STRINGSTRING
mltF mltF metN metN rlpA rlpA lptE lptE AIL73212.1 AIL73212.1 AIL73123.1 AIL73123.1 AIL73121.1 AIL73121.1 AIL72947.1 AIL72947.1 AIL72889.1 AIL72889.1 AIL72879.1 AIL72879.1 AIL72827.1 AIL72827.1 AIL72801.1 AIL72801.1 AIL72756.1 AIL72756.1 AIL72709.1 AIL72709.1 AIL72702.1 AIL72702.1 AIL72564.1 AIL72564.1 AIL72412.1 AIL72412.1 AIL72407.1 AIL72407.1 AIL72367.1 AIL72367.1 AIL72364.1 AIL72364.1 AIL72333.1 AIL72333.1 AIL72276.1 AIL72276.1 AIL72237.1 AIL72237.1 AIL72210.1 AIL72210.1 AIL72192.1 AIL72192.1 AIL72142.1 AIL72142.1 AIL72129.1 AIL72129.1 AIL71857.1 AIL71857.1 pilQ pilQ AIL71778.1 AIL71778.1 AIL71777.1 AIL71777.1 AIL71771.1 AIL71771.1 AIL71746.1 AIL71746.1 AIL71613.1 AIL71613.1 mazG mazG AIL71598.1 AIL71598.1 AIL71546.1 AIL71546.1 AIL71545.1 AIL71545.1 AIL71543.1 AIL71543.1 AIL70616.1 AIL70616.1 AIL70596.1 AIL70596.1 AIL70465.1 AIL70465.1 AIL70449.1 AIL70449.1 AIL70380.1 AIL70380.1 AIL70377.1 AIL70377.1 lolB lolB AIL69403.1 AIL69403.1 AIL69344.1 AIL69344.1 AIL69328.1 AIL69328.1 ushA ushA AIL69970.1 AIL69970.1 flgH flgH AIL70009.1 AIL70009.1 AIL70013.1 AIL70013.1 AIL70076.1 AIL70076.1 AIL70079.1 AIL70079.1 AIL70147.1 AIL70147.1 nth nth AIL70219.1 AIL70219.1 AIL69303.1 AIL69303.1 AIL69295.1 AIL69295.1 btuB btuB AIL69248.1 AIL69248.1 fadL-2 fadL-2 fadL fadL truA truA AIL71157.1 AIL71157.1 AIL71136.1 AIL71136.1 AIL71116.1 AIL71116.1 AIL71113.1 AIL71113.1 pal pal AIL71057.1 AIL71057.1 AIL70866.1 AIL70866.1 AIL70836.1 AIL70836.1 AIL73316.1 AIL73316.1 AIL73461.1 AIL73461.1 AIL73580.1 AIL73580.1 AIL69419.1 AIL69419.1 lpxM lpxM bamE bamE AIL69856.1 AIL69856.1 bamB bamB bamD bamD lpoA lpoA tolC tolC AIL69553.1 AIL69553.1 lptD lptD AIL69518.1 AIL69518.1 lptA lptA AIL69494.1 AIL69494.1 AIL73249.1 AIL73249.1 AIL73260.1 AIL73260.1 AIL73283.1 AIL73283.1 AIL73343.1 AIL73343.1 ompU ompU mltA mltA ompK ompK nqrE nqrE glnD glnD bamA bamA bamC bamC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mltFTransglycosylase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (529 aa)
metNDL-methionine transporter ATP-binding subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (344 aa)
rlpARare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (264 aa)
lptERare lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (176 aa)
AIL73212.1Sulfate ABC transporter permease. (350 aa)
AIL73123.1Outer membrane protein. (325 aa)
AIL73121.1Outer membrane protein N, non-specific porin. (339 aa)
AIL72947.1Two-component response regulatory protein. (192 aa)
AIL72889.1Hypothetical protein. (178 aa)
AIL72879.1Hypothetical protein. (331 aa)
AIL72827.1Heme receptor. (712 aa)
AIL72801.1Long-chain fatty acid transport protein. (415 aa)
AIL72756.1Outer membrane protein. (191 aa)
AIL72709.1Surface protein. (1162 aa)
AIL72702.1Outer membrane protein, MtrB. (660 aa)
AIL72564.1Membrane protein. (183 aa)
AIL72412.1TonB-dependent heme receptor HutR. (711 aa)
AIL72407.1Outer membrane lipoprotein. (92 aa)
AIL72367.1Outer membrane protein V. (242 aa)
AIL72364.1Lipocalin; Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids. (171 aa)
AIL72333.1TonB-dependent receptor. (716 aa)
AIL72276.1Hypothetical protein. (371 aa)
AIL72237.1Ferrichrome-iron receptor. (721 aa)
AIL72210.1Maltoporin. (427 aa)
AIL72192.1Maltoporin. (426 aa)
AIL72142.1TonB-dependent receptor. (694 aa)
AIL72129.1Maltoporin. (419 aa)
AIL71857.1Hypothetical protein. (363 aa)
pilQType IV pilus (Tfp) assembly protein PilQ. (588 aa)
AIL71778.1Hypothetical protein. (403 aa)
AIL71777.1Secondary thiamine-phosphate synthase enzyme. (139 aa)
AIL71771.1Iron-hydroxamate ABC transporter substrate-binding protein. (220 aa)
AIL71746.1MSHA biogenesis protein MshL. (548 aa)
AIL71613.1Hypothetical protein. (426 aa)
mazGNucleoside triphosphate pyrophosphohydrolase. (269 aa)
AIL71598.1Membrane protein. (308 aa)
AIL71546.1Membrane carboxypeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (789 aa)
AIL71545.1Serine protease. (779 aa)
AIL71543.1Glycerate kinase; Belongs to the glycerate kinase type-1 family. (378 aa)
AIL70616.1NAD-specific glutamate dehydrogenase. (1613 aa)
AIL70596.1Polysaccharide export periplasmic protein. (699 aa)
