STRINGSTRING
adhE adhE SMD44_01788 SMD44_01788 frmA frmA SMD44_01758 SMD44_01758 SMD44_01631 SMD44_01631 SMD44_08321 SMD44_08321 SMD44_08323 SMD44_08323 mmsA mmsA SMD44_08363 SMD44_08363 SMD44_08486 SMD44_08486 SMD44_08528 SMD44_08528 SMD44_00395 SMD44_00395 gabD gabD eno eno aceE aceE SMD44_00220 SMD44_00220 SMD44_00217 SMD44_00217 prpD prpD prpB prpB SMD44_00214 SMD44_00214 SMD44_00762 SMD44_00762 SMD44_03272 SMD44_03272 SMD44_06601 SMD44_06601 SMD44_06637 SMD44_06637 SMD44_06638 SMD44_06638 SMD44_04298 SMD44_04298 SMD44_04332 SMD44_04332 SMD44_07883 SMD44_07883 sdhC sdhC sdhA sdhA sdhB sdhB trxA-2 trxA-2 SMD44_07744 SMD44_07744 poxB poxB korA korA korB korB acsA acsA sucD sucD sucC sucC mmsA-2 mmsA-2 SMD44_03036 SMD44_03036 SMD44_00622 SMD44_00622 aceE-2 aceE-2 SMD44_02556 SMD44_02556 frmA-2 frmA-2 SMD44_08166 SMD44_08166 GCA_000716675_03004 GCA_000716675_03004 SMD44_06874 SMD44_06874 SMD44_06829 SMD44_06829 poxB-2 poxB-2 acyP acyP gabT gabT ppdK ppdK puuE puuE rpe rpe frc-2 frc-2 SMD44_01280 SMD44_01280 SMD44_02089 SMD44_02089 tal tal zwf zwf SMD44_02092 SMD44_02092 pgl pgl pgi pgi tpiA tpiA pgk pgk SMD44_02101 SMD44_02101 mdh mdh SMD44_04405 SMD44_04405 SMD44_04456 SMD44_04456 SMD44_04457 SMD44_04457 SMD44_04458 SMD44_04458 SMD44_07628 SMD44_07628 aceE-3 aceE-3 SMD44_02388 SMD44_02388 SMD44_02387 SMD44_02387 gpmA gpmA SMD44_03699 SMD44_03699 frmA-3 frmA-3 SMD44_03750 SMD44_03750 SMD44_04844 SMD44_04844 SMD44_04839 SMD44_04839 SMD44_07426 SMD44_07426 SMD44_07425 SMD44_07425 gabD-2 gabD-2 sucC-2 sucC-2 sucD-2 sucD-2 SMD44_04634 SMD44_04634 eno-2 eno-2 SMD44_03569 SMD44_03569 pflA pflA SMD44_03565 SMD44_03565 SMD44_05846 SMD44_05846 sdhB-2 sdhB-2 sdhA-2 sdhA-2 SMD44_05668 SMD44_05668 SMD44_05981 SMD44_05981 ackA ackA pta pta pfkA pfkA pfkA-2 pfkA-2 yahK yahK SMD44_03590 SMD44_03590 SMD44_02195 SMD44_02195 sdhC-2 sdhC-2 sdhD sdhD sdhA-3 sdhA-3 sdhB-3 sdhB-3 SMD44_06467 SMD44_06467 SMD44_06466 SMD44_06466 pckG pckG pfkA-3 pfkA-3 ldhA ldhA SMD44_00094 SMD44_00094 fumC fumC SMD44_05634 SMD44_05634 glpX glpX ppgK ppgK rpiB rpiB SMD44_04476 SMD44_04476 SMD44_04475 SMD44_04475 SMD44_04474 SMD44_04474 SMD44_04662 SMD44_04662 SMD44_05857 SMD44_05857 prs prs ppc ppc SMD44_05507 SMD44_05507 SMD44_05508 SMD44_05508 deoC deoC SMD44_01160 SMD44_01160
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
adhEUnannotated protein; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (896 aa)
SMD44_01788Unannotated protein; Belongs to the aldehyde dehydrogenase family. (467 aa)
frmAUnannotated protein. (361 aa)
SMD44_01758Unannotated protein. (169 aa)
SMD44_01631Unannotated protein; Belongs to the monomeric-type IDH family. (739 aa)
SMD44_08321Unannotated protein. (335 aa)
SMD44_08323Unannotated protein. (324 aa)
mmsAUnannotated protein. (499 aa)
SMD44_08363Unannotated protein. (309 aa)
SMD44_08486Unannotated protein. (295 aa)
SMD44_08528Unannotated protein. (334 aa)
SMD44_00395Unannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa)
gabDUnannotated protein. (467 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
aceEUnannotated protein. (775 aa)
SMD44_00220Unannotated protein. (428 aa)
SMD44_00217Unannotated protein. (479 aa)
prpDUnannotated protein. (505 aa)
prpBUnannotated protein; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (301 aa)
SMD44_00214Unannotated protein; Belongs to the citrate synthase family. (381 aa)
SMD44_00762Unannotated protein. (849 aa)
SMD44_03272Unannotated protein. (476 aa)
SMD44_06601Unannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SMD44_06637Unannotated protein. (461 aa)
SMD44_06638Unannotated protein. (397 aa)
SMD44_04298Unannotated protein. (447 aa)
SMD44_04332Unannotated protein. (294 aa)
SMD44_07883Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (481 aa)
sdhCUnannotated protein. (235 aa)
sdhAUnannotated protein. (649 aa)
sdhBUnannotated protein. (248 aa)
trxA-2Unannotated protein. (127 aa)
SMD44_07744Unannotated protein. (480 aa)
poxBUnannotated protein; Belongs to the TPP enzyme family. (607 aa)
korAUnannotated protein. (644 aa)
korBUnannotated protein. (360 aa)
acsAUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (379 aa)
mmsA-2Unannotated protein. (509 aa)
SMD44_03036Unannotated protein; Belongs to the citrate synthase family. (432 aa)
SMD44_00622Unannotated protein. (381 aa)
aceE-2Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
SMD44_02556Unannotated protein; Belongs to the aldehyde dehydrogenase family. (492 aa)
frmA-2Unannotated protein. (360 aa)
SMD44_08166Unannotated protein; Belongs to the aldehyde dehydrogenase family. (518 aa)
GCA_000716675_03004Unannotated protein. (484 aa)
SMD44_06874Unannotated protein; Belongs to the malate synthase family. (540 aa)
SMD44_06829Unannotated protein. (568 aa)
poxB-2Unannotated protein; Belongs to the TPP enzyme family. (594 aa)
