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| | DAMO_1255 | Protein of unknown function; No homology to any previously reported sequences. (118 aa) |
| | DAMO_1254 | Protein of unknown function; No homology to any previously reported sequences. (101 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine C-acetyltransferase); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (410 aa) |
| | pimB | Acetyl-CoA acetyltransferase with thiolase domain (Acetoacetyl-CoA thiolase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa) |
| | DAMO_1218 | Biotin/lipoic acid binding domain protein. (168 aa) |
| | accC | Acetyl CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (500 aa) |
| | DAMO_1216 | Putative propionyl-CoA carboxylase beta chain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (522 aa) |
| | acsA-2 | Acetyl-coenzyme A synthetase (Acetate--CoA ligase) (Acyl-activating enzyme). (650 aa) |
| | tyrC | Protein tyrC: Cyclohexadienyl dehydrogenase (Arogenate dehydrogenase) (ADH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (315 aa) |
| | aroF | 3-deoxy-7-phosphoheptulonate synthase; Phospho-2-dehydro-3-deoxyheptonate aldolase (Phospho-2-keto-3-deoxyheptonate aldolase) (DAHP synthetase) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase). (337 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (378 aa) |
| | pheA | P-protein [Includes: Chorismate mutase (CM); Prephenate dehydratase (PDT)]. (358 aa) |
| | lysC | Aspartokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartokinase family. (412 aa) |
| | metG | Methionyl-tRNA synthetase (Methionine--tRNA ligase) (MetRS); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (646 aa) |
| | glyA | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa) |
| | glnA-2 | Glutamine synthetase, type I, N-terminal (Glutamate--ammonia ligase I) (GSI); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glutamine synthetase family. (379 aa) |
| | glnA | Glutamine synthetase, type I, C-terminal (Glutamate--ammonia ligase I) (GSI) (fragment); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (87 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (330 aa) |
| | thrC-2 | Putative threonine synthase (TS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (417 aa) |
| | DAMO_1031 | Putative Sulfite/ferredoxin reductase (cysI); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (609 aa) |
| | cysK-2 | Pyridoxal-phosphate (PLP) dependent enzymes family; Function of strongly homologous gene; enzyme. (311 aa) |
| | cysK | Pyridoxal-phosphate (PLP) dependent enzymes family; Function of strongly homologous gene; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa) |
| | DAMO_1016 | Rhodanese-related sulfurtransferase-like protein precursor. (295 aa) |
| | DAMO_0982 | Putative pqq coenzyme synthesis protein (pqqE); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (371 aa) |
| | DAMO_0920 | Protein of unknown function; No homology to any previously reported sequences. (445 aa) |
| | DAMO_0883 | Beta-lactamase-like. (225 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI); Belongs to the LeuD family. (200 aa) |
| | gltB | Glutamate synthase [NADPH] large chain (NADPH-GOGAT); Function of strongly homologous gene; enzyme. (1529 aa) |
| | gltD | Glutamate synthase [NADPH] small chain, (NADPH-GOGAT); Function of strongly homologous gene; enzyme. (481 aa) |
| | pdhA | Similar to pyruvate dehydrogenase (Lipoamide) E1 component alpha chain. (323 aa) |
| | bfmBAB | 2-oxoisovalerate dehydrogenase subunit beta (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta). (323 aa) |
| | sucB | Similar to 2-oxoglutarate dehydrogenase complex E2 component. (403 aa) |
| | gcvPB | Probable glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (525 aa) |
| | gcvPA | Probable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (449 aa) |
| | gcvH | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | gcvT | Glycine cleavage system T-protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. (370 aa) |
| | cysE | Serine acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (234 aa) |
| | pfp | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (416 aa) |
| | DAMO_0683 | Homologs of previously reported genes of unknown function; Belongs to the thiolase-like superfamily. Thiolase family. (382 aa) |
| | argJ | Arginine biosynthesis bifunctional protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (405 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (356 aa) |
| | valS | Valyl-tRNA synthetase (Valine--tRNA ligase); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (938 aa) |
| | mutB | Fragment of Methylmalonyl-CoA mutase large subunit (MCM-alpha) (part 2); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (436 aa) |
| | DAMO_0613 | Radical SAM domain protein. (329 aa) |
| | DAMO_0612 | Radical SAM domain protein. (334 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (354 aa) |
| | hom | Homoserine dehydrogenase (HDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (434 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (FGAM synthase I); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (240 aa) |
| | cysS | Cysteine--tRNA ligase; Function of strongly homologous gene; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (530 aa) |
| | DAMO_0506 | Protein of unknown function; No homology to any previously reported sequences. (90 aa) |
| | DAMO_0505 | Protein of unknown function; No homology to any previously reported sequences. (200 aa) |
