(78 nodes) Regulation of cellular response to growth factor stimulus network (Daphnia pulex)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	E9GCW9_DAPPU	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (245 aa)
	E9FR25_DAPPU	Uncharacterized protein. (936 aa)
	E9FR26_DAPPU	Uncharacterized protein. (1945 aa)
	E9FR27_DAPPU	Uncharacterized protein. (819 aa)
	E9FRC7_DAPPU	Tyrosine-protein phosphatase domain-containing protein. (216 aa)
	E9FRH9_DAPPU	Uncharacterized protein. (466 aa)
	E9FS72_DAPPU	CTCK domain-containing protein. (163 aa)
	E9FU10_DAPPU	MSC domain-containing protein. (250 aa)
	E9FV93_DAPPU	PAW domain-containing protein. (465 aa)
	E9FVQ8_DAPPU	Uncharacterized protein. (2092 aa)
	E9FW43_DAPPU	ZP domain-containing protein. (948 aa)
	TSC-1	Tuber sclerosis 1-like protein. (262 aa)
	E9FYV0_DAPPU	DEP domain-containing protein. (861 aa)
	E9G1G8_DAPPU	Uncharacterized protein. (279 aa)
	E9G204_DAPPU	Uncharacterized protein. (270 aa)
	E9G205_DAPPU	Death domain-containing protein. (395 aa)
	E9G782_DAPPU	Uncharacterized protein. (432 aa)
	E9G7A2_DAPPU	Uncharacterized protein. (558 aa)
	E9G8C7_DAPPU	HECT domain-containing protein. (882 aa)
	E9G991_DAPPU	Uncharacterized protein. (457 aa)
	E9G9U9_DAPPU	VWFC domain-containing protein. (474 aa)
	E9G9V0_DAPPU	VWFC domain-containing protein. (317 aa)
	E9G9V5_DAPPU	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (208 aa)
	E9GA59_DAPPU	Uncharacterized protein; Belongs to the DEAD box helicase family. (429 aa)
	E9GBY9_DAPPU	RING-type domain-containing protein. (258 aa)
	E9GBZ0_DAPPU	Uncharacterized protein. (394 aa)
	E9GFJ0_DAPPU	FCP1 homology domain-containing protein. (237 aa)
	E9GG71_DAPPU	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (149 aa)
	E9GGF5_DAPPU	c-SKI_SMAD_bind domain-containing protein. (210 aa)
	E9GHT7_DAPPU	UDENN FLCN/SMCR8-type domain-containing protein. (355 aa)
	E9GI11_DAPPU	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
	E9GIQ7_DAPPU	E3 ubiquitin-protein ligase. (805 aa)
	E9GL75_DAPPU	c-SKI_SMAD_bind domain-containing protein. (255 aa)
	E9GN61_DAPPU	Ras-associating domain-containing protein. (238 aa)
	E9GT87_DAPPU	Uncharacterized protein. (242 aa)
	E9GTW0_DAPPU	HECT domain-containing protein. (634 aa)
	E9GU23_DAPPU	Uncharacterized protein. (1417 aa)
	E9GU44_DAPPU	LNS2 domain-containing protein. (1037 aa)
	E9GVM2_DAPPU	Uncharacterized protein. (254 aa)
	E9GVS2_DAPPU	ENTH domain-containing protein. (152 aa)
	E9GW38_DAPPU	ZnMc domain-containing protein. (637 aa)
	E9GX89_DAPPU	DEP domain-containing protein. (914 aa)
	E9GZ07_DAPPU	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (546 aa)
	E9H0Q1_DAPPU	Uncharacterized protein. (163 aa)
	E9H0Z0_DAPPU	TPR_REGION domain-containing protein. (1043 aa)
	E9H1F7_DAPPU	Uncharacterized protein. (368 aa)
	E9H1S2_DAPPU	Uncharacterized protein. (4703 aa)
	E9H6B8_DAPPU	MFS domain-containing protein. (526 aa)
	E9H6B9_DAPPU	MFS domain-containing protein. (490 aa)
	E9H6C0_DAPPU	MFS domain-containing protein. (554 aa)
	E9H6C1_DAPPU	MFS domain-containing protein. (426 aa)
	E9H7W9_DAPPU	COesterase domain-containing protein. (679 aa)
	E9H834_DAPPU	RBM39linker domain-containing protein. (202 aa)
	E9H8M6_DAPPU	MH2 domain-containing protein. (190 aa)
	E9H8R7_DAPPU	Uncharacterized protein; Belongs to the LIMR family. (471 aa)
	E9HAB9_DAPPU	CULLIN_2 domain-containing protein; Belongs to the cullin family. (697 aa)
	E9HBL1_DAPPU	Uncharacterized protein. (854 aa)
	E9HBP0_DAPPU	Uncharacterized protein. (266 aa)
	E9HCS5_DAPPU	Uncharacterized protein. (308 aa)
	E9HCW8_DAPPU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (273 aa)
	E9HF04_DAPPU	Uncharacterized protein. (175 aa)
	TSC2	Putative tuberous sclerosis 2 isoform 3-like protein. (1640 aa)
	E9HIY7_DAPPU	Uncharacterized protein. (262 aa)
	E9HJ08_DAPPU	Uncharacterized protein. (1160 aa)
	E9HMB1_DAPPU	Uncharacterized protein. (584 aa)
	E9HNV0_DAPPU	Uncharacterized protein. (679 aa)
	E9HNW1_DAPPU	Uncharacterized protein. (545 aa)
	E9HPX6_DAPPU	Uncharacterized protein. (537 aa)
	E9HQF4_DAPPU	Uncharacterized protein. (176 aa)
	E9HQF5_DAPPU	Metalloendopeptidase. (909 aa)
	E9HR66_DAPPU	Protein kinase domain-containing protein. (931 aa)
	E9HST2_DAPPU	Uncharacterized protein. (749 aa)
	E9HST3_DAPPU	VWFC domain-containing protein. (73 aa)
	E9HUA7_DAPPU	Uncharacterized protein. (305 aa)
	E9HUA8_DAPPU	MFS domain-containing protein. (260 aa)
	E9HV83_DAPPU	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (172 aa)
	E9I4M4_DAPPU	AZUL domain-containing protein. (112 aa)
	E9I5D1_DAPPU	CUB domain-containing protein. (107 aa)

