(7 nodes) Mixed, incl. Proline biosynthesis, and Dynamin family network (Methylotenera versatilis 301)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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protein homology

Your Input:
	proB	Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (387 aa)
	proA	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (420 aa)
	M301_0642	KEGG: mmb:Mmol_0628 hypothetical protein. (690 aa)
	M301_0643	PFAM: protein of unknown function YGGT; KEGG: mmb:Mmol_0629 protein of unknown function YGGT. (195 aa)
	proC	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa)
	M301_0645	Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (240 aa)
	M301_2464	TIGRFAM: proline iminopeptidase; KEGG: mmb:Mmol_2050 proline iminopeptidase; PFAM: alpha/beta hydrolase fold; Belongs to the peptidase S33 family. (320 aa)

Your Current Organism:

Methylotenera versatilis 301

NCBI taxonomy Id: 666681
Other names: M. versatilis 301, Methylotenera sp. 301, Methylotenera versatilis str. 301, Methylotenera versatilis strain 301

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
M301_0642	M301_0643	M301_0642	M301_0643	KEGG: mmb:Mmol_0628 hypothetical protein.	PFAM: protein of unknown function YGGT; KEGG: mmb:Mmol_0629 protein of unknown function YGGT.	0.764
M301_0642	M301_0645	M301_0642	M301_0645	KEGG: mmb:Mmol_0628 hypothetical protein.	Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	0.640
M301_0642	proC	M301_0642	M301_0644	KEGG: mmb:Mmol_0628 hypothetical protein.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.764
M301_0643	M301_0642	M301_0643	M301_0642	PFAM: protein of unknown function YGGT; KEGG: mmb:Mmol_0629 protein of unknown function YGGT.	KEGG: mmb:Mmol_0628 hypothetical protein.	0.764
M301_0643	M301_0645	M301_0643	M301_0645	PFAM: protein of unknown function YGGT; KEGG: mmb:Mmol_0629 protein of unknown function YGGT.	Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	0.862
M301_0643	proC	M301_0643	M301_0644	PFAM: protein of unknown function YGGT; KEGG: mmb:Mmol_0629 protein of unknown function YGGT.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.825
M301_0645	M301_0642	M301_0645	M301_0642	Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	KEGG: mmb:Mmol_0628 hypothetical protein.	0.640
M301_0645	M301_0643	M301_0645	M301_0643	Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	PFAM: protein of unknown function YGGT; KEGG: mmb:Mmol_0629 protein of unknown function YGGT.	0.862
M301_0645	proC	M301_0645	M301_0644	Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.760
M301_2464	proC	M301_2464	M301_0644	TIGRFAM: proline iminopeptidase; KEGG: mmb:Mmol_2050 proline iminopeptidase; PFAM: alpha/beta hydrolase fold; Belongs to the peptidase S33 family.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.901
proA	proB	M301_0586	M301_0533	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	0.999
proA	proC	M301_0586	M301_0644	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.779
proB	proA	M301_0533	M301_0586	Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	0.999
proB	proC	M301_0533	M301_0644	Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.816
proC	M301_0642	M301_0644	M301_0642	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	KEGG: mmb:Mmol_0628 hypothetical protein.	0.764
proC	M301_0643	M301_0644	M301_0643	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	PFAM: protein of unknown function YGGT; KEGG: mmb:Mmol_0629 protein of unknown function YGGT.	0.825
proC	M301_0645	M301_0644	M301_0645	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	0.760
proC	M301_2464	M301_0644	M301_2464	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	TIGRFAM: proline iminopeptidase; KEGG: mmb:Mmol_2050 proline iminopeptidase; PFAM: alpha/beta hydrolase fold; Belongs to the peptidase S33 family.	0.901
proC	proA	M301_0644	M301_0586	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	0.779
proC	proB	M301_0644	M301_0533	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	0.816