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| | SFR33546.1 | Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist. (316 aa) |
| | SFR33506.1 | Aromatic amino acid aminotransferase apoenzyme. (394 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa) |
| | SFR33435.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (555 aa) |
| | SFR33241.1 | Pyruvate kinase; Belongs to the pyruvate kinase family. (483 aa) |
| | argH | Argininosuccinate lyase. (466 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (519 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa) |
| | SFR32044.1 | Cystathione beta-lyase. (389 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (289 aa) |
| | hisD-3 | Sulfopropanediol 3-dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | SFR59050.1 | Chorismate mutase. (97 aa) |
| | SFR58766.1 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa) |
| | SFR58495.1 | Prephenate dehydrogenase. (304 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (338 aa) |
| | SFR58311.1 | L-threonine aldolase. (350 aa) |
| | SFR58238.1 | Asparagine synthase. (489 aa) |
| | SFR58120.1 | L-threonine synthase. (462 aa) |
| | SFR58103.1 | Ribosomal-protein-alanine N-acetyltransferase. (194 aa) |
| | SFR58010.1 | Aspartate kinase; Belongs to the aspartokinase family. (412 aa) |
| | SFR57968.1 | Threonine dehydratase. (346 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | SFR57515.1 | 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. (477 aa) |
| | SFR57053.1 | Methyltransferase, FkbM family. (219 aa) |
| | argD | acetylornithine/N-succinyldiaminopimelate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (392 aa) |
| | SFR56557.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (301 aa) |
| | SFR56426.1 | Histidinol-phosphate aminotransferase. (367 aa) |
| | SFR56194.1 | Haloacid dehalogenase-like hydrolase. (290 aa) |
| | SFR55971.1 | Saccharopine dehydrogenase NADP binding domain-containing protein. (549 aa) |
| | SFR55524.1 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa) |
| | SFR54820.1 | Acetylornithine deacetylase. (383 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa) |
| | SFR53961.1 | DNA transformation protein. (107 aa) |
| | SFR53194.1 | L-glutamine synthetase. (460 aa) |
| | SFR53175.1 | Glutamate--putrescine ligase; Belongs to the glutamine synthetase family. (444 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (262 aa) |
| | SFR52737.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (527 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa) |
| | SFR51768.1 | L-glutamine synthetase. (468 aa) |
| | SFR51542.1 | Serine O-acetyltransferase. (269 aa) |
| | SFR51496.1 | Fructose-bisphosphate aldolase. (297 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (392 aa) |
| | SFR51469.1 | Glyceraldehyde-3-phosphate dehydrogenase (NAD+); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | SFR51437.1 | Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa) |
| | SFR51382.1 | Transketolase; Belongs to the transketolase family. (671 aa) |
| | SFR50988.1 | Cysteine synthase A. (342 aa) |
| | SFR50521.1 | Arginine:pyruvate transaminase. (390 aa) |
| | SFR50502.1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (539 aa) |
| | SFR50331.1 | 5-methyltetrahydrofolate--homocysteine methyltransferase. (360 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (422 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa) |
| | SFR49269.1 | Acetolactate synthase, large subunit. (586 aa) |
| | SFR49254.1 | Acetolactate synthase, small subunit. (187 aa) |
| | SFR49164.1 | Aspartate/methionine/tyrosine aminotransferase. (390 aa) |
| | SFR49135.1 | Anthranilate synthase, component II. (198 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (271 aa) |
| | SFR49076.1 | Citrate synthase; Belongs to the citrate synthase family. (429 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa) |
| | SFR48732.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (456 aa) |
| | SFR48594.1 | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (402 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (120 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (306 aa) |
| | SFR48211.1 | Probable phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (192 aa) |
| | SFR48083.1 | Aspartate/methionine/tyrosine aminotransferase. (378 aa) |
| | SFR48001.1 | 5-methyltetrahydrofolate--homocysteine methyltransferase. (337 aa) |
| | SFR47989.1 | 5-methyltetrahydrofolate--homocysteine methyltransferase. (234 aa) |
| | rsmA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (280 aa) |
