaryotic ribosomal protein eS17 family. (75 aa)
gltXGlutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (576 aa)
ASAC_0336Hypothetical protein. (272 aa)
ASAC_0337phenylalanyl-tRNA synthetase subunit beta. (558 aa)
pheSphenylalanyl-tRNA synthetase subunit alpha; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (481 aa)
argSArginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (633 aa)
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1061 aa)
ASAC_0365Threonyl/alanyl tRNA synthetase, SAD. (248 aa)
fusAElongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (731 aa)
proSProlyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (482 aa)
dcdProbable deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (183 aa)
nadKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (288 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (536 aa)
ASAC_0403Transcription elongation factor NusA-like protein. (196 aa)
ASAC_0410Asparaginyl-tRNA synthetase. (432 aa)
atpEV-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (199 aa)
atpAV-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (601 aa)
atpBV-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (467 aa)
ASAC_0421Probable uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (229 aa)
rpoKDNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (95 aa)
rpl21e50S ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family. (99 aa)
ASAC_0427DNA-directed RNA polymerase subunit F. (118 aa)
ASAC_0430Predicted ribonucleotide reductase, alpha subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (977 aa)
ASAC_0444Putative ATPase RIL. (601 aa)
ASAC_0455Putative DNA-directed RNA polymerase subunit M; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (117 aa)
aspSAspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). (464 aa)
ASAC_0465Hypothetical protein. (101 aa)
gatAGlutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (479 aa)
gatBAspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (485 aa)
ASAC_0474Hypothetical protein; Belongs to the eukaryotic ribosomal protein eL38 family. (135 aa)
ASAC_0481Competence damage-inducible protein A. (271 aa)
atpDV-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (223 aa)
ASAC_0502Putative translation initiation factor eIF-2B subunit; Belongs to the eIF-2B alpha/beta/delta subunits family. (294 aa)
trpSTryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). (373 aa)
ASAC_0526Predicted Fe-S oxidoreductase. (514 aa)
ASAC_0533Threonyl-tRNA synthetase. (468 aa)
ASAC_0539Acyl-CoA ligase (acyl-CoA synthetase). (639 aa)
ASAC_0552Putative transcription initiation factor IIB. (303 aa)
ASAC_0582Acyl-CoA dehydrogenase. (384 aa)
rps27ae30S ribosomal protein S27ae; Belongs to the eukaryotic ribosomal protein eS31 family. (60 aa)
rps24e30S ribosomal protein S24e; Belongs to the eukaryotic ribosomal protein eS24 family. (127 aa)
ASAC_0597Acyl-CoA ligase (acyl-CoA synthetase). (659 aa)
ASAC_0610Indolepyruvate:ferredoxin oxidoreductase (IOR), beta subunit. (201 aa)
thiIProbable thiamine biosynthesis protein thiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (375 aa)
ASAC_0620Hypothetical protein. (149 aa)
ASAC_0627Creatininase. (264 aa)
ASAC_0658dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (185 aa)
ASAC_0706Hypothetical protein. (223 aa)
ASAC_07215-formyltetrahydrofolate cyclo-ligase. (241 aa)
ASAC_0728Coproporphyrinogen III oxidase. (398 aa)
ASAC_0746Radical SAM domain protein. (167 aa)
ASAC_0770Probable deoxyuridine 5'-triphosphate nucleotidohydrolase. (160 aa)
ASAC_0779ATP:cobalamin adenosyltransferase. (170 aa)
ASAC_0797Glutamyl-tRNA amidotransferase, subunit A. (398 aa)
ASAC_0809ATP-NAD/AcoX kinase. (364 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa)
ASAC_0858Malate dehydrogenase. (473 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (517 aa)
ASAC_0874Putative 2-oxoacid:ferredoxin oxidoreductase, beta subunit. (304 aa)
ASAC_0875Putative 2-oxoacid:ferredoxin oxidoreductase, alpha subunit. (649 aa)
ASAC_0879Purine phosphoribosyltransferase. (232 aa)
ASAC_1493Creatinine amidohydrolase. (231 aa)
ASAC_1491Hypothetical protein. (101 aa)
hisSHistidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (432 aa)
ASAC_1432Probable uracil phosphoribosyltransferase. (211 aa)
ASAC_1430V-type ATP synthase subunit C. (342 aa)
ASAC_1408Radical SAM domain protein. (351 aa)
ASAC_1375Hydrolase domain containing protein. (234 aa)
tyrSTyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (358 aa)
eif1aTranslation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (110 aa)
tmkPutative thymidylate kinase. (214 aa)
ASAC_1354DNA polymerase 2. (802 aa)
dnaGHypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (439 aa)
ASAC_1312Hypothetical protein. (50 aa)
gatDGlutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (461 aa)
gatEGlutamyl-tRNA(Gln) amidotransferase subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (642 aa)
ASAC_1306Hypothetical protein. (183 aa)
ASAC_1298Heme biosynthesis protein. (386 aa)
ASAC_1292Putative 2-oxooglutarate:ferredoxin oxidoreductase (KGOR), beta subunit. (319 aa)
ASAC_1291Putative 2-oxoglutarate:ferredoxin oxidoreductase (KGOR), alpha subunit. (638 aa)
ASAC_1274Phosphomethylpyrimidine kinase. (462 aa)
rpl250S ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (237 aa)
speEProbable spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. (283 aa)
rps8e30S ribosomal protein S8e. (133 aa)
thiLPutative thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (293 aa)
ASAC_1260Acyl-CoA ligase (acyl-CoA synthetase). (656 aa)
ASAC_1252Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (756 aa)
tfbTranscription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (318 aa)
eif5aTranslation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (136 aa)
ASAC_1244Putative 2-dehydropantoate 2-reductase. (308 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (287 aa)
rpl10e50S ribosomal protein L10e; Belongs to the universal ribosomal protein uL16 family. (182 aa)
ASAC_1232Acyl-CoA dehydrogenase. (344 aa)
rpl1550S ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (166 aa)
rpl3050S ribosomal protein L30P. (157 aa)
rps530S ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (199 aa)
