STRINGSTRING
GCA_000716675_00200 GCA_000716675_00200 SMD44_01867 SMD44_01867 manB-2 manB-2 SMD44_04361 SMD44_04361 ppc ppc prs prs glmU glmU GCA_000716675_07948 GCA_000716675_07948 SMD44_05857 SMD44_05857 purA purA cofD cofD glnE glnE upp upp GCA_000716675_07688 GCA_000716675_07688 SMD44_04474 SMD44_04474 GCA_000716675_07539 GCA_000716675_07539 kdpB-2 kdpB-2 SMD44_06719 SMD44_06719 panB panB pnp pnp SMD44_05616 SMD44_05616 ilvD-2 ilvD-2 kdpB kdpB bioD bioD thiE thiE GCA_000716675_06866 GCA_000716675_06866 SMD44_06123 SMD44_06123 ilvC ilvC leuB leuB purL purL purF purF SMD44_02195 SMD44_02195 obg obg murE murE hisI hisI metK-2 metK-2 ackA ackA SMD44_05981 SMD44_05981 SMD44_06024 SMD44_06024 galK galK eno-2 eno-2 pyrE pyrE sucC-2 sucC-2 acpS acpS glmM glmM SMD44_07425 SMD44_07425 SMD44_07426 SMD44_07426 SMD44_07570 SMD44_07570 ppa ppa ilvD ilvD dgt-2 dgt-2 vapC-2 vapC-2 SMD44_02694 SMD44_02694 serB-2 serB-2 SMD44_05960 SMD44_05960 mshA mshA trpD-2 trpD-2 aceE-3 aceE-3 glgA glgA SMD44_07674 SMD44_07674 lysS lysS SMD44_04456 SMD44_04456 pepM pepM SMD44_04366 SMD44_04366 dxs-2 dxs-2 nfi nfi SMD44_02089 SMD44_02089 dapD dapD SMD44_01296 SMD44_01296 SMD44_01567 SMD44_01567 ruvC ruvC aroK aroK metK metK ribBA ribBA hisG hisG SMD44_01445 SMD44_01445 SMD44_07051 SMD44_07051 uppS uppS thiL thiL poxB-2 poxB-2 gcl gcl xylA xylA ttuC ttuC aceE-2 aceE-2 dgt dgt trpD trpD SMD44_03063 SMD44_03063 iolD iolD SMD44_07157 SMD44_07157 sucC sucC dgoD-2 dgoD-2 hppA hppA SMD44_04691 SMD44_04691 korB korB korA korA rpoC rpoC poxB poxB GCA_000716675_01812 GCA_000716675_01812 SMD44_07957 SMD44_07957 parA parA vapC vapC dxs dxs SMD44_00823 SMD44_00823 aceE aceE eno eno dgoD dgoD SMD44_08321 SMD44_08321 pheT pheT pheS pheS pafA-2 pafA-2 SMD44_01832 SMD44_01832
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GCA_000716675_00200Unannotated protein. (245 aa)
SMD44_01867Unannotated protein. (421 aa)
manB-2Unannotated protein. (555 aa)
SMD44_04361Unannotated protein. (385 aa)
ppcUnannotated protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (922 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (328 aa)
glmUUnannotated protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (469 aa)
GCA_000716675_07948Unannotated protein. (154 aa)
SMD44_05857Unannotated protein. (1270 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
cofDUnannotated protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (318 aa)
glnEUnannotated protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) [...] (997 aa)
uppUnannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
GCA_000716675_07688Unannotated protein. (141 aa)
SMD44_04474Unannotated protein. (412 aa)
GCA_000716675_07539Unannotated protein. (176 aa)
kdpB-2Unannotated protein; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (707 aa)
SMD44_06719Unannotated protein. (245 aa)
panBUnannotated protein; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (293 aa)
pnpUnannotated protein; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (741 aa)
SMD44_05616Unannotated protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (259 aa)
ilvD-2Unannotated protein; Belongs to the IlvD/Edd family. (603 aa)
kdpBUnannotated protein; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (720 aa)
bioDUnannotated protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (237 aa)
thiEUnannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (223 aa)
GCA_000716675_06866Unannotated protein. (201 aa)
SMD44_06123Unannotated protein. (617 aa)
ilvCUnannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
leuBUnannotated protein. (346 aa)
purLUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (749 aa)
purFUnannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (508 aa)
SMD44_02195Unannotated protein; Belongs to the pyruvate kinase family. (478 aa)
obgUnannotated protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (482 aa)
murEUnannotated protein; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (570 aa)
hisIUnannotated protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (127 aa)
metK-2Unannotated protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (387 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa)
SMD44_05981Unannotated protein; Belongs to the pyruvate kinase family. (476 aa)
SMD44_06024Unannotated protein. (500 aa)
galKUnannotated protein; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (387 aa)
eno-2Unannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
pyrEUnannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (183 aa)
sucC-2Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
acpSUnannotated protein; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (122 aa)
