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| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | cysK | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (312 aa) |
| | cysE | Serine O-acetyltransferase. (221 aa) |
| | ABC0220 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa) |
| | ABC0345 | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | iolA | Methylmalonate-semialdehyde dehydrogenase; Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. (491 aa) |
| | ABC0445 | Fructose-bisphosphate aldolase. (291 aa) |
| | kdgK | 2-keto-3-deoxygluconate kinase. (315 aa) |
| | ABC0523 | 2-dehydro-3-deoxyphosphogluconate aldolase. (210 aa) |
| | ABC0768 | 3-carboxymuconate cyclase. (354 aa) |
| | ABC0858 | Fructose-bisphosphate aldolase. (289 aa) |
| | ABC0900 | Formate dehydrogenase alpha subunit. (985 aa) |
| | ABC0918 | Malic enzyme. (389 aa) |
| | ABC0948 | Transketolase; Belongs to the transketolase family. (666 aa) |
| | ABC1106 | Transketolase; Belongs to the transketolase family. (668 aa) |
| | ABC1181 | Threonine dehydratase. (322 aa) |
| | ABC1244 | Conserved hypothetical protein. (125 aa) |
| | ABC1283 | Catalase; Belongs to the catalase family. (488 aa) |
| | ABC1431 | Phosphoglycerate mutase. (201 aa) |
| | ABC1507 | Biotin carboxylase. (453 aa) |
| | ABC1508 | Biotin carboxyl carrier protein. (70 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (364 aa) |
| | glcK | Glucokinase. (326 aa) |
| | citG | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa) |
| | ABC1752 | Lactoylglutathione lyase. (137 aa) |
| | mmgD | Citrate synthase; Belongs to the citrate synthase family. (373 aa) |
| | iolA2 | Methylmalonate-semialdehyde dehydrogenase; Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. (486 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa) |
| | ABC1926 | Decarboxylating 6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (469 aa) |
| | gntK | Gluconokinase; Belongs to the FGGY kinase family. (516 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (414 aa) |
| | odhB | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa) |
| | odhA | 2-oxoglutarate dehydrogenase E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (943 aa) |
| | citB | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa) |
| | glcB | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (727 aa) |
| | sucD | succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (304 aa) |
| | sucC | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | sdaAA | L-serine dehydratase alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. (296 aa) |
| | sdaAB | L-serine dehydratase beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. (220 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (215 aa) |
| | pycA | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1149 aa) |
| | pdhD | Pyruvate dehydrogenase E3 component. (468 aa) |
| | pdhC | Pyruvate dehydrogenase E2 component. (425 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component beta subunit. (325 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (361 aa) |
| | lpd | Branched-chain alpha-keto acid dehydrogenase E3 component. (473 aa) |
| | accC | acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa) |
| | accB | acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa) |
| | gcvPB | Glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (491 aa) |
| | gcvPA | Glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (448 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (367 aa) |
| | ABC2572 | propionyl-CoA carboxylase beta chain. (499 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur protein. (250 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit. (589 aa) |
| | sdhC | Succinate dehydrogenase cytochrome b558 subunit. (202 aa) |
| | gapB | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (344 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (314 aa) |
| | citC | Isocitrate dehydrogenase [NADP]. (421 aa) |
| | citZ | Citrate synthase II; Belongs to the citrate synthase family. (371 aa) |
| | pykA | Pyruvate kinase; Belongs to the pyruvate kinase family. (584 aa) |
| | pfk | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (324 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (280 aa) |
| | ABC2723 | Malic enzyme. (410 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa) |
| | acsA | Acetyl-coenzyme A synthetase. (569 aa) |
| | acoC | Acetoin dehydrogenase E2 component. (410 aa) |
| | acoL | Acetoin dehydrogenase E3 component. (399 aa) |
| | ABC2792 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase [ATP]; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (527 aa) |
| | pgi | Glucose-6-phosphate isomerase A. (451 aa) |
| | ABC2973 | Isocitrate lyase. (423 aa) |
| | gcvH | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (146 aa) |
| | ABC2990 | 3-hydroxyacyl-CoA dehydrogenase. (787 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | pgm | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Essential for rapid growth and for sporulation. Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. (510 aa) |
| | tpi | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | pgk | 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | ABC3136 | 2-dehydro-3-deoxyphosphogluconate aldolase. (211 aa) |
| | prs-2 | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | ABC3195 | Fructose-bisphosphate aldolase. (289 aa) |
| | ABC3255 | Acetyl-coenzyme A synthetase. (522 aa) |
| | hxlA | Hexulose-6-phosphate synthase. (208 aa) |
| | ABC3352 | 2-keto-3-deoxygluconate kinase. (316 aa) |
| | rpiA | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (228 aa) |
| | hxlB | 6-phospho-3-hexuloisomerase. (183 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa) |
| | ABC3413 | Glutathione-dependent formaldehyde dehydrogenase. (379 aa) |
| | adhB | Glutathione-dependent formaldehyde dehydrogenase. (377 aa) |
| | ABC3502 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (334 aa) |
| | ABC3505 | Fructose-bisphosphate aldolase. (284 aa) |
| | ABC3608 | Fructose-1,6-bisphosphatase. (318 aa) |
| | ABC3611 | Ribose 5-phosphate isomerase B. (153 aa) |
| | ABC3617 | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (378 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | ABC3865 | Ribose 5-phosphate isomerase B. (149 aa) |
| | ABC3880 | Fructose-1,6-bisphosphatase. (321 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa) |
| | fbaA | Fructose-bisphosphate aldolase. (287 aa) |
| | mmgB | 3-hydroxybutyryl-CoA dehydrogenase. (283 aa) |
| | mmgA | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | pta | Phosphotransacetylase. (331 aa) |
| | katX | Catalase; Belongs to the catalase family. (540 aa) |
| | citA | Citrate synthase I; Belongs to the citrate synthase family. (363 aa) |