rpl1850S ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (212 aa)
rpl19e50S ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (156 aa)
ASAC_122150S ribosomal protein L32e. (135 aa)
rpl650S ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (182 aa)
ASAC_1215DUF115 domain containing protein. (236 aa)
rps19e30S ribosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (151 aa)
ASAC_1212Adenylate cyclase. (179 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (422 aa)
ASAC_1203Porphobilinogen deaminase. (298 aa)
ASAC_1202Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (256 aa)
ASAC_1201hemD uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (224 aa)
ASAC_1197DNA-directed RNA polymerase II subunit RPB11. (101 aa)
ligATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (607 aa)
rps1030S ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
tufElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (436 aa)
rps730S ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (203 aa)
rps1230S ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (145 aa)
nusATranscription elongation factor NusA-like protein; Participates in transcription termination. Belongs to the NusA family. (150 aa)
rpl30e50S ribosomal protein L30e; Belongs to the eukaryotic ribosomal protein eL30 family. (104 aa)
rpoA2DNA-directed RNA polymerase subunit A'; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (446 aa)
ASAC_1176DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (889 aa)
ASAC_1175DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1179 aa)
ASAC_1174DNA-directed RNA polymerase subunit H. (68 aa)
ASAC_1158Nicotinic acid phosphoribosyltransferase, putative. (402 aa)
ASAC_1153Pyrimidine nucleotide reductase. (215 aa)
leuSLeucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (962 aa)
rpl24e50S ribosomal protein L24e; Binds to the 23S rRNA. (63 aa)
rpl37ae50S ribosomal protein L37Ae; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily. (82 aa)
rpl15e50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. (227 aa)
thyXPredicted alternative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (333 aa)
eif6Translation initiation factor 6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (226 aa)
ASAC_1128Hypothetical protein. (78 aa)
rpl39eHypothetical protein; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
ASAC_1120Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (156 aa)
ASAC_1117Hypothetical protein. (281 aa)
rpl18a50S ribosomal protein LX. (88 aa)
ASAC_111030S ribosomal protein S26e. (95 aa)
rpl40e50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. (57 aa)
ASAC_1104Transcription elongation factor, S-II like-protein. (96 aa)
rps3ae30S ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family. (223 aa)
rps1530S ribosomal protein S15P/S13e. (152 aa)
rps6e30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family. (246 aa)
eif2gTranslation initiation factor 2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (424 aa)
infBProbable translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (609 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (141 aa)
ASAC_1091Putative nucleotidyl transferase. (412 aa)
rps28e30S ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family. (83 aa)
ASAC_1069TRNA-binding protein. (122 aa)
ASAC_1068DNA-directed RNA polymerase subunit E. (193 aa)
ASAC_1067Pur operon repressor-like protein. (220 aa)
prsPhosphoribosyl pyrophosphate synthase (PRPP synthase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (294 aa)
ASAC_10562-Ketoisovalerate:ferredoxin oxidoreductase (VOR), gamma subunit. (183 aa)
ASAC_10552-Ketoisovalerate:ferredoxin oxidoreductase (VOR), delta subunit. (87 aa)
ASAC_1044Hypothetical protein. (112 aa)
ribKHypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (152 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (341 aa)
ASAC_1020Selenocysteine-specific translation elongation factor-like protein. (304 aa)
rpl7ae50S ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (127 aa)
rps1330S ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (173 aa)
rps430S ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (177 aa)
rps1130S ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (131 aa)
rpoDDNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (287 aa)
rpl18eRibosomal protein L15; Belongs to the eukaryotic ribosomal protein eL18 family. (118 aa)
rpl1350S ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (156 aa)
rps930S ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (167 aa)
ASAC_1004DNA-directed RNA polymerase subunit N. (72 aa)
rps230S ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (239 aa)
speHS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (127 aa)
ASAC_0997Acyl-CoA ligase (acyl-CoA synthetase). (658 aa)
mtnP5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (282 aa)
pthPeptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (119 aa)
ASAC_0991Metal-dependent hydrolase of the beta-lactamase superfamily. (234 aa)
ASAC_0990S-adenosylmethionine decarboxylase related protein; Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (149 aa)
ASAC_0972Orotidine 5'-phosphate decarboxylase. (227 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (200 aa)
pyrBAspartate carbamoyltransferase. (314 aa)
pyrIAspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (157 aa)
ASAC_0968Dihydroorotase. (445 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (301 aa)
ASAC_0959Hexulose-6-phosphate synthase. (228 aa)
spt5Putative transcription antitermination protein nusG; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (172 aa)
ASAC_093650S ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (329 aa)
rpl450S ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (276 aa)
rpl2350S ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (88 aa)
rpl37e50S ribosomal protein L37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (62 aa)
Your Current Organism:
Acidilobus saccharovorans
NCBI taxonomy Id: 666510
Other names: A. saccharovorans 345-15, Acidilobus saccharovorans 345-15, Acidilobus saccharovorans str. 345-15, Acidilobus saccharovorans strain 345-15, Acidilobus sp. 345-15
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