(47 nodes) Regulation of macroautophagy network (Daphnia pulex)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	E9GDJ8_DAPPU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
	E9GB97_DAPPU	Lipid_DES domain-containing protein; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (322 aa)
	E9GAH4_DAPPU	Uncharacterized protein. (802 aa)
	E9GA07_DAPPU	UDENN FLCN/SMCR8-type domain-containing protein. (246 aa)
	E9G440_DAPPU	Uncharacterized protein. (587 aa)
	E9G304_DAPPU	Uncharacterized protein. (129 aa)
	E9G2W8_DAPPU	Uncharacterized protein. (214 aa)
	E9G1K5_DAPPU	PX domain-containing protein. (441 aa)
	E9G0L1_DAPPU	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (481 aa)
	E9FYT8_DAPPU	Non-specific serine/threonine protein kinase. (540 aa)
	E9FXX4_DAPPU	Uncharacterized protein. (224 aa)
	E9FXN7_DAPPU	BHLH domain-containing protein. (105 aa)
	E9FT35_DAPPU	Uncharacterized protein. (2037 aa)
	E9FS10_DAPPU	USP domain-containing protein. (447 aa)
	E9I2R2_DAPPU	USP domain-containing protein. (194 aa)
	E9HZS6_DAPPU	Uncharacterized protein. (300 aa)
	E9HVM8_DAPPU	FAT domain-containing protein. (56 aa)
	E9HPX5_DAPPU	Uncharacterized protein. (387 aa)
	E9HM64_DAPPU	Uncharacterized protein. (199 aa)
	E9HJ39_DAPPU	Aminotran_1_2 domain-containing protein. (247 aa)
	TSC2	Putative tuberous sclerosis 2 isoform 3-like protein. (1640 aa)
	E9HGK8_DAPPU	NPL domain-containing protein. (372 aa)
	TOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2517 aa)
	E9HBY6_DAPPU	Uncharacterized protein. (381 aa)
	E9HBY5_DAPPU	Uncharacterized protein. (136 aa)
	EOG090X0BB3	Autophagy protein 5; Involved in autophagic vesicle formation. (271 aa)
	E9H8J2_DAPPU	SAC domain-containing protein. (1150 aa)
	E9H824_DAPPU	PX domain-containing protein. (439 aa)
	E9H5P4_DAPPU	Uncharacterized protein. (399 aa)
	E9H4C1_DAPPU	UBIQUITIN_CONJUGAT_2 domain-containing protein. (448 aa)
	E9H292_DAPPU	Uncharacterized protein. (467 aa)
	E9H165_DAPPU	Uncharacterized protein. (262 aa)
	E9GXX5_DAPPU	WD_REPEATS_REGION domain-containing protein. (58 aa)
	E9GUW8_DAPPU	Uncharacterized protein. (526 aa)
	E9GU71_DAPPU	Uncharacterized protein. (2402 aa)
	E9GU15_DAPPU	Uncharacterized protein. (213 aa)
	E9GTR2_DAPPU	PHD domain-containing protein. (164 aa)
	E9GT52_DAPPU	Protein kinase domain-containing protein. (57 aa)
	Rheb	Uncharacterized protein Rheb. (185 aa)
	E9GR34_DAPPU	Rab-GAP TBC domain-containing protein. (626 aa)
	E9GPZ4_DAPPU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (453 aa)
	E9GN97_DAPPU	WD_REPEATS_REGION domain-containing protein. (728 aa)
	E9GL53_DAPPU	FPL domain-containing protein. (773 aa)
	E9GJ68_DAPPU	Uncharacterized protein. (1070 aa)
	E9GGE6_DAPPU	FK506-binding protein. (361 aa)
	E9GG69_DAPPU	Uncharacterized protein. (4191 aa)
	E9GCT9_DAPPU	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (704 aa)

Your Current Organism:

Daphnia pulex

NCBI taxonomy Id: 6669
Other names: D. pulex, common water flea

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E9FT35_DAPPU	E9GU15_DAPPU	E9FT35	E9GU15	Uncharacterized protein.	Uncharacterized protein.	0.739
E9FXX4_DAPPU	E9FYT8_DAPPU	E9FXX4	E9FYT8	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.614
E9FXX4_DAPPU	E9G440_DAPPU	E9FXX4	E9G440	Uncharacterized protein.	Uncharacterized protein.	0.546
E9FXX4_DAPPU	E9GA07_DAPPU	E9FXX4	E9GA07	Uncharacterized protein.	UDENN FLCN/SMCR8-type domain-containing protein.	0.433
E9FXX4_DAPPU	E9GCT9_DAPPU	E9FXX4	E9GCT9	Uncharacterized protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	0.702
E9FXX4_DAPPU	E9GDJ8_DAPPU	E9FXX4	E9GDJ8	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.927
E9FXX4_DAPPU	E9GT52_DAPPU	E9FXX4	E9GT52	Uncharacterized protein.	Protein kinase domain-containing protein.	0.614
E9FXX4_DAPPU	E9GXX5_DAPPU	E9FXX4	E9GXX5	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.546
E9FXX4_DAPPU	E9H165_DAPPU	E9FXX4	E9H165	Uncharacterized protein.	Uncharacterized protein.	0.546
E9FXX4_DAPPU	E9HM64_DAPPU	E9FXX4	E9HM64	Uncharacterized protein.	Uncharacterized protein.	0.546
E9FXX4_DAPPU	E9HVM8_DAPPU	E9FXX4	E9HVM8	Uncharacterized protein.	FAT domain-containing protein.	0.726
E9FXX4_DAPPU	E9HZS6_DAPPU	E9FXX4	E9HZS6	Uncharacterized protein.	Uncharacterized protein.	0.546
E9FXX4_DAPPU	EOG090X0BB3	E9FXX4	E9H8N6	Uncharacterized protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.718
E9FXX4_DAPPU	Rheb	E9FXX4	E9GRL7	Uncharacterized protein.	Uncharacterized protein Rheb.	0.771
E9FXX4_DAPPU	TOR	E9FXX4	E9HG28	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.971
E9FYT8_DAPPU	E9FXX4_DAPPU	E9FYT8	E9FXX4	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.614
E9FYT8_DAPPU	E9GDJ8_DAPPU	E9FYT8	E9GDJ8	Non-specific serine/threonine protein kinase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.520
E9FYT8_DAPPU	E9H5P4_DAPPU	E9FYT8	E9H5P4	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.640
E9FYT8_DAPPU	E9HVM8_DAPPU	E9FYT8	E9HVM8	Non-specific serine/threonine protein kinase.	FAT domain-containing protein.	0.669
E9FYT8_DAPPU	Rheb	E9FYT8	E9GRL7	Non-specific serine/threonine protein kinase.	Uncharacterized protein Rheb.	0.708