(98 nodes) Negative regulation of MAPK cascade network (Daphnia pulex)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	E9GB43_DAPPU	Uncharacterized protein. (99 aa)
	E9FRE8_DAPPU	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	E9FRH9_DAPPU	Uncharacterized protein. (466 aa)
	E9FSK2_DAPPU	Uncharacterized protein. (800 aa)
	E9FVQ8_DAPPU	Uncharacterized protein. (2092 aa)
	E9FYR7_DAPPU	Uncharacterized protein. (317 aa)
	E9G0L1_DAPPU	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (481 aa)
	E9G1G8_DAPPU	Uncharacterized protein. (279 aa)
	E9G1N9_DAPPU	Uncharacterized protein. (306 aa)
	E9G229_DAPPU	Uncharacterized protein. (4373 aa)
	E9G2F4_DAPPU	WD_REPEATS_REGION domain-containing protein. (684 aa)
	E9G2R4_DAPPU	Uncharacterized protein. (495 aa)
	E9G411_DAPPU	WD_REPEATS_REGION domain-containing protein. (558 aa)
	E9G4G4_DAPPU	WD_REPEATS_REGION domain-containing protein. (381 aa)
	E9G4G8_DAPPU	Uncharacterized protein. (443 aa)
	E9G4H4_DAPPU	Uncharacterized protein. (420 aa)
	E9G4Y5_DAPPU	WD_REPEATS_REGION domain-containing protein. (403 aa)
	E9G504_DAPPU	Uncharacterized protein. (395 aa)
	HNT	Hindsight transcription factor-like protein. (1531 aa)
	E9G5A7_DAPPU	WD_REPEATS_REGION domain-containing protein. (329 aa)
	E9G7E4_DAPPU	WH1 domain-containing protein. (481 aa)
	E9G7V0_DAPPU	WD_REPEATS_REGION domain-containing protein. (822 aa)
	E9G881_DAPPU	Uncharacterized protein. (446 aa)
	E9GBI2_DAPPU	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (228 aa)
	E9GCU8_DAPPU	LIM domain-containing protein. (342 aa)
	E9GCU9_DAPPU	SAC domain-containing protein. (588 aa)
	E9GCW9_DAPPU	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (245 aa)
	E9GD92_DAPPU	Uncharacterized protein. (284 aa)
	E9GDE4_DAPPU	Uncharacterized protein. (290 aa)
	E9GEM8_DAPPU	Uncharacterized protein. (805 aa)
	E9GG02_DAPPU	Serine/threonine-protein phosphatase. (304 aa)
	E9GG71_DAPPU	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (149 aa)
	E9GGY3_DAPPU	WD_REPEATS_REGION domain-containing protein. (73 aa)
	E9GI14_DAPPU	WD_REPEATS_REGION domain-containing protein. (378 aa)
	E9GI91_DAPPU	Uncharacterized protein. (487 aa)
	EOG090X098Y	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (275 aa)
	E9GM58_DAPPU	Uncharacterized protein. (298 aa)
	S6K	Ribosomal protein S6 kinase. (730 aa)
	E9GPC8_DAPPU	WD_REPEATS_REGION domain-containing protein. (221 aa)
	E9GPD1_DAPPU	Uncharacterized protein. (51 aa)
	E9GPD2_DAPPU	Uncharacterized protein. (149 aa)
	E9GQ20_DAPPU	WD_REPEATS_REGION domain-containing protein. (209 aa)
	E9GR06_DAPPU	Uncharacterized protein. (122 aa)
	E9GR17_DAPPU	Uncharacterized protein. (122 aa)
	E9GR18_DAPPU	Uncharacterized protein. (291 aa)
	E9GR19_DAPPU	Uncharacterized protein. (112 aa)
	E9GRQ2_DAPPU	Uncharacterized protein. (67 aa)
	E9GRQ3_DAPPU	WD_REPEATS_REGION domain-containing protein. (211 aa)
	E9GWT5_DAPPU	Uncharacterized protein. (163 aa)
	E9GWT6_DAPPU	Uncharacterized protein. (64 aa)
	E9GWT7_DAPPU	HECT domain-containing protein. (76 aa)
	E9GWV2_DAPPU	HECT domain-containing protein. (87 aa)
	E9GXU4_DAPPU	N-acetyltransferase domain-containing protein. (200 aa)
	E9GY66_DAPPU	Uncharacterized protein. (330 aa)
	E9GYS1_DAPPU	Uncharacterized protein. (138 aa)
	E9H065_DAPPU	Uncharacterized protein. (70 aa)
	E9H1E9_DAPPU	Uncharacterized protein. (83 aa)
	E9H2M5_DAPPU	Uncharacterized protein. (141 aa)
	E9H331_DAPPU	Uncharacterized protein. (150 aa)
	E9H332_DAPPU	Uncharacterized protein. (158 aa)
	E9H334_DAPPU	Uncharacterized protein. (88 aa)
	E9H335_DAPPU	Uncharacterized protein. (145 aa)
	E9H3F1_DAPPU	UBR-type domain-containing protein. (5084 aa)
	E9H4K6_DAPPU	PPM-type phosphatase domain-containing protein. (379 aa)
	E9H5G9_DAPPU	Phosphoinositide phospholipase C. (616 aa)
	E9H5M7_DAPPU	Uncharacterized protein. (87 aa)
	E9H5M8_DAPPU	WD_REPEATS_REGION domain-containing protein. (206 aa)
	E9H6T7_DAPPU	Ubiquitinyl hydrolase 1. (668 aa)
	E9H6T8_DAPPU	USP domain-containing protein; Belongs to the peptidase C19 family. (111 aa)
	E9H6T9_DAPPU	Uncharacterized protein. (271 aa)
	E9HAB6_DAPPU	Uncharacterized protein. (751 aa)
	E9HAP0_DAPPU	JmjC domain-containing protein. (400 aa)
	E9HCJ6_DAPPU	Chromo domain-containing protein. (101 aa)
	E9HDD2_DAPPU	Uncharacterized protein. (142 aa)
	E9HFM3_DAPPU	Uncharacterized protein. (88 aa)
	E9HFP7_DAPPU	WD_REPEATS_REGION domain-containing protein. (200 aa)
	E9HFZ3_DAPPU	WD_REPEATS_REGION domain-containing protein. (106 aa)
	E9HFZ4_DAPPU	Uncharacterized protein. (74 aa)
	E9HH02_DAPPU	Uncharacterized protein. (73 aa)
	E9HI67_DAPPU	Uncharacterized protein. (296 aa)
	E9HIK6_DAPPU	Uncharacterized protein. (298 aa)
	E9HJE5_DAPPU	WD_REPEATS_REGION domain-containing protein. (73 aa)
	EOG090X08VX	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	E9HLA9_DAPPU	Uncharacterized protein. (2758 aa)
	E9HQV9_DAPPU	Uncharacterized protein. (611 aa)
	E9HS90_DAPPU	Uncharacterized protein. (98 aa)
	E9HS91_DAPPU	Uncharacterized protein. (50 aa)
	E9HUZ3_DAPPU	Uncharacterized protein. (147 aa)
	E9HV83_DAPPU	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (172 aa)
	E9HVL2_DAPPU	Uncharacterized protein. (129 aa)
	E9HXQ7_DAPPU	Phosphoinositide phospholipase C. (1050 aa)
	E9I0H0_DAPPU	Uncharacterized protein. (170 aa)
	E9I0K6_DAPPU	WD_REPEATS_REGION domain-containing protein. (97 aa)
	E9I148_DAPPU	Uncharacterized protein. (67 aa)
	E9I1V0_DAPPU	WD_REPEATS_REGION domain-containing protein. (90 aa)
	E9I226_DAPPU	WD_REPEATS_REGION domain-containing protein. (162 aa)
	E9I7B1_DAPPU	JmjC domain-containing protein. (130 aa)
	E9I7P0_DAPPU	Uncharacterized protein. (64 aa)