AIL70465.1Outer membrane phospholipase A; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. (255 aa)
AIL70449.1Hypothetical protein. (182 aa)
AIL70380.1Membrane protein. (329 aa)
AIL70377.1Cytochrome c-type protein TorC; Belongs to the TorC/TorY family. (394 aa)
lolBOuter membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (202 aa)
AIL69403.1Sugar-phosphate nucleotide transferase. (353 aa)
AIL69344.1Hypothetical protein. (703 aa)
AIL69328.1Outer membrane receptor protein. (862 aa)
ushABifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic; Belongs to the 5'-nucleotidase family. (553 aa)
AIL69970.1Outer membrane protein. (364 aa)
flgHFlagellar basal body L-ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (259 aa)
AIL70009.1Nucleoside-diphosphate sugar epimerase. (304 aa)
AIL70013.1Hypothetical protein. (135 aa)
AIL70076.1Membrane-bound lytic murein transglycosylase B. (323 aa)
AIL70079.1Lipoprotein. (397 aa)
AIL70147.1D-Tyr-tRNAtyr deacylase. (1015 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa)
AIL70219.1Hypothetical protein. (130 aa)
AIL69303.1Type II secretory pathway, component EpsL; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (399 aa)
AIL69295.1Type II secretory pathway, component EpsD. (673 aa)
btuBOuter membrane cobalamin receptor protein; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. (613 aa)
AIL69248.1Membrane protein. (183 aa)
fadL-2Long-chain fatty acid transport protein. (438 aa)
fadLLong-chain fatty acid transport protein. (440 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (264 aa)
AIL71157.1Membrane protein. (196 aa)
AIL71136.1Membrane protein. (264 aa)
AIL71116.1Porin-like protein H. (316 aa)
AIL71113.1Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (741 aa)
palPeptidoglycan-associated lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (181 aa)
AIL71057.1Hypothetical protein. (185 aa)
AIL70866.1MltA-interacting protein MipA. (434 aa)
AIL70836.1Hypothetical protein. (387 aa)
AIL73316.1Long-chain fatty acid transport protein. (423 aa)
AIL73461.1Ferric aerobactin receptor. (718 aa)
AIL73580.1Outer membrane protein. (352 aa)
AIL69419.1Outer membrane capsular polysaccharide transport protein. (410 aa)
lpxMLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (330 aa)
bamESmall protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (135 aa)
AIL69856.1Oligoketide cyclase/lipid transport protein. (143 aa)
bamBOuter membrane protein assembly complex subunit YfgL; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (386 aa)
bamDLipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (241 aa)
lpoALipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). (603 aa)
tolCOuter membrane channel protein; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (441 aa)
AIL69553.1Hypothetical protein. (255 aa)
lptDOrganic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (776 aa)
AIL69518.1Polysialic acid capsule expression protein. (323 aa)
lptAABC transporter substrate-binding protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (164 aa)
AIL69494.1Outer membrane protein. (571 aa)
AIL73249.1Outer membrane protein. (193 aa)
AIL73260.1Pyridoxamine 5'-phosphate oxidase. (186 aa)
AIL73283.1Ferric vulnibactin outer membrane receptor. (685 aa)
AIL73343.1Porin. (242 aa)
ompUOuter membrane protein OmpU. (340 aa)
mltAMurein transglycosylase A. (367 aa)
ompKOuter membrane protein OmpK. (260 aa)
nqrENa(+)-translocating NADH-quinone reductase subunit E; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family. (198 aa)
glnDPII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (873 aa)
bamAOuter membrane protein assembly factor YaeT; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (804 aa)
bamCLipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (339 aa)
Your Current Organism:
Vibrio vulnificus
NCBI taxonomy Id: 672
Other names: ATCC 27562, BCRC 12905, Beneckea vulnifica, CAIM 610, CCRC 12905, CCRC:12905, CCUG 13448, CCUG 16394, CIP 75.4, CIP:75.04, DSM 10143, IFO 15645, JCM 3725, LMG 13545, LMG:13545, NBRC 15645, NCIMB 2046, NCTC 13647, V. vulnificus, strain 324
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