STRINGSTRING
lpxC lpxC lpxD lpxD fabZ fabZ lpxA lpxA AGK57486.1 AGK57486.1 AGK57487.1 AGK57487.1 AGK57718.1 AGK57718.1 kdsA kdsA AGK58977.1 AGK58977.1 lpxK lpxK AGK59054.1 AGK59054.1 kdsB kdsB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (314 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (353 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (167 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (268 aa)
AGK57486.1COG3494 Uncharacterized protein conserved in bacteria. (431 aa)
AGK57487.1lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (413 aa)
AGK57718.1COG1560 Lauroyl/myristoyl acyltransferase. (281 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; Belongs to the KdsA family. (288 aa)
AGK58977.13-deoxy-D-manno-octulosonic-acid transferase; COG2121 Uncharacterized protein conserved in bacteria. (689 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (342 aa)
AGK59054.1KpsF/GutQ family protein; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. (343 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa)
Your Current Organism:
Hyphomicrobium denitrificans 1NES1
NCBI taxonomy Id: 670307
Other names: H. denitrificans 1NES1, Hyphomicrobium denitrificans str. 1NES1, Hyphomicrobium denitrificans strain 1NES1
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