STRINGSTRING
uvrC uvrC KOH18042.1 KOH18042.1 KOH18041.1 KOH18041.1 KOH17340.1 KOH17340.1 GltB GltB KOH19706.1 KOH19706.1 KOH19590.1 KOH19590.1 dnaG dnaG KOH19703.1 KOH19703.1 dhaL dhaL KOH19536.1 KOH19536.1 KOH19527.1 KOH19527.1 KOH19521.1 KOH19521.1 leuD leuD KOH17346.1 KOH17346.1 KOH17363.1 KOH17363.1 cobQ cobQ KOH18053.1 KOH18053.1 moaD moaD KOH18186.1 KOH18186.1 KOH18246.1 KOH18246.1 accD-2 accD-2 CysN CysN KOH19479.1 KOH19479.1 KOH19469.1 KOH19469.1 hslV hslV hslU hslU KOH18353.1 KOH18353.1 uvrD uvrD KOH24634.1 KOH24634.1 ribA ribA KOH24795.1 KOH24795.1 rpoB rpoB rpoC rpoC dnaN dnaN rnpA rnpA KOH23801.1 KOH23801.1 KOH23802.1 KOH23802.1 KOH22546.1 KOH22546.1 hscB hscB KOH22248.1 KOH22248.1 KOH22249.1 KOH22249.1 KOH22255.1 KOH22255.1 KOH22274.1 KOH22274.1 KOH22372.1 KOH22372.1 accD accD KOH22402.1 KOH22402.1 gcvH gcvH glgC glgC dsrH dsrH KOH21985.1 KOH21985.1 accB accB accC accC KOH20843.1 KOH20843.1 ruvB ruvB ruvA ruvA ruvC ruvC glgC-2 glgC-2 clpX clpX KOH21381.1 KOH21381.1 KOH21383.1 KOH21383.1 KOH21384.1 KOH21384.1 sdhA sdhA SdhC SdhC holA holA KOH21517.1 KOH21517.1 ribH ribH KOH20671.1 KOH20671.1 KOH20636.1 KOH20636.1 KOH20651.1 KOH20651.1 rpoZ rpoZ KOH19386.1 KOH19386.1 recD recD glpD glpD ebgA ebgA KOH18476.1 KOH18476.1 KOH25217.1 KOH25217.1 thiH thiH aceF aceF aceE aceE eno eno cysC cysC trmB trmB KOH17229.1 KOH17229.1 KOH17316.1 KOH17316.1 KOH17530.1 KOH17530.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uvrCThe UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; Derived by automated computational analysis using gene prediction method: Protein Homology. (588 aa)
KOH18042.1Ribonucleotide-diphosphate reductase subunit beta; B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
KOH18041.1Ribonucleotide-diphosphate reductase subunit alpha; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (760 aa)
KOH17340.1methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
GltBGlutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1517 aa)
KOH19706.1Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
KOH19590.1Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (586 aa)
KOH19703.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (814 aa)
dhaLDihydroxyacetone kinase; With DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
KOH19536.1With DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
KOH19527.1Acetolactate synthase 3 catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
KOH19521.1Isopropylmalate isomerase; Dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
KOH17346.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
KOH17363.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
cobQCobalamin biosynthesis protein CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (483 aa)
KOH18053.1Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; Derived by automated computational analysis using gene prediction method: Protein Homology. (787 aa)
moaDMolybdopterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
KOH18186.1The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; Derived by automated computational analysis using gene prediction method: Protein Homology. (676 aa)
KOH18246.1DNA polymerase III subunit gamma/tau; Derived by automated computational analysis using gene prediction method: Protein Homology. (711 aa)
accD-2acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (308 aa)
CysNSulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
KOH19479.1Sulfate adenylyltransferase subunit 2; With CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
KOH19469.1DNA-directed RNA polymerase subunit alpha; Catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
hslVATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (183 aa)
hslUATP-dependent protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (443 aa)
KOH18353.1acetyl-CoA carboxylase subunit alpha; Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
uvrDDNA-dependent helicase II; Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair; Derived by automated computational analysis using gene prediction method: Protein Homology. (724 aa)
KOH24634.1Alpha-glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (896 aa)
ribACatalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
KOH24795.1Carboxylate--amine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (1342 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1400 aa)
dnaNDNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa)
rnpARibonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (118 aa)
KOH23801.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (94 aa)
KOH23802.1Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)
KOH22546.1Exodeoxyribonuclease VII large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
hscBCobalamin 5'-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HscB family. (171 aa)
KOH22248.1Catalyzes the hydration of gamma-carboxygeranoyl-CoA to 3-hydroxy-gamma-carboxygeranoyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
KOH22249.1methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
KOH22255.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
KOH22274.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
KOH22372.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa)
KOH22402.1Glycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. (954 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
glgCGlucose-1-phosphate adenylyltransferase; Catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
dsrHSulfur relay protein TusB; Derived by automated computational analysis using gene prediction method: Protein Homology. (91 aa)
KOH21985.1Glycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
accBacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (152 aa)
accCacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
KOH20843.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
ruvAATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (204 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (173 aa)
glgC-2Glucose-1-phosphate adenylyltransferase; Catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
clpXClp protease ClpX; Binds and unfolds substrates as part of the ClpXP protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
KOH21381.1succinyl-CoA synthetase subunit alpha; Catalyzes the only substrate-level phosphorylation in the TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
KOH21383.1Dihydrolipoamide succinyltransferase; Component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
KOH21384.12-oxoglutarate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (941 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (588 aa)
SdhCSuccinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
holADNA polymerase III subunit delta; Required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
KOH21517.1Exodeoxyribonuclease VII small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (80 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (156 aa)
KOH20671.1Excinuclease ABC subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology. (940 aa)
KOH20636.1RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living a [...] (488 aa)
KOH20651.1Involved in the allosteric regulation of aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (90 aa)
KOH19386.1Phosphopantothenoylcysteine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
recDExodeoxyribonuclease V subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (715 aa)
glpDGlycerol-3-phosphate dehydrogenase; In Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (519 aa)
ebgAbeta-D-galactosidase; In Escherichia coli this is the second beta-galactosidase system; Derived by automated computational analysis using gene prediction method: Protein Homology. (1032 aa)
KOH18476.1DNA polymerase III subunit psi; With the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
KOH25217.1Thiamine biosynthesis protein ThiS; With ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (78 aa)
thiHIn Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
aceFPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (627 aa)
aceEE1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; Derived by automated computational analysis using gene prediction method: Protein Homology. (887 aa)
enoEnolase; Catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (205 aa)
trmBtRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
KOH17229.1ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (675 aa)
KOH17316.1Guanosine 5'-monophosphate oxidoreductase; Catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
KOH17530.13-methylcrotonyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (691 aa)
Your Current Organism:
Vibrio parahaemolyticus
NCBI taxonomy Id: 670
Other names: ATCC 17802, Beneckea parahaemolytica, CAIM 320, CCUG 14474, CCUG 15657, CCUG 4224, CIP 75.2, DSM 10027, IFO 12711, LMG 2850, LMG:2850, NBRC 12711, NCCB 77010, NCCB 77018, NCTC 10903, NRRL B-4167, Oceanomonas parahaemolytica, Pasteurella parahaemolytica, V. parahaemolyticus
Server load: low (18%) [HD]