Your Current Organism:

Daphnia pulex

NCBI taxonomy Id: 6669
Other names: D. pulex, common water flea

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E9FR25_DAPPU	E9GI11_DAPPU	E9FR25	E9GI11	Uncharacterized protein.	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.416
E9FR26_DAPPU	E9FR27_DAPPU	E9FR26	E9FR27	Uncharacterized protein.	Uncharacterized protein.	0.840
E9FR26_DAPPU	E9GI11_DAPPU	E9FR26	E9GI11	Uncharacterized protein.	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.416
E9FR27_DAPPU	E9FR26_DAPPU	E9FR27	E9FR26	Uncharacterized protein.	Uncharacterized protein.	0.840
E9FR27_DAPPU	E9GI11_DAPPU	E9FR27	E9GI11	Uncharacterized protein.	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.416
E9FRH9_DAPPU	E9H8R7_DAPPU	E9FRH9	E9H8R7	Uncharacterized protein.	Uncharacterized protein; Belongs to the LIMR family.	0.438
E9FS72_DAPPU	E9GVM2_DAPPU	E9FS72	E9GVM2	CTCK domain-containing protein.	Uncharacterized protein.	0.619
E9FU10_DAPPU	E9H8M6_DAPPU	E9FU10	E9H8M6	MSC domain-containing protein.	MH2 domain-containing protein.	0.531
E9FVQ8_DAPPU	E9G204_DAPPU	E9FVQ8	E9G204	Uncharacterized protein.	Uncharacterized protein.	0.441
E9FVQ8_DAPPU	E9G205_DAPPU	E9FVQ8	E9G205	Uncharacterized protein.	Death domain-containing protein.	0.441
E9G204_DAPPU	E9FVQ8_DAPPU	E9G204	E9FVQ8	Uncharacterized protein.	Uncharacterized protein.	0.441
E9G205_DAPPU	E9FVQ8_DAPPU	E9G205	E9FVQ8	Death domain-containing protein.	Uncharacterized protein.	0.441
E9G9V5_DAPPU	E9GI11_DAPPU	E9G9V5	E9GI11	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.648
E9GBY9_DAPPU	E9GBZ0_DAPPU	E9GBY9	E9GBZ0	RING-type domain-containing protein.	Uncharacterized protein.	0.799
E9GBZ0_DAPPU	E9GBY9_DAPPU	E9GBZ0	E9GBY9	Uncharacterized protein.	RING-type domain-containing protein.	0.799
E9GCW9_DAPPU	E9GG71_DAPPU	E9GCW9	E9GG71	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.953
E9GCW9_DAPPU	E9HV83_DAPPU	E9GCW9	E9HV83	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.954
E9GFJ0_DAPPU	E9GU44_DAPPU	E9GFJ0	E9GU44	FCP1 homology domain-containing protein.	LNS2 domain-containing protein.	0.810
E9GG71_DAPPU	E9GCW9_DAPPU	E9GG71	E9GCW9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.953
E9GG71_DAPPU	E9HV83_DAPPU	E9GG71	E9HV83	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.905