(60 nodes) Mixed, incl. Regulation of APC/C activators between G1/S and early anaphase, and Polo-like kinase mediated events network (Heterostelium album)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fttB	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (253 aa)
	PPL_00358	Neurofibromin-like protein. (1959 aa)
	PPL_00392	Protein kinase domain-containing protein. (339 aa)
	wdr5	WD40 repeat-containing protein. (392 aa)
	cycB	Cyclin; Belongs to the cyclin family. (415 aa)
	anapc6	TPR repeat-containing protein. (544 aa)
	ube2c	Ubiquitin-conjugating enzyme E2; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	bub1	Uncharacterized protein. (1152 aa)
	PPL_01732	Uncharacterized protein. (422 aa)
	PPL_02493	C2 NT-type domain-containing protein. (734 aa)
	bub3	WD40 repeat-containing protein. (324 aa)
	cdc20	WD40 repeat-containing protein. (458 aa)
	PPL_03374	RmlC-like cupin family protein. (1267 aa)
	PPL_03486	Uncharacterized protein. (510 aa)
	PPL_03897	DNA-binding HORMA domain-containing protein. (201 aa)
	PPL_03943	Protein kinase domain-containing protein. (351 aa)
	PPL_04007	Protein kinase domain-containing protein. (1164 aa)
	PPL_04068	Ubiquitin-like domain-containing protein. (106 aa)
	mad1	Mitotic spindle assembly checkpoint protein 1. (673 aa)
	cdc25	Tyrosine phosphatase. (758 aa)
	fpaA	Cytosolic glycoprotein FP21; Belongs to the SKP1 family. (172 aa)
	alaS	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (958 aa)
	anapc8	Anaphase promoting complex subunit 8. (638 aa)
	malaS	Alanyl-tRNA synthetase. (804 aa)
	fhkD	Uncharacterized protein. (684 aa)
	PPL_04982	Peptidase C50 domain-containing protein. (2045 aa)
	cdk1	P34-cdc2 protein; Belongs to the protein kinase superfamily. (297 aa)
	PPL_05030	Neurofibromin. (2564 aa)
	ube2s	Ubiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (234 aa)
	anapc11	Anaphase promoting complex subunit 11. (135 aa)
	anapc5	Anaphase promoting complex subunit 5. (740 aa)
	PPL_05758	WD_REPEATS_REGION domain-containing protein. (1462 aa)
	PPL_05969	Putative purinergic receptor. (355 aa)
	cycA	Cyclin; Belongs to the cyclin family. (599 aa)
	PPL_06366	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (301 aa)
	p2xE	Putative purinergic receptor. (364 aa)
	anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (768 aa)
	PPL_07680	Uncharacterized protein. (308 aa)
	cks1	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (83 aa)
	anapc1	Anaphase promoting complex subunit 1. (1500 aa)
	anapc7	Anaphase promoting complex subunit 7. (599 aa)
	PPL_08672	ANK_REP_REGION domain-containing protein. (555 aa)
	anapc3	Anaphase promoting complex subunit 3. (1113 aa)
	PPL_09122	Uncharacterized protein. (1034 aa)
	PPL_09272	Uncharacterized protein. (902 aa)
	plk	Serine/threonine-protein kinase PLK. (776 aa)
	PPL_09854	Uncharacterized protein. (249 aa)
	PPL_09435	WD_REPEATS_REGION domain-containing protein. (486 aa)
	PPL_09981	Ras GTPase activation domain-containing protein. (967 aa)
	anapc4	Anaphase promoting complex subunit 4. (605 aa)
	PPL_10415	Uncharacterized protein. (650 aa)
	PPL_10465	Putative acyl-CoA N-acyltransferase. (306 aa)
	PPL_10917	ANK_REP_REGION domain-containing protein. (555 aa)
	mtaA	XMAP215 family protein. (1907 aa)
	anapc10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (225 aa)
	PPL_11755	Protein kinase domain-containing protein. (680 aa)
	PPL_11791	WD40 repeat-containing protein. (2401 aa)
	nek2	Protein serine/threonine kinase. (396 aa)
	PPL_11535	Protein kinase domain-containing protein. (894 aa)
	PPL_11545	Uncharacterized protein. (327 aa)

Your Current Organism:

Heterostelium album

NCBI taxonomy Id: 670386
Other names: H. album PN500, Heterostelium album PN500, Heterostelium pallidum PN500, Polysphondylium pallidum PN500

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PPL_00358	PPL_03374	D3AW84	D3B4P9	Neurofibromin-like protein.	RmlC-like cupin family protein.	0.648
PPL_00358	PPL_03486	D3AW84	D3B510	Neurofibromin-like protein.	Uncharacterized protein.	0.651
PPL_00358	PPL_03897	D3AW84	D3B5F9	Neurofibromin-like protein.	DNA-binding HORMA domain-containing protein.	0.772
PPL_00358	PPL_05758	D3AW84	D3BB26	Neurofibromin-like protein.	WD_REPEATS_REGION domain-containing protein.	0.520
PPL_00358	PPL_07680	D3AW84	D3BGM8	Neurofibromin-like protein.	Uncharacterized protein.	0.516
PPL_00358	PPL_08672	D3AW84	D3BJE7	Neurofibromin-like protein.	ANK_REP_REGION domain-containing protein.	0.516
PPL_00358	PPL_09435	D3AW84	D3BPG7	Neurofibromin-like protein.	WD_REPEATS_REGION domain-containing protein.	0.739
PPL_00358	PPL_10415	D3AW84	D3BR12	Neurofibromin-like protein.	Uncharacterized protein.	0.511
PPL_00358	PPL_10917	D3AW84	D3BSF0	Neurofibromin-like protein.	ANK_REP_REGION domain-containing protein.	0.516
PPL_00358	PPL_11545	D3AW84	D3BVF4	Neurofibromin-like protein.	Uncharacterized protein.	0.516
PPL_00358	PPL_11791	D3AW84	D3BUH1	Neurofibromin-like protein.	WD40 repeat-containing protein.	0.520
PPL_00358	alaS	D3AW84	D3B7Q7	Neurofibromin-like protein.	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.	0.564
PPL_00358	anapc1	D3AW84	D3BHM5	Neurofibromin-like protein.	Anaphase promoting complex subunit 1.	0.705
PPL_00358	anapc10	D3AW84	D3BU92	Neurofibromin-like protein.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.576
PPL_00358	anapc2	D3AW84	D3BDT3	Neurofibromin-like protein.	Anaphase promoting complex subunit 2; Belongs to the cullin family.	0.673
PPL_00358	anapc3	D3AW84	D3BKF9	Neurofibromin-like protein.	Anaphase promoting complex subunit 3.	0.651
PPL_00358	anapc4	D3AW84	D3BQT4	Neurofibromin-like protein.	Anaphase promoting complex subunit 4.	0.721
PPL_00358	anapc5	D3AW84	D3BA78	Neurofibromin-like protein.	Anaphase promoting complex subunit 5.	0.629
PPL_00358	anapc6	D3AW84	D3AYL4	Neurofibromin-like protein.	TPR repeat-containing protein.	0.673
PPL_00358	anapc7	D3AW84	D3BIH5	Neurofibromin-like protein.	Anaphase promoting complex subunit 7.	0.635