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hutG hutG hutH hutH AIL70943.1 AIL70943.1 nadA nadA aroA aroA AIL71204.1 AIL71204.1 asd-2 asd-2 aroC aroC dapE dapE dapA dapA dapD dapD AIL71508.1 AIL71508.1 AIL71552.1 AIL71552.1 AIL71566.1 AIL71566.1 AIL71591.1 AIL71591.1 AIL71625.1 AIL71625.1 sdhE sdhE AIL71757.1 AIL71757.1 aroB aroB aroK aroK ppc ppc metL metL AIL71810.1 AIL71810.1 astD astD frdD frdD aspA aspA aroQ aroQ aroE aroE ilvE ilvE AIL72331.1 AIL72331.1 AIL72676.1 AIL72676.1 AIL72891.1 AIL72891.1 AIL72935.1 AIL72935.1 AIL73101.1 AIL73101.1 AIL73273.1 AIL73273.1 AIL73279.1 AIL73279.1 AIL73335.1 AIL73335.1 AIL73558.1 AIL73558.1 AIL73559.1 AIL73559.1 lysA lysA dapF dapF AIL69264.1 AIL69264.1 lpxL lpxL AIL69392.1 AIL69392.1 AIL69402.1 AIL69402.1 lpxM lpxM mdh mdh AIL69539.1 AIL69539.1 AIL69607.1 AIL69607.1 AIL69608.1 AIL69608.1 dapB dapB gltB gltB gltD-2 gltD-2 AIL69677.1 AIL69677.1 thrA thrA AIL69735.1 AIL69735.1 tyrA tyrA AIL69743.1 AIL69743.1 AIL70090.1 AIL70090.1 asd asd AIL70285.1 AIL70285.1 sfcA sfcA astE astE AIL70602.1 AIL70602.1 AIL70616.1 AIL70616.1 hutI hutI hutU hutU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hutGFormimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (336 aa)
hutHHistidine ammonia-lyase; Belongs to the PAL/histidase family. (512 aa)
AIL70943.1Aromatic amino acid aminotransferase. (396 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (353 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa)
AIL71204.1Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (421 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (377 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
dapDTetrahydrodipicolinate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (343 aa)
AIL71508.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (276 aa)
AIL71552.17,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase. (161 aa)
AIL71566.1Quinolinate phosphoribosyltransferase; Belongs to the NadC/ModD family. (307 aa)
AIL71591.1Aspartate kinase; Belongs to the aspartokinase family. (381 aa)
AIL71625.1L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (548 aa)
sdhEHypothetical protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well. (86 aa)
AIL71757.1Aspartate kinase III; Belongs to the aspartokinase family. (490 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (363 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (877 aa)
metLBifunctional aspartate kinase II/homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. (803 aa)
AIL71810.1Malic enzyme. (425 aa)
astDSuccinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (485 aa)
frdDFumarate reductase subunit D; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (125 aa)
aspAAspartate ammonia-lyase. (483 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (162 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (277 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (312 aa)
AIL72331.1Lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (318 aa)
AIL72676.1MutT/nudix family protein. (151 aa)
AIL72891.1Aromatic amino acid aminotransferase. (395 aa)
AIL72935.1Arginase. (278 aa)
AIL73101.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa)
AIL73273.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa)
AIL73279.1Isochorismate-pyruvate lyase. (109 aa)
AIL73335.1Carboxypeptidase G2. (374 aa)
AIL73558.1Delta 1-pyrroline-5-carboxylate dehydrogenase. (235 aa)
AIL73559.1Bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1043 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (417 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (276 aa)
AIL69264.1SCP-2 sterol transfer family protein. (201 aa)
lpxLLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (312 aa)
AIL69392.1Phospho-2-dehydro-3-deoxyheptonate aldolase. (351 aa)
AIL69402.1Acetyltransferase. (212 aa)
lpxMLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (330 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (310 aa)
AIL69539.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (162 aa)
AIL69607.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa)
AIL69608.17,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase. (160 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (269 aa)
gltBGlutamate synthase subunit alpha. (1487 aa)
gltD-2Glutamate synthase subunit beta. (489 aa)
AIL69677.1Glutamate synthase. (1512 aa)
thrABifunctional aspartokinase I/homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. (819 aa)
AIL69735.1Phospho-2-dehydro-3-deoxyheptonate aldolase. (356 aa)
tyrABifunctional chorismate mutase/prephenate dehydrogenase. (375 aa)
AIL69743.1Prephenate dehydratase. (392 aa)
AIL70090.1Histidine ammonia-lyase. (512 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (371 aa)
AIL70285.14-amino-4-deoxychorismate lyase. (267 aa)
sfcAMalate dehydrogenase (oxaloacetate-decarboxylating); Belongs to the malic enzymes family. (562 aa)
astESuccinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (342 aa)
AIL70602.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa)
AIL70616.1NAD-specific glutamate dehydrogenase. (1613 aa)
hutIImidazolonepropionase; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (406 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (565 aa)
Your Current Organism:
Vibrio vulnificus
NCBI taxonomy Id: 672
Other names: ATCC 27562, BCRC 12905, Beneckea vulnifica, CAIM 610, CCRC 12905, CCRC:12905, CCUG 13448, CCUG 16394, CIP 75.4, CIP:75.04, DSM 10143, IFO 15645, JCM 3725, LMG 13545, LMG:13545, NBRC 15645, NCIMB 2046, NCTC 13647, V. vulnificus, strain 324
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