| | leuB | 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa) |
| | DAMO_0488 | Glucose-6-phosphate isomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GPI family. (580 aa) |
| | DAMO_0487 | Putative 6-phosphogluconate dehydrogenase (gnd-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (327 aa) |
| | glk | Glucokinase (Glucose kinase); Belongs to the bacterial glucokinase family. (340 aa) |
| | bioD | Dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (245 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (447 aa) |
| | bioB | Biotin synthetase (Fragment); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (356 aa) |
| | DAMO_0472 | Homologs of previously reported genes of unknown function. (451 aa) |
| | DAMO_0467 | Putative 2, 3-diketo-5-methylthio-1-phosphopentane phosphatase (phosphoserine phosphatase) (serB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (247 aa) |
| | DAMO_0466 | Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa) |
| | DAMO_0425 | Homologs of previously reported genes of unknown function. (205 aa) |
| | tpiA | Triosephosphate isomerase (TIM) (Triose-phosphate isomerase); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | cbbK-2 | Phosphoglycerate kinase, partial 3' end; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (282 aa) |
| | cbbK | Phosphoglycerate kinase, partial 5' end; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (127 aa) |
| | proA | Gamma-glutamylphosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (420 aa) |
| | proB | Gamma-glutamate kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (383 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase (3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. (279 aa) |
| | pyrG | CTP synthase (UTP--ammonia ligase) (CTP synthetase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa) |
| | acsA | Acetyl-coenzyme A synthetase (Acetate--CoA ligase) (Acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa) |
| | DAMO_0156 | Putative acetolactate synthase large subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the TPP enzyme family. (541 aa) |
| | argM | Succinylornithine transaminase, also has acetylornitine transaminase activity, PLP-dependent; Function of strongly homologous gene; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa) |
| | DAMO_0149 | Homologs of previously reported genes of unknown function. (269 aa) |
| | DAMO_0147 | Protein of unknown function; No homology to any previously reported sequences. (253 aa) |
| | DAMO_0146 | Protein of unknown function; No homology to any previously reported sequences. (227 aa) |
| | DAMO_0145 | Putative dioxygenase VC_1345; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (413 aa) |
| | DAMO_0097 | Putative Diaminopimelate decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (435 aa) |
| | rkpK | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (440 aa) |
| | argH | Argininosuccinate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (465 aa) |
| | argG | Argininosuccinate synthase (Citrulline--aspartate ligase); Belongs to the argininosuccinate synthase family. Type 1 subfamily. (410 aa) |
| | argF | Ornithine carbamoyltransferase (OTCase); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (311 aa) |
| | argD | Acetylornithine transaminase (NAcOATase and DapATase), PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa) |
| | argB | Acetylglutamate kinase (NAG kinase) (AGK) (N-acetyl-L-glutamate 5-phosphotransferase); Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (303 aa) |
| | speA | Arginine decarboxylase. (487 aa) |
| | DAMO_0047 | Putative radical SAM domain-containing protein (fragment), 5' end; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (232 aa) |
| | DAMO_0046 | Putative radical SAM domain-containing protein (fragment), 3' end; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (157 aa) |
| | DAMO_0044 | Putative nucleoside phosphorylase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (271 aa) |
| | hycD | Similar to membrane-bound [NiFe]-hydrogenase-3, subunit D. (314 aa) |
| | DAMO_2790 | Glutamine amidotransferase, class I. (235 aa) |
| | ilvE | Putative branched-chain-amino-acid aminotransferase (BCAT); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (303 aa) |
| | DAMO_2744 | Protein of unknown function; No homology to any previously reported sequences. (204 aa) |
| | DAMO_2656 | Putative histidine biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the HisA/HisF family. (247 aa) |
| | glyS | Glycine tRNA synthetase, beta subunit; Function of strongly homologous gene; enzyme. (689 aa) |
| | glyQ | Glycine tRNA synthetase, alpha subunit; Function of strongly homologous gene; enzyme. (300 aa) |
| | DAMO_2610 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa) |
| | DAMO_2601 | Alcohol dehydrogenase, zinc-binding domain protein. (343 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (320 aa) |
| | DAMO_2587 | Glutamate synthase (NADPH). (500 aa) |
| | DAMO_2567 | Putative enoyl-CoA hydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (267 aa) |
| | hbdA | 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (295 aa) |
| | DAMO_2516 | Homologs of previously reported genes of unknown function. (136 aa) |
| | DAMO_2504 | Homologs of previously reported genes of unknown function. (160 aa) |
| | DAMO_2499 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); Function of strongly homologous gene; enzyme. (589 aa) |