| | SFR47079.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (537 aa) |
| | SFR46754.1 | Threonine dehydratase. (323 aa) |
| | SFR46684.1 | Fructose-bisphosphate aldolase. (278 aa) |
| | SFR46435.1 | Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (328 aa) |
| | SFR46214.1 | 3-isopropylmalate dehydrogenase. (362 aa) |
| | SFR46117.1 | Glutamine synthetase. (455 aa) |
| | SFR45838.1 | Shikimate dehydrogenase. (283 aa) |
| | SFR44824.1 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (922 aa) |
| | SFR44748.1 | Aspartate aminotransferase. (400 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisH | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (240 aa) |
| | hisF | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (102 aa) |
| | SFR43142.1 | Myo-inositol-1(or 4)-monophosphatase. (265 aa) |
| | SFR42824.1 | Septum formation protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (195 aa) |
| | hisD-2 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa) |
| | SFR42685.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (533 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (185 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (372 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | SFR41883.1 | Homoserine dehydrogenase. (427 aa) |
| | SFR41696.1 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (232 aa) |
| | SFR41688.1 | ATP phosphoribosyltransferase regulatory subunit. (343 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | SFR41032.1 | Branched-chain amino acid aminotransferase. (286 aa) |
| | SFR40562.1 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (317 aa) |
| | trpF-2 | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (223 aa) |
| | SFR40193.1 | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | SFR40154.1 | Indole-3-glycerol phosphate synthase. (236 aa) |
| | SFR40147.1 | Anthranilate phosphoribosyltransferase. (347 aa) |
| | SFR39948.1 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (735 aa) |
| | SFR39525.1 | Anthranilate phosphoribosyltransferase. (313 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (211 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (448 aa) |
| | SFR38724.1 | Ribose 5-phosphate isomerase B. (149 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (393 aa) |
| | SFR38295.1 | Threonine dehydratase. (326 aa) |
| | SFR37901.1 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (467 aa) |
| | SFR37846.1 | Sulfoacetaldehyde acetyltransferase; Belongs to the TPP enzyme family. (589 aa) |
| | hisD | Sulfopropanediol 3-dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | SFR37266.1 | Succinyl-diaminopimelate desuccinylase. (432 aa) |
| | SFR37200.1 | Serine O-acetyltransferase. (250 aa) |
| | SFR36949.1 | Prephenate dehydratase. (277 aa) |
| | SFR36812.1 | Saccharopine dehydrogenase (NAD+, L-lysine-forming). (348 aa) |
| | SFR36682.1 | Protein of unknown function. (57 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (266 aa) |
| | SFR36408.1 | Aspartate/methionine/tyrosine aminotransferase. (390 aa) |
| | SFR36356.1 | Transmembrane secretion effector. (417 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa) |
| | SFR35905.1 | Phosphoserine phosphatase. (290 aa) |
| | SFR35897.1 | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (381 aa) |
| | SFR35893.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa) |
| | SFR35601.1 | Acetyltransferase (GNAT) family protein. (235 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (411 aa) |
| | SFR35362.1 | UPF0716 protein FxsA. (162 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (277 aa) |
| | SFR35330.1 | Septum formation protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (199 aa) |
| | SFR35081.1 | Glutamate synthase (NADPH) large subunit. (1512 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (506 aa) |
| | leuC | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa) |
| | leuD | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (368 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (289 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (415 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa) |
| | SFR34641.1 | Branched-chain amino acid aminotransferase. (302 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (275 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (382 aa) |
| | SFR34486.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (325 aa) |
| | SFR33881.1 | Arginase; Belongs to the arginase family. (309 aa) |
| | SFR33741.1 | Asparagine synthetase B (glutamine-hydrolyzing). (617 aa) |
| | SFR33520.1 | Hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (208 aa) |