acyPUnannotated protein. (93 aa)
gabTUnannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
ppdKUnannotated protein; Belongs to the PEP-utilizing enzyme family. (911 aa)
puuEUnannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
rpeUnannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
frc-2Unannotated protein; Belongs to the CoA-transferase III family. (398 aa)
SMD44_01280Unannotated protein. (300 aa)
SMD44_02089Unannotated protein; Belongs to the transketolase family. (702 aa)
talUnannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa)
zwfUnannotated protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (507 aa)
SMD44_02092Unannotated protein. (354 aa)
pglUnannotated protein; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (266 aa)
pgiUnannotated protein; Belongs to the GPI family. (550 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (403 aa)
SMD44_02101Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
SMD44_04405Unannotated protein. (491 aa)
SMD44_04456Unannotated protein. (380 aa)
SMD44_04457Unannotated protein. (334 aa)
SMD44_04458Unannotated protein. (557 aa)
SMD44_07628Unannotated protein; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (479 aa)
aceE-3Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (897 aa)
SMD44_02388Unannotated protein. (595 aa)
SMD44_02387Unannotated protein. (462 aa)
gpmAUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa)
SMD44_03699Unannotated protein. (741 aa)
frmA-3Unannotated protein. (349 aa)
SMD44_03750Unannotated protein; Belongs to the citrate synthase family. (366 aa)
SMD44_04844Unannotated protein; Belongs to the group II decarboxylase family. (470 aa)
SMD44_04839Unannotated protein; Belongs to the aldehyde dehydrogenase family. (485 aa)
SMD44_07426Unannotated protein. (233 aa)
SMD44_07425Unannotated protein. (298 aa)
gabD-2Unannotated protein; Belongs to the aldehyde dehydrogenase family. (538 aa)
sucC-2Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
sucD-2Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
SMD44_04634Unannotated protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
eno-2Unannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
SMD44_03569Unannotated protein. (751 aa)
pflAUnannotated protein; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (285 aa)
SMD44_03565Unannotated protein. (72 aa)
SMD44_05846Unannotated protein. (404 aa)
sdhB-2Unannotated protein. (278 aa)
sdhA-2Unannotated protein. (647 aa)
SMD44_05668Unannotated protein. (277 aa)
SMD44_05981Unannotated protein; Belongs to the pyruvate kinase family. (476 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa)
ptaUnannotated protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (701 aa)
pfkAUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
pfkA-2Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
yahKUnannotated protein. (350 aa)
SMD44_03590Unannotated protein; Belongs to the aldehyde dehydrogenase family. (516 aa)
SMD44_02195Unannotated protein; Belongs to the pyruvate kinase family. (478 aa)
sdhC-2Unannotated protein. (126 aa)
sdhDUnannotated protein. (164 aa)
sdhA-3Unannotated protein. (584 aa)
sdhB-3Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (253 aa)
SMD44_06467Unannotated protein; Belongs to the citrate synthase family. (395 aa)
SMD44_06466Unannotated protein. (448 aa)
pckGUnannotated protein; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (616 aa)
pfkA-3Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
ldhAUnannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
SMD44_00094Unannotated protein. (388 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (477 aa)
SMD44_05634Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (555 aa)
glpXUnannotated protein. (344 aa)
ppgKUnannotated protein. (250 aa)
rpiBUnannotated protein. (162 aa)
SMD44_04476Unannotated protein. (491 aa)
SMD44_04475Unannotated protein. (326 aa)
SMD44_04474Unannotated protein. (412 aa)
SMD44_04662Unannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
SMD44_05857Unannotated protein. (1270 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (328 aa)
ppcUnannotated protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (922 aa)
SMD44_05507Unannotated protein. (299 aa)
SMD44_05508Unannotated protein. (486 aa)
deoCUnannotated protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (288 aa)
SMD44_01160Unannotated protein. (467 aa)
Your Current Organism:
Streptomyces alboflavus
NCBI taxonomy Id: 67267
Other names: ATCC 12626, ATCC 23874, Actinomyces alboflavus, BCRC 13664, CBS 613.68, CCRC 13664, CCRC:13664, CIP 104427, DSM 40045, IFO 13196, IMET 42936, ISP 5045, JCM 4615, KCTC 9674, NBRC 13196, NRRL B-2373, NRRL-ISP 5045, S. alboflavus, Streptomyces albiflavus, VKM Ac-972
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