(15 nodes) Two-component regulatory system, and PPM-type phosphatase-like domain superfamily network (Vibrio harveyi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AMF97104.1	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (368 aa)
	AMF97733.1	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
	cpxA	Two-component sensor protein; Part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
	ompR	Part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
	envZ	Osmolarity sensor protein; Membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
	phoB	Two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
	phoR	PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
	AMF99465.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
	AMF99466.1	ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
	AMG00078.1	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
	AMG00079.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
	AMG00423.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
	AMG00424.1	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
	AMG00453.1	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
	AMG00454.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)

Your Current Organism:

Vibrio harveyi

NCBI taxonomy Id: 669
Other names: ATCC 14126, Achromobacter harveyi, Beneckea harveyi, Beneckea neptuna, CAIM 513, CCUG 28584, CECT 525, CIP 103192, DSM 19623, IFO 15634, LMG 4044, LMG:4044, Lucibacterium harveyi, NBRC 15634, NCCB 80033, NCTC 12970, Photobacterium harveyi, Pseudomonas harveyi, V. harveyi, Vibrio carchariae, Vibrio sp. HENC-01, Vibrio sp. HENC-02, Vibrio sp. PG 001, Vibrio sp. PG 002, Vibrio sp. PG 006, Vibrio sp. PG 007, Vibrio trachuri

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMF97104.1	AMF99465.1	AL538_04795	AL538_17185	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.737
AMF97104.1	AMF99466.1	AL538_04795	AL538_17190	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.745
AMF97104.1	AMG00078.1	AL538_04795	AL538_20455	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.776
AMF97104.1	AMG00079.1	AL538_04795	AL538_20460	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.792
AMF97104.1	AMG00423.1	AL538_04795	AL538_22325	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.812
AMF97104.1	AMG00454.1	AL538_04795	AL538_22485	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.747
AMF97104.1	cpxA	AL538_04795	AL538_08375	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component sensor protein; Part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.781
AMF97104.1	envZ	AL538_04795	AL538_10360	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Osmolarity sensor protein; Membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.734
AMF97104.1	phoR	AL538_04795	AL538_12200	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.418
AMF97733.1	AMF99465.1	AL538_08370	AL538_17185	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.806
AMF97733.1	AMF99466.1	AL538_08370	AL538_17190	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.	ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.930
AMF97733.1	AMG00078.1	AL538_08370	AL538_20455	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.910
AMF97733.1	AMG00079.1	AL538_08370	AL538_20460	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.862
AMF97733.1	AMG00423.1	AL538_08370	AL538_22325	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.856
AMF97733.1	AMG00454.1	AL538_08370	AL538_22485	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
AMF97733.1	cpxA	AL538_08370	AL538_08375	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component sensor protein; Part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
AMF97733.1	envZ	AL538_08370	AL538_10360	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.	Osmolarity sensor protein; Membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.805
AMF97733.1	phoR	AL538_08370	AL538_12200	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.783
AMF99465.1	AMF97104.1	AL538_17185	AL538_04795	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.737
AMF99465.1	AMF97733.1	AL538_17185	AL538_08370	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.806

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