(45 nodes) Regulation of cysteine-type endopeptidase activity network (Daphnia pulex)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	E9HD18_DAPPU	CULLIN_2 domain-containing protein; Belongs to the cullin family. (757 aa)
	E9G204_DAPPU	Uncharacterized protein. (270 aa)
	E9G205_DAPPU	Death domain-containing protein. (395 aa)
	E9G2H2_DAPPU	Uncharacterized protein. (202 aa)
	EOG090X0GLS	EOG090X0GLS. (187 aa)
	E9G4N7_DAPPU	Uncharacterized protein; Belongs to the protein kinase superfamily. (467 aa)
	E9G767_DAPPU	Uncharacterized protein. (556 aa)
	E9GA73_DAPPU	FAD-binding PCMH-type domain-containing protein. (505 aa)
	E9GDU6_DAPPU	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (798 aa)
	E9GEM2_DAPPU	GRAM domain-containing protein. (569 aa)
	E9GI23_DAPPU	Uncharacterized protein. (493 aa)
	E9GIN9_DAPPU	Uncharacterized protein. (474 aa)
	MYC	Myc, dMyc-like protein. (99 aa)
	E9GNE9_DAPPU	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (450 aa)
	E9GPY9_DAPPU	Protein kinase domain-containing protein. (149 aa)
	E9GTR4_DAPPU	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (146 aa)
	E9GV13_DAPPU	Uncharacterized protein. (402 aa)
	E9GV21_DAPPU	Uncharacterized protein. (132 aa)
	E9GV57_DAPPU	Uncharacterized protein. (141 aa)
	E9H0N0_DAPPU	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (126 aa)
	E9H5Q6_DAPPU	Uncharacterized protein. (225 aa)
	E9H668_DAPPU	PIH1 domain-containing protein. (318 aa)
	E9HUJ5_DAPPU	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (450 aa)
	E9HTW1_DAPPU	Protein kinase domain-containing protein. (371 aa)
	E9HS84_DAPPU	RING-type domain-containing protein. (114 aa)
	E9HS82_DAPPU	RING-type domain-containing protein. (114 aa)
	E9HS16_DAPPU	Protein kinase domain-containing protein. (353 aa)
	E9HRZ7_DAPPU	Protein kinase domain-containing protein. (171 aa)
	E9HP27_DAPPU	RING-type domain-containing protein. (395 aa)
	E9HIJ4_DAPPU	Uncharacterized protein. (90 aa)
	E9HFS7_DAPPU	Uncharacterized protein. (421 aa)
	E9HEP5_DAPPU	Uncharacterized protein; Belongs to the peptidase C14A family. (263 aa)
	E9HAS1_DAPPU	RING-type domain-containing protein. (109 aa)
	E9HAH1_DAPPU	Uncharacterized protein; Belongs to the peptidase C14A family. (245 aa)
	E9HA22_DAPPU	PRA1 family protein. (186 aa)
	E9H8T6_DAPPU	Putative vasopressin-like neuropeptide preprohormone. (137 aa)
	C7DR07_DAPPU	FAD-binding PCMH-type domain-containing protein. (524 aa)
	DHC24	24-dehydrocholesterol reductase. (521 aa)
	E9FR55_DAPPU	Uncharacterized protein; Belongs to the cystatin family. (242 aa)
	E9FR56_DAPPU	Uncharacterized protein. (227 aa)
	E9FRG0_DAPPU	Protein kinase domain-containing protein. (742 aa)
	E9FSM2_DAPPU	RING-type domain-containing protein. (109 aa)
	E9FU86_DAPPU	Uncharacterized protein. (321 aa)
	E9FVV3_DAPPU	Asp_Arg_Hydrox domain-containing protein. (397 aa)
	E9FZ53_DAPPU	Uncharacterized protein. (378 aa)

Your Current Organism:

Daphnia pulex

NCBI taxonomy Id: 6669
Other names: D. pulex, common water flea

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E9FRG0_DAPPU	E9GNE9_DAPPU	E9FRG0	E9GNE9	Protein kinase domain-containing protein.	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	0.400
E9FRG0_DAPPU	E9H5Q6_DAPPU	E9FRG0	E9H5Q6	Protein kinase domain-containing protein.	Uncharacterized protein.	0.730
E9FRG0_DAPPU	E9HD18_DAPPU	E9FRG0	E9HD18	Protein kinase domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.528
E9FRG0_DAPPU	E9HP27_DAPPU	E9FRG0	E9HP27	Protein kinase domain-containing protein.	RING-type domain-containing protein.	0.730
E9FSM2_DAPPU	E9HD18_DAPPU	E9FSM2	E9HD18	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.913
E9FZ53_DAPPU	E9GDU6_DAPPU	E9FZ53	E9GDU6	Uncharacterized protein.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.998
E9G4N7_DAPPU	E9GDU6_DAPPU	E9G4N7	E9GDU6	Uncharacterized protein; Belongs to the protein kinase superfamily.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.531
E9G767_DAPPU	E9GTR4_DAPPU	E9G767	E9GTR4	Uncharacterized protein.	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	0.702
E9G767_DAPPU	E9H0N0_DAPPU	E9G767	E9H0N0	Uncharacterized protein.	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	0.702
E9G767_DAPPU	E9HEP5_DAPPU	E9G767	E9HEP5	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.702
E9GDU6_DAPPU	E9FZ53_DAPPU	E9GDU6	E9FZ53	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein.	0.998
E9GDU6_DAPPU	E9G4N7_DAPPU	E9GDU6	E9G4N7	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.531
E9GDU6_DAPPU	E9GPY9_DAPPU	E9GDU6	E9GPY9	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Protein kinase domain-containing protein.	0.531
E9GDU6_DAPPU	E9HRZ7_DAPPU	E9GDU6	E9HRZ7	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Protein kinase domain-containing protein.	0.531
E9GDU6_DAPPU	E9HS16_DAPPU	E9GDU6	E9HS16	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Protein kinase domain-containing protein.	0.531
E9GDU6_DAPPU	E9HTW1_DAPPU	E9GDU6	E9HTW1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Protein kinase domain-containing protein.	0.531
E9GI23_DAPPU	E9GNE9_DAPPU	E9GI23	E9GNE9	Uncharacterized protein.	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	0.483
E9GI23_DAPPU	E9GTR4_DAPPU	E9GI23	E9GTR4	Uncharacterized protein.	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	0.483
E9GI23_DAPPU	E9H0N0_DAPPU	E9GI23	E9H0N0	Uncharacterized protein.	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	0.483
E9GI23_DAPPU	E9HAH1_DAPPU	E9GI23	E9HAH1	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.601