Your Current Organism:

Daphnia pulex

NCBI taxonomy Id: 6669
Other names: D. pulex, common water flea

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E9FRE8_DAPPU	E9G0L1_DAPPU	E9FRE8	E9G0L1	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.529
E9FRE8_DAPPU	E9G229_DAPPU	E9FRE8	E9G229	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.452
E9FRE8_DAPPU	E9HCJ6_DAPPU	E9FRE8	E9HCJ6	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Chromo domain-containing protein.	0.452
E9FRH9_DAPPU	E9G7E4_DAPPU	E9FRH9	E9G7E4	Uncharacterized protein.	WH1 domain-containing protein.	0.449
E9FRH9_DAPPU	E9GG02_DAPPU	E9FRH9	E9GG02	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.535
E9FRH9_DAPPU	E9GY66_DAPPU	E9FRH9	E9GY66	Uncharacterized protein.	Uncharacterized protein.	0.417
E9FSK2_DAPPU	E9GG02_DAPPU	E9FSK2	E9GG02	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.991
E9FVQ8_DAPPU	E9GBI2_DAPPU	E9FVQ8	E9GBI2	Uncharacterized protein.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.514
E9FVQ8_DAPPU	E9GCU9_DAPPU	E9FVQ8	E9GCU9	Uncharacterized protein.	SAC domain-containing protein.	0.718
E9FVQ8_DAPPU	E9GD92_DAPPU	E9FVQ8	E9GD92	Uncharacterized protein.	Uncharacterized protein.	0.516
E9FVQ8_DAPPU	E9GDE4_DAPPU	E9FVQ8	E9GDE4	Uncharacterized protein.	Uncharacterized protein.	0.511
E9FVQ8_DAPPU	E9GM58_DAPPU	E9FVQ8	E9GM58	Uncharacterized protein.	Uncharacterized protein.	0.516
E9FVQ8_DAPPU	E9GY66_DAPPU	E9FVQ8	E9GY66	Uncharacterized protein.	Uncharacterized protein.	0.557
E9FVQ8_DAPPU	E9HVL2_DAPPU	E9FVQ8	E9HVL2	Uncharacterized protein.	Uncharacterized protein.	0.516
E9G0L1_DAPPU	E9FRE8_DAPPU	E9G0L1	E9FRE8	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.529
E9G229_DAPPU	E9FRE8_DAPPU	E9G229	E9FRE8	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.452
E9G2F4_DAPPU	E9GEM8_DAPPU	E9G2F4	E9GEM8	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.915
E9G2R4_DAPPU	E9H5G9_DAPPU	E9G2R4	E9H5G9	Uncharacterized protein.	Phosphoinositide phospholipase C.	0.772
E9G504_DAPPU	E9HFP7_DAPPU	E9G504	E9HFP7	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.403
E9G7E4_DAPPU	E9FRH9_DAPPU	E9G7E4	E9FRH9	WH1 domain-containing protein.	Uncharacterized protein.	0.449