41 items (Wallemia mellicola) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I4YC37_WALMC	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (599 aa)
	I4Y5B8_WALMC	Pkinase-domain-containing protein. (578 aa)
	I4Y5D3_WALMC	PHD-type domain-containing protein. (492 aa)
	I4Y5E2_WALMC	Ubiquitin. (701 aa)
	I4Y5K3_WALMC	Noc2-domain-containing protein. (639 aa)
	I4Y5L5_WALMC	SIN1-domain-containing protein. (892 aa)
	I4Y5W1_WALMC	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (564 aa)
	I4Y6N3_WALMC	NuA4-domain-containing protein. (109 aa)
	Pbs2p	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	I4Y787_WALMC	Serine/threonine-protein kinase TOR. (2247 aa)
	I4Y7G3_WALMC	Uncharacterized protein. (798 aa)
	I4Y7K4_WALMC	Ubiquitin/40s ribosomal protein S27a fusion. (158 aa)
	I4Y8L7_WALMC	SAICAR synthase-like protein. (552 aa)
	I4Y9F5_WALMC	Uncharacterized protein. (465 aa)
	I4YAU5_WALMC	Chromatin modification-related protein. (315 aa)
	I4YG76_WALMC	HbrB-domain-containing protein. (520 aa)
	I4YG87_WALMC	FACT complex subunit SPT16. (1033 aa)
	Pbs2p-2	Kinase-like protein. (506 aa)
	I4YGX5_WALMC	NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30. (202 aa)
	I4YGZ3_WALMC	Uncharacterized protein. (307 aa)
	I4YHE2_WALMC	Pkinase-domain-containing protein. (578 aa)
	I4YHR0_WALMC	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily. (407 aa)
	I4YI50_WALMC	Kinase-like protein. (725 aa)
	I4YJP4_WALMC	SAE2 domain-containing protein. (90 aa)
	I4YJR9_WALMC	Kinase-like protein. (250 aa)
	I4YJY0_WALMC	Peptidyl-prolyl cis-trans isomerase. (168 aa)
	I4YCS6_WALMC	Uncharacterized protein. (891 aa)
	I4YCX6_WALMC	WD40 repeat-like protein. (311 aa)
	I4YD00_WALMC	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (248 aa)
	I4YD30_WALMC	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2030 aa)
	I4YDC8_WALMC	Uncharacterized protein. (1300 aa)
	MDM34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (597 aa)
	hal4	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily. (394 aa)
	I4YDJ6_WALMC	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (797 aa)
	I4YDK1_WALMC	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (324 aa)
	I4YE77_WALMC	ATP-dependent DNA helicase. (1115 aa)
	I4YEB6_WALMC	Chromatin modification-related protein. (383 aa)
	I4YG30_WALMC	DUF1767 domain-containing protein. (213 aa)
	I4YES0_WALMC	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily. (332 aa)
	I4YFP6_WALMC	Ribonuclease H-like protein. (337 aa)
	I4YB53_WALMC	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (808 aa)

Your Current Organism:

Wallemia mellicola

NCBI taxonomy Id: 671144
Other names: W. mellicola CBS 633.66, Wallemia mellicola CBS 633.66

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I4Y5B8_WALMC	I4Y7G3_WALMC	I4Y5B8	I4Y7G3	Pkinase-domain-containing protein.	Uncharacterized protein.	0.578
I4Y5B8_WALMC	I4YC37_WALMC	I4Y5B8	I4YC37	Pkinase-domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.498
I4Y5B8_WALMC	I4YD30_WALMC	I4Y5B8	I4YD30	Pkinase-domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.962
I4Y5B8_WALMC	I4YE77_WALMC	I4Y5B8	I4YE77	Pkinase-domain-containing protein.	ATP-dependent DNA helicase.	0.782
I4Y5B8_WALMC	I4YHE2_WALMC	I4Y5B8	I4YHE2	Pkinase-domain-containing protein.	Pkinase-domain-containing protein.	0.843
I4Y5B8_WALMC	hal4	I4Y5B8	I4YDE4	Pkinase-domain-containing protein.	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	0.842
I4Y5D3_WALMC	I4YB53_WALMC	I4Y5D3	I4YB53	PHD-type domain-containing protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.559
I4Y5E2_WALMC	I4Y787_WALMC	I4Y5E2	I4Y787	Ubiquitin.	Serine/threonine-protein kinase TOR.	0.868
I4Y5E2_WALMC	I4Y7K4_WALMC	I4Y5E2	I4Y7K4	Ubiquitin.	Ubiquitin/40s ribosomal protein S27a fusion.	0.991
I4Y5E2_WALMC	I4YC37_WALMC	I4Y5E2	I4YC37	Ubiquitin.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.618
I4Y5E2_WALMC	I4YGX5_WALMC	I4Y5E2	I4YGX5	Ubiquitin.	NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30.	0.915
I4Y5E2_WALMC	I4YJP4_WALMC	I4Y5E2	I4YJP4	Ubiquitin.	SAE2 domain-containing protein.	0.560
I4Y5L5_WALMC	I4Y787_WALMC	I4Y5L5	I4Y787	SIN1-domain-containing protein.	Serine/threonine-protein kinase TOR.	0.998
I4Y5L5_WALMC	I4YCX6_WALMC	I4Y5L5	I4YCX6	SIN1-domain-containing protein.	WD40 repeat-like protein.	0.999
I4Y5L5_WALMC	I4YDC8_WALMC	I4Y5L5	I4YDC8	SIN1-domain-containing protein.	Uncharacterized protein.	0.999
I4Y5L5_WALMC	I4YG76_WALMC	I4Y5L5	I4YG76	SIN1-domain-containing protein.	HbrB-domain-containing protein.	0.799
I4Y5W1_WALMC	I4YD00_WALMC	I4Y5W1	I4YD00	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.940
I4Y5W1_WALMC	I4YDK1_WALMC	I4Y5W1	I4YDK1	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.860
I4Y5W1_WALMC	I4YES0_WALMC	I4Y5W1	I4YES0	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	0.857
I4Y5W1_WALMC	I4YG87_WALMC	I4Y5W1	I4YG87	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	FACT complex subunit SPT16.	0.998