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M301_0057 M301_0057 M301_0058 M301_0058 M301_0676 M301_0676 M301_0686 M301_0686 M301_0687 M301_0687 prpB prpB M301_0700 M301_0700 M301_0703 M301_0703 sucC sucC sucD sucD M301_1029 M301_1029 M301_1030 M301_1030 M301_1071 M301_1071 accD accD accA accA acsA acsA M301_1785 M301_1785
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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co-expression
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Your Input:
M301_0057acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa)
M301_0058acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (152 aa)
M301_0676KEGG: mmb:Mmol_0656 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; biotin/lipoyl attachment domain-containing protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (589 aa)
M301_0686TIGRFAM: 2-methylcitrate dehydratase; KEGG: mmb:Mmol_0748 2-methylcitrate dehydratase; PFAM: MmgE/PrpD family protein. (486 aa)
M301_0687TIGRFAM: 2-methylcitrate synthase/citrate synthase II; KEGG: mmb:Mmol_0749 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; Belongs to the citrate synthase family. (391 aa)
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (295 aa)
M301_0700PFAM: AMP-dependent synthetase and ligase; KEGG: mmb:Mmol_0763 AMP-dependent synthetase and ligase. (543 aa)
M301_0703KEGG: mmb:Mmol_0766 aconitate hydratase 2; TIGRFAM: aconitate hydratase 2; PFAM: Aconitase B; aconitate hydratase domain protein; Belongs to the aconitase/IPM isomerase family. (862 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
M301_1029KEGG: hna:Hneap_2368 methylmalonate-semialdehyde dehydrogenase; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. (500 aa)
M301_1030Beta-alanine--pyruvate transaminase; KEGG: hna:Hneap_2367 aminotransferase class-III; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (470 aa)
M301_1071KEGG: hna:Hneap_2371 4-aminobutyrate aminotransferase; TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (323 aa)
acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (662 aa)
M301_1785PFAM: aminotransferase class-III; KEGG: mei:Msip34_1203 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
Your Current Organism:
Methylotenera versatilis 301
NCBI taxonomy Id: 666681
Other names: M. versatilis 301, Methylotenera sp. 301, Methylotenera versatilis str. 301, Methylotenera versatilis strain 301
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