| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGK57486.1 | AGK57487.1 | HYPDE_29038 | HYPDE_29043 | COG3494 Uncharacterized protein conserved in bacteria. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.950 |
| AGK57486.1 | AGK57718.1 | HYPDE_29038 | HYPDE_30218 | COG3494 Uncharacterized protein conserved in bacteria. | COG1560 Lauroyl/myristoyl acyltransferase. | 0.704 |
| AGK57486.1 | AGK58977.1 | HYPDE_29038 | HYPDE_36528 | COG3494 Uncharacterized protein conserved in bacteria. | 3-deoxy-D-manno-octulosonic-acid transferase; COG2121 Uncharacterized protein conserved in bacteria. | 0.790 |
| AGK57486.1 | AGK59054.1 | HYPDE_29038 | HYPDE_36913 | COG3494 Uncharacterized protein conserved in bacteria. | KpsF/GutQ family protein; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.718 |
| AGK57486.1 | fabZ | HYPDE_29038 | HYPDE_29028 | COG3494 Uncharacterized protein conserved in bacteria. | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.831 |
| AGK57486.1 | kdsA | HYPDE_29038 | HYPDE_31368 | COG3494 Uncharacterized protein conserved in bacteria. | 2-dehydro-3-deoxyphosphooctonate aldolase; COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; Belongs to the KdsA family. | 0.586 |
| AGK57486.1 | kdsB | HYPDE_29038 | HYPDE_37408 | COG3494 Uncharacterized protein conserved in bacteria. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.617 |
| AGK57486.1 | lpxA | HYPDE_29038 | HYPDE_29033 | COG3494 Uncharacterized protein conserved in bacteria. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.944 |
| AGK57486.1 | lpxC | HYPDE_29038 | HYPDE_23783 | COG3494 Uncharacterized protein conserved in bacteria. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.713 |
| AGK57486.1 | lpxD | HYPDE_29038 | HYPDE_29023 | COG3494 Uncharacterized protein conserved in bacteria. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.896 |
| AGK57486.1 | lpxK | HYPDE_29038 | HYPDE_36533 | COG3494 Uncharacterized protein conserved in bacteria. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.787 |
| AGK57487.1 | AGK57486.1 | HYPDE_29043 | HYPDE_29038 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | COG3494 Uncharacterized protein conserved in bacteria. | 0.950 |
| AGK57487.1 | AGK57718.1 | HYPDE_29043 | HYPDE_30218 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | COG1560 Lauroyl/myristoyl acyltransferase. | 0.782 |
| AGK57487.1 | AGK58977.1 | HYPDE_29043 | HYPDE_36528 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 3-deoxy-D-manno-octulosonic-acid transferase; COG2121 Uncharacterized protein conserved in bacteria. | 0.847 |
| AGK57487.1 | AGK59054.1 | HYPDE_29043 | HYPDE_36913 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | KpsF/GutQ family protein; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.879 |
| AGK57487.1 | fabZ | HYPDE_29043 | HYPDE_29028 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.904 |
| AGK57487.1 | kdsA | HYPDE_29043 | HYPDE_31368 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 2-dehydro-3-deoxyphosphooctonate aldolase; COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; Belongs to the KdsA family. | 0.842 |
| AGK57487.1 | kdsB | HYPDE_29043 | HYPDE_37408 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.845 |
| AGK57487.1 | lpxA | HYPDE_29043 | HYPDE_29033 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.993 |
| AGK57487.1 | lpxC | HYPDE_29043 | HYPDE_23783 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.858 |