glmMUnannotated protein; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (452 aa)
SMD44_07425Unannotated protein. (298 aa)
SMD44_07426Unannotated protein. (233 aa)
SMD44_07570Unannotated protein; Belongs to the P-Pant transferase superfamily. (275 aa)
ppaUnannotated protein; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (163 aa)
ilvDUnannotated protein; Belongs to the IlvD/Edd family. (617 aa)
dgt-2Unannotated protein; Belongs to the dGTPase family. Type 2 subfamily. (440 aa)
vapC-2Unannotated protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (135 aa)
SMD44_02694Unannotated protein. (329 aa)
serB-2Unannotated protein. (418 aa)
SMD44_05960Unannotated protein; Belongs to the ComB family. (252 aa)
mshAUnannotated protein; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (465 aa)
trpD-2Unannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa)
aceE-3Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (897 aa)
glgAUnannotated protein. (389 aa)
SMD44_07674Unannotated protein; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (484 aa)
lysSUnannotated protein; Belongs to the class-II aminoacyl-tRNA synthetase family. (1098 aa)
SMD44_04456Unannotated protein. (380 aa)
pepMUnannotated protein. (285 aa)
SMD44_04366Unannotated protein. (425 aa)
dxs-2Unannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (666 aa)
nfiUnannotated protein; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (236 aa)
SMD44_02089Unannotated protein; Belongs to the transketolase family. (702 aa)
dapDUnannotated protein; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (332 aa)
SMD44_01296Unannotated protein; Belongs to the P-Pant transferase superfamily. (222 aa)
SMD44_01567Unannotated protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (224 aa)
ruvCUnannotated protein; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (215 aa)
aroKUnannotated protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (179 aa)
metKUnannotated protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
ribBAUnannotated protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (443 aa)
hisGUnannotated protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa)
SMD44_01445Unannotated protein. (229 aa)
SMD44_07051Unannotated protein. (367 aa)
uppSUnannotated protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (275 aa)
thiLUnannotated protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa)
poxB-2Unannotated protein; Belongs to the TPP enzyme family. (594 aa)
gclUnannotated protein; Belongs to the TPP enzyme family. (595 aa)
xylAUnannotated protein. (388 aa)
ttuCUnannotated protein. (355 aa)
aceE-2Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
dgtUnannotated protein; Belongs to the dGTPase family. Type 2 subfamily. (441 aa)
trpDUnannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa)
SMD44_03063Unannotated protein; Belongs to the TPP enzyme family. (561 aa)
iolDUnannotated protein; Belongs to the TPP enzyme family. (635 aa)
SMD44_07157Unannotated protein. (563 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (379 aa)
dgoD-2Unannotated protein. (381 aa)
hppAUnannotated protein; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. (800 aa)
SMD44_04691Unannotated protein. (598 aa)
korBUnannotated protein. (360 aa)
korAUnannotated protein. (644 aa)
rpoCUnannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1303 aa)
poxBUnannotated protein; Belongs to the TPP enzyme family. (607 aa)
GCA_000716675_01812Unannotated protein. (87 aa)
SMD44_07957Unannotated protein. (530 aa)
parAUnannotated protein. (342 aa)
vapCUnannotated protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (147 aa)
dxsUnannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (659 aa)
SMD44_00823Unannotated protein. (156 aa)
aceEUnannotated protein. (775 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
dgoDUnannotated protein; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (384 aa)
SMD44_08321Unannotated protein. (335 aa)
pheTUnannotated protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (863 aa)
pheSUnannotated protein; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (383 aa)
pafA-2Unannotated protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. (453 aa)
SMD44_01832Unannotated protein. (512 aa)
Your Current Organism:
Streptomyces alboflavus
NCBI taxonomy Id: 67267
Other names: ATCC 12626, ATCC 23874, Actinomyces alboflavus, BCRC 13664, CBS 613.68, CCRC 13664, CCRC:13664, CIP 104427, DSM 40045, IFO 13196, IMET 42936, ISP 5045, JCM 4615, KCTC 9674, NBRC 13196, NRRL B-2373, NRRL-ISP 5045, S. alboflavus, Streptomyces albiflavus, VKM Ac-972
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