| | DAMO_2471 | Putative aspartate ammonia-lyase (L-aspartase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (470 aa) |
| | proS | Prolyl-tRNA synthetase (Proline--tRNA ligase) (ProRS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttra [...] (572 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (358 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (384 aa) |
| | coaBC | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (401 aa) |
| | mtnA | 5-methylthioribose-1-phosphate isomerase (MTNA); Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (352 aa) |
| | DAMO_2413 | Putative heme D1 biosynthesis protein (nirJ) involved in nitrite reductase biosynthesis; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (406 aa) |
| | sufS | Highly similar to cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (417 aa) |
| | hisC-3 | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa) |
| | DAMO_2356 | Protein of unknown function; No homology to any previously reported sequences. (854 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (418 aa) |
| | dapF | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | dapB | Dihydrodipicolinate reductase (DHPR); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (268 aa) |
| | DAMO_2314 | Homologs of previously reported genes of unknown function. (253 aa) |
| | folK | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (176 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase) (KPHMT); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (280 aa) |
| | panC | Pantothenate synthetase (Pantoate--beta-alanine ligase); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | hisG | ATP phosphoribosyltransferase (ATP-PRTase) (ATP-PRT); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (227 aa) |
| | hisD | Histidinol dehydrogenase (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (429 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase 2 (Imidazole acetol-phosphate transaminase 2); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa) |
| | hisB | Fragment of imidazole glycerol phosphate synthase subunit hisH (part 1); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (195 aa) |
| | hisA | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (240 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (279 aa) |
| | hisI | Histidine biosynthesis bifunctional protein hisIE [Includes: Phosphoribosyl-AMP cyclohydrolase (PRA-CH); Phosphoribosyl-ATP pyrophosphatase (PRA-PH)]; In the N-terminal section; belongs to the PRA-CH family. (231 aa) |
| | gdh | Glutamate dehydrogenase (NAD(P)+) oxidoreductase protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (421 aa) |
| | eno | Enolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (392 aa) |
| | ppcA | Phosphoenolpyruvate carboxylase (PEPCase) (PEPC). (498 aa) |
| | DAMO_2145 | Branched chain amino acid: 2-keto-4-methylthiobutyrate aminotransferase / branched chain amino acid aminotransferase. (298 aa) |
| | carB | Carbamoyl phosphate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family. (1099 aa) |
| | carA | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (399 aa) |
| | pyrB | Aspartate carbamoyltransferase (catalytic subunit); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (309 aa) |
| | qor | Quinone oxidoreductase (NADPH:quinone reductase); Function of strongly homologous gene; enzyme. (322 aa) |
| | DAMO_2062 | Putative threonine synthase (TS) (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (618 aa) |
| | DAMO_2031 | AMP-dependent synthetase and ligase. (543 aa) |
| | icd | Isocitrate dehydrogenase [NADP] (IDH) (Oxalosuccinate decarboxylase) (NADP(+)-specific ICDH) (IDP). (472 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (309 aa) |
| | glmS | L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (611 aa) |
| | DAMO_1980 | Homologs of previously reported genes of unknown function. (510 aa) |
| | metH | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa) |
| | DAMO_1944 | Membrane protein of unknown function; No homology to any previously reported sequences. (414 aa) |
| | thrS | Threonyl-tRNA synthetase (Threonine--tRNA ligase) (ThrRS); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (680 aa) |
| | pheS | Phenylalanyl-tRNA synthetase alpha chain (Phenylalanine--tRNA ligase alpha chain); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (350 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta chain (Phenylalanine--tRNA ligase beta chain); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (805 aa) |
| | folD | Bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | DAMO_2830 | Homologs of previously reported genes of unknown function. (219 aa) |
| | DAMO_1848 | Homologs of previously reported genes of unknown function. (375 aa) |
| | tyrS | Tyrosyl-tRNA synthetase (Tyrosine--tRNA ligase) (TyrRS); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (415 aa) |
| | DAMO_1712 | Protein of unknown function; No homology to any previously reported sequences. (128 aa) |
| | ppdK | Pyruvate phosphate dikinase; Function of strongly homologous gene; enzyme; Belongs to the PEP-utilizing enzyme family. (885 aa) |
| | lysS | Lysyl-tRNA synthetase (Lysine--tRNA ligase) (LysRS); Belongs to the class-II aminoacyl-tRNA synthetase family. (500 aa) |
| | fabZ | (3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (159 aa) |
