STRINGSTRING
AGK54007.1 AGK54007.1 AGK54095.1 AGK54095.1 AGK54100.1 AGK54100.1 AGK54142.1 AGK54142.1 AGK54166.1 AGK54166.1 AGK54216.1 AGK54216.1 AGK54314.1 AGK54314.1 AGK54333.1 AGK54333.1 AGK54334.1 AGK54334.1 AGK54336.1 AGK54336.1 AGK54414.1 AGK54414.1 AGK54416.1 AGK54416.1 AGK54563.1 AGK54563.1 ilvA ilvA AGK54604.1 AGK54604.1 AGK54676.1 AGK54676.1 hisC hisC lysA lysA AGK54816.1 AGK54816.1 AGK54817.1 AGK54817.1 dxs dxs AGK55583.1 AGK55583.1 AGK55779.1 AGK55779.1 AGK55913.1 AGK55913.1 AGK55927.1 AGK55927.1 glyA glyA icmF icmF AGK55476.1 AGK55476.1 AGK55453.1 AGK55453.1 AGK55450.1 AGK55450.1 rocD rocD AGK55318.1 AGK55318.1 AGK54869.1 AGK54869.1 menD menD AGK55251.1 AGK55251.1 AGK55121.1 AGK55121.1 hemL-2 hemL-2 AGK55034.1 AGK55034.1 AGK55008.1 AGK55008.1 alr alr AGK52176.1 AGK52176.1 AGK52224.1 AGK52224.1 bioA bioA AGK52438.1 AGK52438.1 hemL hemL AGK55493.1 AGK55493.1 AGK55499.1 AGK55499.1 AGK55581.1 AGK55581.1 serC serC AGK52627.1 AGK52627.1 AGK52656.1 AGK52656.1 argD argD AGK52807.1 AGK52807.1 AGK52822.1 AGK52822.1 AGK52884.1 AGK52884.1 AGK53000.1 AGK53000.1 AGK53036.1 AGK53036.1 AGK53129.1 AGK53129.1 AGK53473.1 AGK53473.1 AGK53481.1 AGK53481.1 AGK53566.1 AGK53566.1 AGK53692.1 AGK53692.1 AGK53826.1 AGK53826.1 AGK53865.1 AGK53865.1 AGK53980.1 AGK53980.1 AGK53982.1 AGK53982.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGK54007.1Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (529 aa)
AGK54095.1Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (797 aa)
AGK54100.1Transaminase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (388 aa)
AGK54142.1COG2258 Uncharacterized protein conserved in bacteria. (225 aa)
AGK54166.1COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs. (482 aa)
AGK54216.1COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs. (483 aa)
AGK54314.1Radical SAM domain-containing protein; COG1032 Fe-S oxidoreductase. (646 aa)
AGK54333.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (370 aa)
AGK54334.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (393 aa)
AGK54336.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1151 aa)
AGK54414.1Classes I and II aminotransferase; COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs. (404 aa)
AGK54416.1COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs. (462 aa)
AGK54563.1Hypothetical protein; COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (422 aa)
AGK54604.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (396 aa)
AGK54676.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (396 aa)
hisCCOG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (375 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (439 aa)
AGK54816.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (729 aa)
AGK54817.1COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (618 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (630 aa)
AGK55583.1Class I and II aminotransferase; COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (390 aa)
AGK55779.1Acetolactate synthase large subunit-like protein; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (566 aa)
AGK55913.1Spore coat biosynthesis protein; COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Belongs to the DegT/DnrJ/EryC1 family. (377 aa)
AGK55927.1UDP-bacillosamine synthetase; COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Belongs to the DegT/DnrJ/EryC1 family. (408 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
icmFmethylmalonyl-CoA mutase protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1088 aa)
AGK55476.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa)
AGK55453.1Class I and II aminotransferase; COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (389 aa)
AGK55450.1Hypothetical protein; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (395 aa)
rocDOrnithine--oxo-acid transaminase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (396 aa)
AGK55318.1Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (797 aa)
AGK54869.1Ribonucleotide-diphosphate reductase subunit alpha; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (853 aa)
menD2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (584 aa)
AGK55251.1COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (285 aa)
AGK55121.1COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (591 aa)
hemL-2COG0001 Glutamate-1-semialdehyde aminotransferase. (429 aa)
AGK55034.1COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (381 aa)
AGK55008.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (377 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (395 aa)
AGK52176.1Threonine-phosphate decarboxylase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (370 aa)
AGK52224.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (378 aa)
bioAAdenosylmethionine--8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (446 aa)
AGK52438.1Hypothetical protein; COG4032 Predicted thiamine-pyrophosphate-binding protein. (376 aa)
hemLCOG0001 Glutamate-1-semialdehyde aminotransferase. (431 aa)
AGK55493.1Cysteine desulfurase SufS; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (409 aa)
AGK55499.1COG2873 O-acetylhomoserine sulfhydrylase. (407 aa)
AGK55581.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (390 aa)
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (361 aa)
AGK52627.1D-alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (393 aa)
AGK52656.1DegT/DnrJ/EryC1/StrS aminotransferase; COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Belongs to the DegT/DnrJ/EryC1 family. (386 aa)
argDCOG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (387 aa)
AGK52807.1Cobalamin B12-binding domain-containing protein; COG1032 Fe-S oxidoreductase. (582 aa)
AGK52822.1Pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. (769 aa)
AGK52884.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (384 aa)
AGK53000.1Hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (229 aa)
AGK53036.1COG1564 Thiamine pyrophosphokinase. (214 aa)
AGK53129.1COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (288 aa)
AGK53473.1Aminotransferase; COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
AGK53481.1Aminotransferase; COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa)
AGK53566.18-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (389 aa)
AGK53692.1COG2873 O-acetylhomoserine sulfhydrylase. (437 aa)
AGK53826.1Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (400 aa)
AGK53865.12-amino-3-ketobutyrate coenzyme A ligase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. (396 aa)
AGK53980.1COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (378 aa)
AGK53982.1Aminotransferase; COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa)
Your Current Organism:
Bacillus sp. 1NLA3E
NCBI taxonomy Id: 666686
Other names: B. sp. 1NLA3E
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.