STRINGSTRING
murA murA M301_0421 M301_0421 M301_0917 M301_0917 ftsB ftsB M301_1452 M301_1452 M301_1453 M301_1453 M301_1454 M301_1454 M301_1455 M301_1455 glmM glmM murI murI M301_2304 M301_2304 ftsZ ftsZ ftsA ftsA ftsQ ftsQ ddl ddl murB murB murC murC murG murG ftsW ftsW murD murD mraY mraY murF murF murE murE ftsI ftsI ftsL ftsL rsmH rsmH mraZ mraZ mtgA mtgA M301_2549 M301_2549 M301_2601 M301_2601 M301_2602 M301_2602 M301_2603 M301_2603 M301_2604 M301_2604 mrdA mrdA mrdB mrdB rlpA rlpA M301_2608 M301_2608 M301_2609 M301_2609 lipB lipB lipA lipA mpl mpl glmS glmS glmU glmU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa)
M301_0421TIGRFAM: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; KEGG: mmb:Mmol_0435 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; PFAM: peptidase S13 D-Ala-D-Ala carboxypeptidase C. (473 aa)
M301_0917KEGG: mmb:Mmol_0866 hypothetical protein. (364 aa)
ftsBSeptum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (136 aa)
M301_1452KEGG: cti:RALTA_A0761 cyanophycin synthetase; TIGRFAM: cyanophycin synthetase; PFAM: Mur ligase middle domain protein; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the MurCDEF family. (856 aa)
M301_1453TIGRFAM: cyanophycin synthetase; KEGG: cti:RALTA_A0762 cyanophycin synthetase; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Mur ligase middle domain protein. (720 aa)
M301_1454KEGG: reh:H16_A0776 ABC transporter ATPase/permease; PFAM: ABC transporter related; ABC transporter transmembrane region; SMART: AAA ATPase. (778 aa)
M301_1455PFAM: Domain of unknown function DUF1854; KEGG: dar:Daro_3263 hypothetical protein. (159 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (451 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (283 aa)
M301_2304PFAM: acyltransferase 3; KEGG: dar:Daro_0178 acyltransferase 3. (351 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (390 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (412 aa)
ftsQCell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (282 aa)
ddlD-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (312 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (299 aa)
murCUDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (472 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (357 aa)
ftsWCell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (387 aa)
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (452 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (367 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (464 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (488 aa)
ftsIPeptidoglycan glycosyltransferase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (586 aa)
ftsLCell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (108 aa)
rsmHS-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (316 aa)
mraZKEGG: mmb:Mmol_2013 MraZ protein; TIGRFAM: MraZ protein; PFAM: MraZ domain; Belongs to the MraZ family. (148 aa)
mtgAMonofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (244 aa)
M301_2549KEGG: mmb:Mmol_2137 rhodanese domain protein; PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein. (149 aa)
M301_2601KEGG: mmb:Mmol_2253 cell shape determining protein, MreB/Mrl family; TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl. (347 aa)
M301_2602Hypothetical protein. (46 aa)
M301_2603KEGG: mmb:Mmol_2254 rod shape-determining protein MreC; TIGRFAM: rod shape-determining protein MreC; PFAM: Rod shape-determining protein MreC. (361 aa)
M301_2604TIGRFAM: rod shape-determining protein MreD; KEGG: mmb:Mmol_2255 rod shape-determining protein MreD. (159 aa)
mrdAPenicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (651 aa)
mrdBRod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (364 aa)
rlpARare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (354 aa)
M301_2608Beta-lactamase; KEGG: mmb:Mmol_2259 beta-lactamase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; Belongs to the peptidase S11 family. (390 aa)
M301_2609PFAM: protein of unknown function DUF493; KEGG: mmb:Mmol_2260 protein of unknown function DUF493; Belongs to the UPF0250 family. (93 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (209 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (316 aa)
mplUDP-N-acetylmuramate; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (455 aa)
glmSGlucosamine/fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (610 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa)
Your Current Organism:
Methylotenera versatilis 301
NCBI taxonomy Id: 666681
Other names: M. versatilis 301, Methylotenera sp. 301, Methylotenera versatilis str. 301, Methylotenera versatilis strain 301
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.