| | selD | Selenide, water dikinase (Selenophosphate synthetase) (Selenium donor protein); Synthesizes selenophosphate from selenide and ATP. (307 aa) |
| | apgM | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (400 aa) |
| | DAMO_1609 | Protein of unknown function; No homology to any previously reported sequences. (400 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (312 aa) |
| | pdhA-2 | Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (323 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa) |
| | pdhC | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (415 aa) |
| | folP | Dihydropteroate synthase (DHPS) (Dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (283 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (127 aa) |
| | gltX | Glutamyl-tRNA synthetase (Glutamate--tRNA ligase) (GluRS); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (466 aa) |
| | DAMO_1515 | N-acetylglutamate synthase; Belongs to the acetyltransferase family. (156 aa) |
| | argS | arginyl-tRNA synthetase; Function of strongly homologous gene; enzyme. (557 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (472 aa) |
| | yvdE | Putative glutamine amidotransferase-like protein yvdE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (239 aa) |
| | anmK | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (397 aa) |
| | Pm20d | Peptidase M20 domain-containing protein 2 (Aminoacylase 1-like protein 2); Belongs to the peptidase M20A family. (389 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein, methyltransferase domain; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (323 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase III (Beta-ketoacyl-ACP synthase III)(KAS III); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-l [...] (327 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase (MCT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (296 aa) |
| | acpP | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (81 aa) |
| | fabF | 3-oxoacyl-[acyl-carrier-protein] synthase II (Beta-ketoacyl-ACP synthase II) (KAS II); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (406 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (365 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase (IGPS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. (267 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase (PRAI); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpF family. (207 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa) |
| | DAMO_1405 | Exported protein of unknown function; No homology to any previously reported sequences. (270 aa) |
| | aroC | Fragment of bifunctional: shikimate kinase (N-terminal); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (387 aa) |
| | aroQ | 3-dehydroquinate dehydratase type 2; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (156 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (434 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (290 aa) |
| | ilvC | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa) |
| | ilvH | Acetolactate synthase small subunit (Acetohydroxy-acid synthase small subunit) (AHAS) (ALS). (205 aa) |
| | ilvI | Acetolactate synthase large subunit (AHAS) (Acetohydroxy-acid synthase large subunit) (ALS); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (580 aa) |
| | leuS | Leucine tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (864 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | leuA | 2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (886 aa) |
| | DAMO_3172 | FAD linked oxidase-like protein. (453 aa) |
| | glcD | Glycolate oxidase, subunit GlcD; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (485 aa) |
| | ald | Alanine dehydrogenase (Stage V sporulation protein N); Belongs to the AlaDH/PNT family. (372 aa) |
| | ileS | Isoleucine tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (941 aa) |
| | DAMO_3119 | Putative 2-dehydropantoate 2-reductase (Ketopantoate reductase) (KPA reductase) (KPR); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (437 aa) |
| | DAMO_3069 | Serine palmitoyltransferase. (396 aa) |
| | DAMO_3068 | Phosphopantetheine attachment site. (82 aa) |
| | ilvD | Dihydroxy-acid dehydratase (DAD); Function of strongly homologous gene; enzyme; Belongs to the IlvD/Edd family. (557 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (285 aa) |
| | aspS | Aspartyl-tRNA synthetase / asparaginyl-tRNA synthetase (Aspartate-/asparagine-tRNA ligase) (AspRS); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (593 aa) |
| | hisS | Histidyl-tRNA synthetase (Histidine--tRNA ligase) (HisRS). (419 aa) |
| | proC | Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (271 aa) |
| | thrB | Homoserine kinase (HSK) (HK); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (295 aa) |
| | aroF-2 | 3-deoxy-7-phosphoheptulonate synthase; Phospho-2-dehydro-3-deoxyheptonate aldolase (Phospho-2-keto-3-deoxyheptonate aldolase) (DAHP synthetase) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase). (338 aa) |
| | serS | Seryl-tRNA synthetase (Serine--tRNA ligase); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (428 aa) |
| | DAMO_2929 | 2,3-diketo-5-methylthio-1-phosphopentane phosphatase. (222 aa) |
| | mtnD | Acireductone dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (177 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. (510 aa) |
| | trpS | Tryptophanyl-tRNA synthetase (Tryptophan--tRNA ligase) (TrpRS); Belongs to the class-I aminoacyl-tRNA synthetase family. (328 aa) |
